التفاصيل البيبلوغرافية
| العنوان: |
Characteristics and Outcomes Among Recipients of Dcd Versus Dbd Heart Transplantation - The Vanderbilt Experience. |
| المؤلفون: |
Siddiqi, H.1 (AUTHOR), DeBose-Scarlett, A.1 (AUTHOR), Trahanas, J.1 (AUTHOR), Pasrija, C.1 (AUTHOR), Amancherla, K.1 (AUTHOR), Brinkley, D.1 (AUTHOR), Lindenfeld, J.1 (AUTHOR), Menachem, J.1 (AUTHOR), Ooi, H.1 (AUTHOR), Pedrotty, D.1 (AUTHOR), Punnoose, L.1 (AUTHOR), Rali, A.1 (AUTHOR), Sacks, S.1 (AUTHOR), Wigger, M.1 (AUTHOR), Zalawadiya, S.1 (AUTHOR), McMaster, W.1 (AUTHOR), Shah, A.1 (AUTHOR), Schlendorf, K.1 (AUTHOR) |
| المصدر: |
Journal of Heart & Lung Transplantation. 2023 Supplement, Vol. 42, pS145-S146. 2p. |
| مصطلحات موضوعية: |
*HEART transplantation, *HOMOGRAFTS, *KIDNEY transplantation, *HEART transplant recipients, *ORGAN donation, *HEPATITIS C, *ELECTRONIC health records |
| الشركة/الكيان: |
VANDERBILT University. Medical Center |
| مستخلص: |
There is growing interest in organ donation after circulatory death (DCD) to expand the pool of cardiac allografts for heart transplantation. Early reports of outcomes in recipients of DCD hearts have been encouraging and comparable to those in recipients of donation after brain death (DBD), but data are limited. We present the largest single-center report of characteristics and outcomes among recipients of DCD versus DBD heart transplantation. We retrospectively reviewed all adults undergoing heart-only transplantation at Vanderbilt University Medical Center between 1/1/2020 and 6/30/2022. Baseline recipient and donor characteristics, surgical details and outcomes including mortality and coronary allograft vasculopathy (CAV) were abstracted from the electronic health record. Regression and survival analyses were used to study the independent effect of DCD versus DBD donors on outcomes, adjusting for recipient characteristics (age and listing status at transplant, sex, diabetes) and donor factors (age, hypertension, hepatitis C, tobacco history). During this period, 187 DBD and 90 DCD heart-only transplants were performed. DCD donors were significantly younger, more likely to be male and white, and less likely to have hypertension, hepatitis C and tobacco history. DCD recipients were more likely to be male and have lower UNOS status at transplant. There was no significant difference in risk of adjusted 30-day survival, and for those with one year follow up, in 1-year survival (Figure) and CAV at one year (adjusted OR 0.91, 95% confidence interval 0.17-4.55, p=0.91) between DCD and DBD recipients. One-year follow-up data will be available for 80% of patients by ISHLT 2023. In this large and contemporary cohort of heart transplant recipients, there were no differences in 30-day or 1-year mortality, or CAV at one year based on DCD versus DBD donors. Our results support widespread adoption of DCD heart transplantation to expand the donor pool. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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