التفاصيل البيبلوغرافية
| العنوان: |
Surgical Treatment vs Nonsurgical Treatment for Brain Arteriovenous Malformations in Patients with Hereditary Hemorrhagic Telangiectasia: A Retrospective Multicenter Consortium Study. |
| المؤلفون: |
Meybodi, Ali Tayebi, Kim, Helen, Nelson, Jeffrey, Hetts, Steven W, Krings, Timo, terBrugge, Karel G, Faughnan, Marie E, Lawton, Michael T, Brain Vascular Malformation Consortium HHT Investigator Group |
| المصدر: |
Neurosurgery, vol 82, iss 1 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2018 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Brain Vascular Malformation Consortium HHT Investigator Group, Brain, Humans, Intracranial Arteriovenous Malformations, Central Nervous System Vascular Malformations, Telangiectasia, Hereditary Hemorrhagic, Treatment Outcome, Retrospective Studies, Databases, Factual, Adolescent, Adult, Aged, Middle Aged, Child, Preschool, Infant, Female, Male, Young Adult, AVM grading, Arteriovenous malformation, Brain vascular malformation consortium, Embolization, Hereditary hemorrhagic telangiectasia, Microsurgical resection, Radiosurgery, Rendu-Osler-Weber disease, Neurosciences |
| جغرافية الموضوع: |
35 - 47 |
| الوصف: |
BackgroundCerebral arteriovenous malformations (AVMs) are common in patients with hereditary hemorrhagic telangiectasia (HHT). However, due to the rarity of HHT and little published evidence of outcomes from management of brain AVMs in this disease, current international HHT guidelines recommend an individualized approach. Specifically, the outcomes for surgical vs nonsurgical management of these lesions have not been reported to date.ObjectiveTo report long-term outcomes of surgical resection of brain AVMs in HHT patients compared to outcomes in nonsurgically treated patients.MethodsFrom the database of the Brain Vascular Malformation Consortium HHT project, 19 patients with 20 resected AVMs (group 1) and 22 patients with 33 AVMs who received nonsurgical treatment (group 2) were studied. The groups were retrospectively reviewed for changes in functional status (modified Rankin Scale score) during the follow-up period.ResultsDuring the follow-up period, 9% of patients in group 1 suffered from worsening of functional status, whereas this figure was 16% for group 2 (P > .05). Functional outcomes were not statistically different between the 2 groups at the latest follow-up (P > .05).ConclusionHHT patients treated surgically for brain AVMs appear to have long-term functional outcomes comparable to nonsurgical (including observational) therapy with fewer unfavorable outcomes. It is therefore reasonable to consider surgical resection as a management option in the multidisciplinary team's individualized treatment strategy for HHT patients with brain AVMs. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt4hr4f52f; https://escholarship.org/uc/item/4hr4f52fTest |
| الإتاحة: |
https://escholarship.org/uc/item/4hr4f52fTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.FC2F94D2 |
| قاعدة البيانات: |
BASE |
