دورية أكاديمية
TOLLIP Protein Expression Predicts Unfavorable Outcome in Renal Cell Carcinoma
| العنوان: | TOLLIP Protein Expression Predicts Unfavorable Outcome in Renal Cell Carcinoma |
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| المؤلفون: | Adam Kowalewski, Damian Jaworski, Jędrzej Borowczak, Mateusz Maniewski, Krzysztof Szczerbowski, Paulina Antosik, Justyna Durślewicz, Marta Smolińska, Joanna Ligmanowska, Dariusz Grzanka, Łukasz Szylberg |
| المصدر: | International Journal of Molecular Sciences, Vol 23, Iss 23, p 14702 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | TOLLIP, renal cell carcinoma, kidney, cancer, expression, prognosis, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Resistance to systemic therapy is one of the hallmarks of renal cell carcinoma (RCC). Recently, TOLLIP has emerged as a possible driver of autophagy and chemoresistance. We explored the relationship between primary and metastatic RCC tumor characteristics, patient survival, and TOLLIP expression. The tissue microarrays cohort contained 95 cores of the primary tumor, matched metastases, and matched adjacent tissues derived from 32 RCC patients. TOLLIP expression in tumor samples was evaluated using the H-score. All examined samples showed cytoplasmic TOLLIP expression, with a median value of 100 in primary tumors, 107.5 in metastases, and 220 in the control group. The expression was significantly higher in the normal adjacent tissues compared to primary or metastatic RCC (p < 0.05). We found a positive correlation between expressions of TOLLIP in the primary tumor and its metastases (p < 0.05; k = 0.48). TOLLIP expression significantly correlates with a lower overall survival rate (p = 0.047). TOLLIP functions as a ubiquitin-LC3 adaptor in the intracellular pathway associated with autophagy. Relative TOLLIP overexpression may augment autophagy-related signaling, limiting susceptibility to therapy. The blockade of TOLLIP physiological function seems to be a promising approach to overcoming resistance to systemic therapy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/23/23/14702Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms232314702 |
| الوصول الحر: | https://doaj.org/article/52b14c6d38ae45989d1caf4438116b36Test |
| رقم الانضمام: | edsdoj.52b14c6d38ae45989d1caf4438116b36 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms232314702 |