التفاصيل البيبلوغرافية
| العنوان: |
Cytokines in patients with HLA‐B27 + acute anterior uveitis. |
| المؤلفون: |
JAKOB, E1 (AUTHOR), UMANSKY, L2 (AUTHOR), BECKHOVE, P2 (AUTHOR), MACKENSEN, F1 (AUTHOR) |
| المصدر: |
Acta Ophthalmologica (1755375X). Sep2012 Supplement S249, Vol. 90, p0-0. 1p. |
| مصطلحات موضوعية: |
*HLA-B27 antigen, *IRIDOCYCLITIS, *SEX factors in disease, *CYTOKINES, *AGE factors in disease, *INTERLEUKIN-17 |
| الشركة/الكيان: |
AMATEUR Athletic Union of the United States |
| مستخلص: |
Purpose In this study, we assessed 27 different cytokines in peripheral blood of patients with HLA‐B27 + acute anterior uveitis (AAU), the most common form of immune‐mediated uveitis. Goal of the study was to determine if cytokine levels in peripheral blood are associated with disease activity in AAU. Methods Blood samples were collected from 14 consecutive patients with AAU in active and inactive disease phase (2 samples per patient at different time points) and from 14 age and gender matched controls. Patients with systemic treatment were not included. Samples were stored at ‐20 °C. Subjects were evaluated for cytokines in peripheral blood by Bio‐Plex Pro Human Cytokine 27‐Plex Panel. Percentages of each cytokine were compared for patients with active vs inactive disease and to age and gender matched group of healthy controls. IRB approval has been obtained. Results Comparing active to inactive disease status we found signifficantly higher levels in 12 of the 27 accessed cytokines in active disease compared to inactive. In active status, we found significantly higher levels of Il‐1b,IL‐1ra, IL‐5, IL‐6, IL‐7, IL‐9, IL‐1o, IL‐17 and IFN‐g. Interestingly, we did not see a significant difference in levels of IL‐2 and TNF alpha. In all but one tested cytokine (IL‐6), there was no significant difference between samples of patients in inactive disease and controls. Conclusion Results show that there are significant differences in serum levels of many different cytokines in patients with active and inactive AAU. [ABSTRACT FROM AUTHOR] |
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