Non-Conventional Treatments for Conventional Chondrosarcoma
| العنوان: | Non-Conventional Treatments for Conventional Chondrosarcoma |
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| المؤلفون: | Angela C. Hirbe, Mohammed M. Milhem, Hariharasudan Mani, Varun Monga |
| المصدر: | Cancers Cancers, Vol 12, Iss 1962, p 1962 (2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, musculoskeletal diseases, Cancer Research, medicine.medical_specialty, animal structures, Medullary cavity, medicine.medical_treatment, Review, chemotherapy, lcsh:RC254-282, Targeted therapy, 03 medical and health sciences, cyclin-dependent kinase inhibitors, 0302 clinical medicine, medicine, Grading (tumors), Chemotherapy, chondrosarcoma, business.industry, Cartilage, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, musculoskeletal system, targeted therapy, Review article, Clinical trial, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, embryonic structures, isocitrate dehydrogenase, Radiology, immunotherapy, Chondrosarcoma, business |
| الوصف: | Chondrosarcomas are the most common malignant tumors of the cartilage, are seen predominantly in adults, and have varied clinical behavior. The majority of them affect the medullary canal of long bones and pelvic bones. The prognosis of chondrosarcoma is closely related to histological grading; however, the grading is subject to interobserver variability. Conventional chondrosarcomas are overall considered to be chemotherapy- and radiation-resistant, resulting in limited treatment options. The majority of advanced conventional chondrosarcomas are treated with chemotherapy without any survival benefit. Recent studies have evaluated molecular genetic findings which have improved the understanding of chondrosarcoma biology. Newer therapeutic targets are desperately needed. In this review article, we explore ongoing clinical trials evaluating novel ways of treating advanced conventional chondrosarcoma. |
| تدمد: | 2072-6694 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28e9188fdc85313928cc1c3ba5a8ecdTest https://pubmed.ncbi.nlm.nih.gov/32707689Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b28e9188fdc85313928cc1c3ba5a8ecd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726694 |
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