التفاصيل البيبلوغرافية
| العنوان: |
The spliceosome as target for anticancer treatment. |
| المؤلفون: |
van Alphen, R. J.1, Wiemer, E. A. C.1, Burger, H.1, Eskens, F. A. L. M.1 f.eskens@erasmusmc.nl |
| المصدر: |
British Journal of Cancer. 1/27/2009, Vol. 100 Issue 2, p228-232. 5p. 2 Diagrams. |
| مصطلحات موضوعية: |
*NUCLEOPROTEINS, *RNA splicing, *MESSENGER RNA, *INTRONS, *ANTINEOPLASTIC agents, *CARCINOGENESIS, *THERAPEUTIC use of antineoplastic agents, *DRUG design, *CELL nuclei, *GENES, *TUMORS, *CARRIER proteins |
| مستخلص: |
The spliceosome is a ribonucleoprotein complex involved in RNA splicing, that is, the removal of non-coding introns from precursor messenger RNA. (Alternative) Splicing events may play an essential role in tumourigenesis. The recent discovery that the spliceosome is a target for novel compounds with anticancer activity opens up new therapeutic avenues. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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