التفاصيل البيبلوغرافية
| العنوان: |
KIBRA connects Hippo signaling and cancer. |
| المؤلفون: |
Swaroop B, Srikanth Swamy1,2 (AUTHOR), Kanumuri, Rahul1,2 (AUTHOR), Ezhil, Inemai2 (AUTHOR), Naidu Sampangi, Jagadeesh Kumar1 (AUTHOR), Kremerskothen, Joachim3 (AUTHOR), Rayala, Suresh Kumar1,2 (AUTHOR) rayala@iitm.ac.in, Venkatraman, Ganesh1 (AUTHOR) ganeshv@sriramachandra.edu.in |
| المصدر: |
Experimental Cell Research. Jun2021, Vol. 403 Issue 2, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*HOMEOSTASIS, *ONCOGENES, *CELL communication |
| مستخلص: |
The Hippo signaling pathway is a tumor suppressor pathway that plays an important role in tissue homeostasis and organ size control. KIBRA is one of the many upstream regulators of the Hippo pathway. It functions as a tumor suppressor by positively regulating the core Hippo kinase cascade. However, there are accumulating shreds of evidence showing that KIBRA has an oncogenic function, which we speculate may arise from its functions away from the Hippo pathway. In this review, we have attempted to provide an overview of the Hippo signaling with a special emphasis on evidence showing the paradoxical role of KIBRA in cancer. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
