دورية أكاديمية
Conserved angio-immune subtypes of the tumor microenvironment predict response to immune checkpoint blockade therapy
| العنوان: | Conserved angio-immune subtypes of the tumor microenvironment predict response to immune checkpoint blockade therapy |
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| المؤلفون: | Subramanian, Madhav, Kabir, Ashraf Ul, Barisas, Derek, Krchma, Karen, Choi, Kyunghee |
| المصدر: | 2020-Current year OA Pubs |
| بيانات النشر: | Digital Commons@Becker |
| سنة النشر: | 2023 |
| المجموعة: | Washington University School of Medicine: Digital Commons@Becker |
| مصطلحات موضوعية: | Humans, Immune Checkpoint Inhibitors, Tumor Microenvironment, Carcinoma, Renal Cell, Transcriptome, Kidney Neoplasms, ICTS (Institute of Clinical and Translational Sciences), Medicine and Health Sciences |
| الوصف: | Immune checkpoint blockade (ICB) therapy has revolutionized cancer treatment. However, only a fraction of patients respond to ICB therapy. Accurate prediction of patients to likely respond to ICB would maximize the efficacy of ICB therapy. The tumor microenvironment (TME) dictates tumor progression and therapy outcome. Here, we classify the TME by analyzing the transcriptome from 11,069 cancer patients based on angiogenesis and T cell activity. We find three distinct angio-immune TME subtypes conserved across 30 non-hematological cancers. There is a clear inverse relationship between angiogenesis and anti-tumor immunity in TME. Remarkably, patients displaying TME with low angiogenesis with strong anti-tumor immunity show the most significant responses to ICB therapy in four cancer types. Re-evaluation of the renal cell carcinoma clinical trials provides compelling evidence that the baseline angio-immune state is robustly predictive of ICB responses. This study offers a rationale for incorporating baseline angio-immune scores for future ICB treatment strategies. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://digitalcommons.wustl.edu/oa_4/1686Test; https://digitalcommons.wustl.edu/context/oa_4/article/2689/viewcontent/1_s2.0_S266637912200475X_main.pdfTest |
| DOI: | 10.1016/j.xcrm.2022.100896 |
| الإتاحة: | https://doi.org/10.1016/j.xcrm.2022.100896Test https://digitalcommons.wustl.edu/oa_4/1686Test https://digitalcommons.wustl.edu/context/oa_4/article/2689/viewcontent/1_s2.0_S266637912200475X_main.pdfTest |
| رقم الانضمام: | edsbas.5F8E79AD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.xcrm.2022.100896 |
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