التفاصيل البيبلوغرافية
العنوان:
Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events A GENIUS-CHD Study of Individual Participant Data
المؤلفون:
Patel, Riyaz S. , Schmidt, Amand F. , Tragante, Vinicius , McCubrey, Raymond O. , Holmes, Michael, V , Howe, Laurence J. , Direk, Kenan , Åkerblom, Axel , Leander, Karin , Virani, Salim S. , Kaminski, Karol A. , Muehlschlegel, Jochen D. , Dube, Marie-Pierre , Allayee, Hooman , Almgren, Peter , Alver, Maris , Baranova, Ekaterina, V , Behlouli, Hassan , Boeckx, Bram , Braund, Peter S. , Breitling, Lutz P. , Delgado, Graciela , Duarte, Nubia E. , Dufresne, Line , Eriksson, Niclas , Foco, Luisa , Gijsberts, Crystel M. , Gong, Yan , Hartiala, Jaana , Heydarpour, Mahyar , Hubacek, Jaroslav A. , Kleber, Marcus , Kofink, Daniel , Kuukasjarvi, Pekka , Lee, Vei-Vei , Leiherer, Andreas , Lenzini, Petra A. , Levin, Daniel , Lyytikainen, Leo-Pekka , Martinelli, Nicola , Mons, Ute , Nelson, Christopher P. , Nikus, Kjell , Pilbrow, Anna P. , Ploski, Rafal , Sun, Yan, V , Tanck, Michael W. T. , Tang, W. H. Wilson , Trompet, Stella , van der Laan, Sander W. , van Setten, Jessica , Vilmundarson, Ragnar O. , Anselmi, Chiara Viviani , Vlachopoulou, Efthymia , Boerwinkle, Eric , Briguori, Carlo , Carlquist, John F. , Carruthers, Kathryn F. , Casu, Gavino , Deanfield, John , Deloukas, Panos , Dudbridge, Frank , Fitzpatrick, Natalie , Gigante, Bruna , James, Stefan , Lokki, Marja-Liisa , Lotufo, Paulo A. , Marziliano, Nicola , Mordi, Ify R. , Muhlestein, Joseph B. , Cheh, Chris Newton , Pitha, Jan , Saely, Christoph H. , Samman-Tahhan, Ayman , Sandesara, Pratik B. , Teren, Andrej , Timmis, Adam , Van de Werf, Frans , Wauters, Els , Wilde, Arthur A. M. , Ford, Ian , Stott, David J. , Algra, Ale , Andreassi, Maria G. , Ardissino, Diego , Arsenault, Benoit J. , Ballantyne, Christie M. , Bergmeijer, Thomas O. , Bezzina, Connie R. , Body, Simon C. , Bogaty, Peter , de Borst, Gert J. , Brenner, Hermann , Burkhardt, Ralph , Carpeggiani, Clara , Condorelli, Gianluigi , Cooper-DeHoff, Rhonda M. , Cresci, Sharon , de Faire, Ulf , Doughty, Robert N. , Drexel, Heinz , Engert, James C. , Fox, Keith A. A. , Girelli, Domenico , Hagström, Emil , Hazen, Stanley L. , Held, Claes , Hemingway, Harry , Hoefer, Imo E. , Hovingh, G. Kees , Johnson, Julie A. , De Jong, Pim A. , Jukema, J. Wouter , Kaczor, Marcin P. , Kahonen, Mika , Kettner, Jiri , Kiliszek, Marek , Klungel, Olaf H. , Lagerqvist, Bo , Lambrechts, Diether , Laurikka, Jari O. , Lehtimaki, Terho , Lindholm, Daniel , Mahmoodi, Bakhtawar K. , Maitland-van der Zee, Anke H. , McPherson, Ruth , Melander, Olle , Metspalu, Andres , Pepinski, Witold , Olivieri, Oliviero , Opolski, Grzegorz , Palmer, Colin N. , Pasterkamp, Gerard , Pepine, Carl J. , Pereira, Alexandre C. , Note, Louise , Quyyumi, Arshed A. , Richards, A. Mark , Sanak, Marek , Scholz, Markus , Siegbahn, Agneta , Sinisalo, Juha , Smith, J. Gustav , Spertus, John A. , Stewart, Alexandre F. R. , Szczeklik, Wojciech , Szpakowicz, Anna , ten Berg, Jurrien M. , Thanassoulis, George , Thieiy, Joachim , van der Graaf, Yolanda , Visseren, Frank L. J. , Waltenberger, Johannes , Van der Harst, Pim , Tardif, Jean-Claude , Sattar, Naveed , Lang, Chim C. , Pare, Guillaume , Brophy, James M. , Anderson, Jeffrey L. , Maerz, Winfried , Wallentin, Lars , Cameron, Vicky A. , Horne, Benjamin D. , Samani, Nilesh J. , Hingorani, Aroon D. , Asselbergs, Folkert W.
بيانات النشر:
LIPPINCOTT WILLIAMS & WILKINS, 2019.
سنة النشر:
2019
مصطلحات موضوعية:
Genetics & Heredity , RISK , Kardiologi , Science & Technology , Cardiac & Cardiovascular Systems , VARIANTS , RECURRENT MYOCARDIAL-INFARCTION , myocardial infarction , risk factor , BIAS , Cardiovascular System & Cardiology , LOCUS , Cardiac and Cardiovascular Systems , cardiovascular diseases , chromosome , genetic , variation , Medical Genetics , Life Sciences & Biomedicine , secondary prevention , Medicinsk genetik
الوصف:
BACKGROUND: Genetic variation at chromosome 9p21 is a recognized risk factor for coronary heart disease (CHD). However, its effect on disease progression and subsequent events is unclear, raising questions about its value for stratification of residual risk. METHODS: A variant at chromosome 9p21 (rs1333049) was tested for association with subsequent events during follow-up in 103 357 Europeans with established CHD at baseline from the GENIUS-CHD (Genetics of Subsequent Coronary Heart Disease) Consortium (73.1% male, mean age 62.9 years). The primary outcome, subsequent CHD death or myocardial infarction (CHD death/myocardial infarction), occurred in 13 040 of the 93 115 participants with available outcome data. Effect estimates were compared with case/control risk obtained from the CARDIoGRAMplusC4D consortium (Coronary Artery Disease Genome-wide Replication and Meta-analysis [CARDIoGRAM] plus The Coronary Artery Disease [C4D] Genetics) including 47 222 CHD cases and 122 264 controls free of CHD. RESULTS: Meta-analyses revealed no significant association between chromosome 9p21 and the primary outcome of CHD death/myocardial infarction among those with established CHD at baseline (GENIUS-CHD odds ratio, 1.02; 95% CI, 0.99-1.05). This contrasted with a strong association in CARDIoGRAMPlusC4D odds ratio 1.20; 95% CI, 1.18-1.22; P for interaction
وصف الملف:
Print-Electronic; application/pdf
اللغة:
English
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e1fc573845610c20596549322f6f614cTest https://lirias.kuleuven.be/handle/123456789/654752Test
حقوق:
OPEN
رقم الانضمام:
edsair.dedup.wf.001..e1fc573845610c20596549322f6f614c
قاعدة البيانات:
OpenAIRE
