دورية أكاديمية
Transcriptional regulation of DC fate specification
| العنوان: | Transcriptional regulation of DC fate specification |
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| المؤلفون: | Bosteels, Cedric, Scott, Charlotte |
| المصدر: | MOLECULAR IMMUNOLOGY ; ISSN: 0161-5890 |
| سنة النشر: | 2020 |
| المجموعة: | Ghent University Academic Bibliography |
| مصطلحات موضوعية: | Biology and Life Sciences, Medicine and Health Sciences, Immunology, Molecular Biology, Dendritic cells, Transcription Factors, DC fate, Irf4, Irf8, Zeb1, Zeb2, Notch, Tbet, Klf4, MHC CLASS-II, DENDRITIC-CELL-DEVELOPMENT, LYMPHOTOXIN-BETA-RECEPTOR, T-CELLS, SIGNALING CONTROLS, FACTOR E2-2, IFN-GAMMA, DIFFERENTIATION, EXPRESSION |
| الوصف: | Dendritic cells function in the immune system to instruct adaptive immune cells to respond accordingly to different threats. While conventional dendritic cells can be subdivided into two main subtypes, termed cDC1s and cDC2s, it is clear that further heterogeneity exists within these subtypes, particularly for cDC2s. Understanding the signals involved in specifying each of these lineages and subtypes thereof is crucial to (i) enable us to determine their specific functions and (ii) put us in a position to be able to target these cells to promote or prevent a specific function in any given disease setting. Although we still have much to learn regarding the specification of these cells, here we review the most recent advances in our understanding of this and highlight some of the next questions for the future. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://biblio.ugent.be/publication/8662391Test; http://hdl.handle.net/1854/LU-8662391Test; http://dx.doi.org/10.1016/j.molimm.2020.02.021Test; https://biblio.ugent.be/publication/8662391/file/8662392Test |
| DOI: | 10.1016/j.molimm.2020.02.021 |
| الإتاحة: | https://doi.org/10.1016/j.molimm.2020.02.021Test https://biblio.ugent.be/publication/8662391Test http://hdl.handle.net/1854/LU-8662391Test https://biblio.ugent.be/publication/8662391/file/8662392Test |
| حقوق: | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Public License (CC BY-NC-ND 4.0) ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.341AF5F7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.molimm.2020.02.021 |
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