Neonatal thyroid-stimulating hormone concentrations in Belgium: a useful indicator for detecting mild iodine deficiency?
| العنوان: | Neonatal thyroid-stimulating hormone concentrations in Belgium: a useful indicator for detecting mild iodine deficiency? |
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| المؤلفون: | Jean Vanderpas, Marie-Françoise Vincent, Ann Meulemans, Timothy Vanwynsberghe, Caroline Trumpff, Brigitte Wuyts, Valbona Selimaj, Bart Van Overmeire, Roland Schoos, Stefanie Vandevijvere, François Eyskens, Sandrine Marie, Wim Coucke, Christine Kirkpatrick, Herman Van Oyen, François Boemer, Maarten Fauvart, Eddy Philips, Rodrigo Moreno-Reyes |
| المساهمون: | UCL - (SLuc) Service de biochimie médicale, Nizami, Qamaruddin |
| المصدر: | PLoS One, Vol. 7, no.10, p. e47770 [1-6] (2012) PLoS ONE PLoS ONE, Vol 7, Iss 10, p e47770 (2012) PloS one, 7 (10 |
| بيانات النشر: | Public Library of Science, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | endocrine system diseases, Epidemiology, Thyrotropin, Pediatrics, Endocrinology, Pediatric Endocrinology, Belgium, Pregnancy, Congenital Hypothyroidism -- blood -- diagnosis, Pediatric Epidemiology, Thyroid, education.field_of_study, Multidisciplinary, Child Health, Sciences bio-médicales et agricoles, Congenital hypothyroidism, Micronutrient Deficiencies, Medicine, Female, Public Health, Seasons, hormones, hormone substitutes, and hormone antagonists, Research Article, medicine.medical_specialty, endocrine system, Birth weight, Science, Population, chemistry.chemical_element, Iodine, Thyroid-stimulating hormone, Internal medicine, medicine, Congenital Hypothyroidism, Humans, Least-Squares Analysis, education, Thyrotropin -- blood -- diagnostic use, Nutrition, business.industry, Infant, Newborn, medicine.disease, Iodine deficiency, Survey Methods, chemistry, Preventive Medicine, Neonatology, business, Hormone |
| الوصف: | It has been proposed that neonatal thyroid-stimulating hormone (TSH) concentrations are a good indicator of iodine deficiency in the population. A frequency of neonatal TSH concentrations above 5 mU/L below 3% has been proposed as the threshold indicating iodine sufficiency. The objective of the present study was to evaluate feasibility and usefulness of nation-wide neonatal TSH concentration screening results to assess iodine status in Belgium. All newborns born in Belgium during the period 2009-2011 (n = 377713) were included in the study, except those suffering from congenital hypothyroidism and premature neonates. The frequency of neonatal TSH concentrations above 5 mU/L from 2009 to 2011 in Belgium fluctuated between 2.6 and 3.3% in the centres using the same TSH assay. There was a significant inverse association between neonatal TSH level and birth weight. The longer the duration between birth and screening, the lower the TSH level. Neonatal TSH levels were significantly lower in winter than in spring or autumn and significantly lower in spring and summer than in autumn while significantly higher in spring compared to summer. In conclusion, despite that pregnant women in Belgium are mildly iodine deficient, the frequency of neonatal TSH concentrations above 5 mU/L was very low, suggesting that the neonatal TSH threshold proposed for detecting iodine deficiency needs to be re-evaluated. Although neonatal TSH is useful to detect severe iodine deficiency, it should not be recommended presently for the evaluation of iodine status in mildly iodine deficient regions. Journal Article SCOPUS: ar.j info:eu-repo/semantics/published |
| وصف الملف: | 1 full-text file(s): application/pdf; Print-Electronic; application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11240d559d8c9426fc7bb4913890dbeTest https://hdl.handle.net/2078.1/158473Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e11240d559d8c9426fc7bb4913890dbe |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |