التفاصيل البيبلوغرافية
| العنوان: |
Increasing SARS-CoV-2 seroprevalence among UK pediatric patients on dialysis and kidney transplantation between January 2020 and August 2021. |
| المؤلفون: |
Bamber, Holly N., Kim, Jon Jin, Reynolds, Ben C., Afzaal, Javairiya, Lunn, Andrew J., Tighe, Patrick J., Irving, William L., Tarr, Alexander W. |
| المصدر: |
Pediatric Nephrology; Nov2023, Vol. 38 Issue 11, p3745-3755, 11p, 1 Diagram, 1 Chart, 3 Graphs |
| مصطلحات موضوعية: |
RESEARCH, SEROPREVALENCE, THERAPEUTICS, COVID-19, IMMUNOGLOBULINS, CROSS-sectional method, KIDNEY transplantation, PATIENTS, PERITONEAL dialysis, RENAL replacement therapy, RESEARCH funding, HEMODIALYSIS, STAY-at-home orders, SOCIAL distancing, TRANSPLANTATION of organs, tissues, etc., CHILDREN |
| مصطلحات جغرافية: |
UNITED Kingdom |
| مستخلص: |
Background : Coronavirus disease 2019 (COVID-19) was officially declared a pandemic by the World Health Organisation (WHO) on 11 March 2020, as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly across the world. We investigated the seroprevalence of anti-SARS-CoV-2 antibodies in pediatric patients on dialysis or kidney transplantation in the UK. Methods: Excess sera samples were obtained prospectively during outpatient visits or haemodialysis sessions and analysed using a custom immunoassay calibrated with population age-matched healthy controls. Two large pediatric centres contributed samples. Results: In total, 520 sera from 145 patients (16 peritoneal dialysis, 16 haemodialysis, 113 transplantation) were analysed cross-sectionally from January 2020 until August 2021. No anti-SARS-CoV-2 antibody positive samples were detected in 2020 when lockdown and enhanced social distancing measures were enacted. Thereafter, the proportion of positive samples increased from 5% (January 2021) to 32% (August 2021) following the emergence of the Alpha variant. Taking all patients, 32/145 (22%) were seropositive, including 8/32 (25%) with prior laboratory-confirmed SARS-CoV-2 infection and 12/32 (38%) post-vaccination (one of whom was also infected after vaccination). The remaining 13 (41%) seropositive patients had no known stimulus, representing subclinical cases. Antibody binding signals were comparable across patient ages and dialysis versus transplantation and highest against full-length spike protein versus spike subunit-1 and nucleocapsid protein. Conclusions: Anti-SARS-CoV-2 seroprevalence was low in 2020 and increased in early 2021. Serological surveillance complements nucleic acid detection and antigen testing to build a greater picture of the epidemiology of COVID-19 and is therefore important to guide public health responses. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
