التفاصيل البيبلوغرافية
| العنوان: |
Ischemic preconditioning improves rat kidney graft function after severe ischemia/reperfusion injury |
| المؤلفون: |
Fuller, T.F.1,2,3 flofu@yahoo.com, Freise, C.E.1,2,3, Feng, S.1,2,3, Niemann, C.U.1,2,3 |
| المصدر: |
Transplantation Proceedings. Jan2005, Vol. 37 Issue 1, p377-378. 2p. |
| مصطلحات موضوعية: |
*KIDNEY transplantation, *ISCHEMIA, *REPERFUSION injury, *SERUM |
| مستخلص: |
Abstract: Ischemic preconditioning (IP) has been shown to ameliorate renal ischemia reperfusion injury. Using a rat kidney transplantation model we determined if IP improves graft function after prolonged cold storage. Materials and methods: Syngeneic rat kidneys were divided into two groups. Prior to 42 hours of cold storage in UW and transplantation, one group (n = 10) received IP (15 minutes of warm ischemia/10 minutes of reperfusion), whereas another group (n = 10) received no treatment. Early graft function and 1-week recipient survival were assessed. Results: Recipient survival was not significantly different between groups [70% (IP) vs 40% (non-IP); P = .28]. IP treatment led to a quicker recovery of renal function. On PODs 3 and 6, serum creatinine levels in the IP group were significantly lower compared with the untreated group. In conclusion, one cycle of IP (15/10) accelerates recovery of renal graft function after severe ischemia reperfusion injury. This simple treatment modality may improve outcomes of renal transplants with prolonged cold storage. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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