التفاصيل البيبلوغرافية
| العنوان: |
Plantamajoside Reduces Gastric Cancer Cell Migration and Invasion by Inhibiting PI3K/AKT and ERK Pathways. |
| المؤلفون: |
Chenglu Tang1, Yuanyuan Wang1, Jing Huang1, Xiaohong Lv1 Lvxiaohong_666@163.com |
| المصدر: |
Current Topics in Nutraceutical Research. May2023, Vol. 21 Issue 2, p175-181. 7p. |
| مصطلحات موضوعية: |
STOMACH tumors, DRUG efficacy, FLOW cytometry, LATEX, PROTEINS, CELL migration, COLONY-forming units assay, WESTERN immunoblotting, MICROBIOLOGICAL assay, CANCER invasiveness, GLYCOSIDES, APOPTOSIS, CELL survival, CELLULAR signal transduction, CELL migration inhibition, PLANT extracts, TRANSCRIPTION factors |
| مستخلص: |
Gastric cancer is a common malignancy with a poor survival rate. Plantamajoside, a phenylethanoid glycoside from Plantago asiatica, has been shown to inhibit the progression of many different types of cancer; however, its effect on gastric cancer remains to be explored. To this end, the effect of plantamajoside on the proliferation, apoptosis, stemness, mobility, and invasion of gastric cancer was evaluated by cell survival assay, flow cytometry, colony formation, sphere formation, transwell, and Western blot assays. Also, the potential molecular mechanism was addressed by Western blot assays for the expression of various signal proteins. Plantamajoside reduced cell viability, enhanced apoptosis, reduced cell mobility, and increased invasion of both AGS and HS746T cells in a dose-dependent manner. Plantamajoside also decreased the diameter of the spheroid and the relative expression of octamer-binding transcription factor-4 and the cluster of differentiation 44 proteins in both AGS and HS746T cells. Furthermore, plantamajoside downregulated the relative protein levels of p-PI3K/PI3K, p-AKT/AKT, and p-ERK/ERK in both AGS and HS746T cells. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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