دورية أكاديمية
The predictive value of the CTA Vasospasm Score on delayed cerebral ischaemia and functional outcome after aneurysmal subarachnoid hemorrhage
| العنوان: | The predictive value of the CTA Vasospasm Score on delayed cerebral ischaemia and functional outcome after aneurysmal subarachnoid hemorrhage |
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| المؤلفون: | van der Harst, J Joep, Luijckx, Gert-Jan R, Elting, Jan Willem J, Lammers, Thijs, Bokkers, Reinoud P H, van den Bergh, Walter M, Eshghi, Omid S, Metzemaekers, Jan D M, Groen, Rob J M, Mazuri, Aryan, Veeger, Nic J G M, van Dijk, J Marc C, Uyttenboogaart, Maarten |
| المصدر: | van der Harst , J J , Luijckx , G-J R , Elting , J W J , Lammers , T , Bokkers , R P H , van den Bergh , W M , Eshghi , O S , Metzemaekers , J D M , Groen , R J M , Mazuri , A , Veeger , N J G M , van Dijk , J M C & Uyttenboogaart , M 2022 , ' The predictive value of the CTA Vasospasm Score on delayed cerebral ischaemia and functional outcome after aneurysmal subarachnoid hemorrhage ' , European Journal .... |
| سنة النشر: | 2022 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | cerebral infarction, computed tomography angiography, outcome assessment, health care, subarachnoid hemorrhage, vasospasm, intracranial, CLINICAL-TRIALS, SCALE |
| الوصف: | Background and purpose: Delayed cerebral ischaemia (DCI) is a severe complication of aneurysmal subarachnoid hemorrhage that can significantly impact clinical outcome. Cerebral vasospasm is part of the pathophysiology of DCI and therefore a computed tomography angiography (CTA) Vasospasm Score was developed and an exploration was carried out of whether this score predicts DCI and subsequent poor outcome after aneurysmal subarachnoid hemorrhage. Methods: The CTA Vasospasm Score sums the degree of angiographic cerebral vasospasm of 17 intradural arterial segments. The score ranges from 0 to 34 with a higher score reflecting more severe vasospasm. Outcome measures were cerebral infarction due to DCI (CI-DCI), radiological and clinical DCI, and unfavorable functional outcome defined as a modified Rankin Scale >2 at 6 months. Receiver operating characteristic analyses were used to assess predictive value and to determine optimal cut-off scores. Inter-rater reliability was evaluated by Cohen's kappa coefficient. Results: This study included 59 patients. CI-DCI occurred in eight patients (14%), DCI in 14 patients (24%) and unfavorable outcome in 12 patients (20%). Median CTA Vasospasm Scores were higher in patients with (CI-)DCI and poor outcome. Receiver operating characteristic analysis revealed the highest area under the curve on day 5: CI-DCI 0.89 (95% confidence interval [CI] 0.79–0.99), DCI 0.68 (95% CI 0.50–0.87) and functional outcome 0.74 (95% CI 0.57–0.91). Cohen's kappa between the two raters was moderate to substantial (0.57–0.63). Conclusions: This study demonstrates that the CTA Vasospasm Score on day 5 can reliably identify patients with a high risk of developing (CI-)DCI and unfavorable outcome. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/27246baa-312b-40ca-b74b-e8a067a78aaeTest |
| DOI: | 10.1111/ene.15139 |
| الإتاحة: | https://doi.org/10.1111/ene.15139Test https://hdl.handle.net/11370/27246baa-312b-40ca-b74b-e8a067a78aaeTest https://research.rug.nl/en/publications/27246baa-312b-40ca-b74b-e8a067a78aaeTest https://pure.rug.nl/ws/files/193370385/ene.15139.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.DEE0FE94 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/ene.15139 |
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