التفاصيل البيبلوغرافية
| العنوان: |
DREIMT: a drug repositioning database and prioritization tool for immunomodulation. |
| المؤلفون: |
Troulé, Kevin, López-Fernández, Hugo, García-Martín, Santiago, Reboiro-Jato, Miguel, Carretero-Puche, Carlos, Martorell-Marugán, Jordi, Martín-Serrano, Guillermo, Carmona-Sáez, Pedro, Glez-Peña, Daniel, Al-Shahrour, Fátima, Gómez-López, Gonzalo |
| المصدر: |
Bioinformatics; 2/15/2021, Vol. 37 Issue 4, p578-579, 2p |
| مصطلحات موضوعية: |
IMMUNOREGULATION, DRUG analysis, GENE expression, DRUGS, IMMUNE system, INTERNET servers |
| مستخلص: |
Motivation Drug immunomodulation modifies the response of the immune system and can be therapeutically exploited in pathologies such as cancer and autoimmune diseases. Results DREIMT is a new hypothesis-generation web tool, which performs drug prioritization analysis for immunomodulation. DREIMT provides significant immunomodulatory drugs targeting up to 70 immune cells subtypes through a curated database that integrates 4960 drug profiles and ∼2600 immune gene expression signatures. The tool also suggests potential immunomodulatory drugs targeting user-supplied gene expression signatures. Final output includes drug–signature association scores, FDRs and downloadable plots and results tables. Availabilityand implementation http://www.dreimt.orgTest. Supplementary information Supplementary data are available at Bioinformatics online. [ABSTRACT FROM AUTHOR] |
|
Copyright of Bioinformatics is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder