No Association of Blood Type O With Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1
| العنوان: | No Association of Blood Type O With Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1 |
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| المؤلفون: | Gerlof D. Valk, Carolina R. C. Pieterman, Ad R. M. M. Hermus, Wouter W. de Herder, Olaf M. Dekkers, Rachel S van Leeuwaarde, Inne H.M. Borel Rinkes, Joanne M. de Laat, Menno R. Vriens, Bas Havekes, Peter H. Bisschop, Madeleine L. Drent, Sjoerd Nell, Anouk N A van der Horst-Schrivers |
| المساهمون: | Internal medicine, CCA - Disease profiling, Interne Geneeskunde, RS: NUTRIM - R1 - Metabolic Syndrome, Guided Treatment in Optimal Selected Cancer Patients (GUTS), Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Movement Sciences, Endocrinology, Internal Medicine |
| المصدر: | Nell, S, van Leeuwaarde, R S, Pieterman, C R C, de Laat, J M, Hermus, A R, Dekkers, O M, de Herder, W W, van der Horst-Schrivers, A N, Drent, M L, Bisschop, P H, Havekes, B, Borel Rinkes, I H M, Vriens, M R & Valk, G D 2015, ' No Association of Blood Type O With Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1 ', Endocrinology, vol. 100, no. 10, pp. 3850-5 . https://doi.org/10.1210/jc.2015-2615Test Journal of Clinical Endocrinology and Metabolism, 100(10), 3850-3855. The Endocrine Society Journal of Clinical Endocrinology & Metabolism, 100(10), 3850-3855. Oxford University Press Journal of Clinical Endocrinology and Metabolism, 100(10), 3850. The Endocrine Society Journal of Clinical Endocrinology and Metabolism, 100(10), 3850-3855. ENDOCRINE SOC Nell, S, van Leeuwaarde, R S, Pieterman, C R C, de Laat, J M, Hermus, A R, Dekkers, O M, de Herder, W W, van der Horst-Schrivers, A, Drent, M L, Bisschop, P H, Havekes, B, Rinkes, I H M B, Vriens, M R & Valk, G D 2015, ' No Association of Blood Type O With Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1 ', Journal of Clinical Endocrinology and Metabolism, vol. 100, no. 10, pp. 3850-3855 . https://doi.org/10.1210/jc.2015-2615Test Journal of clinical endocrinology and metabolism, 100(10), 3850-3855. The Endocrine Society Journal of Clinical Endocrinology and Metabolism, 100, 3850-5 Journal of Clinical Endocrinology and Metabolism, 100(10), 3850-3855. Endocrine Society Journal of Clinical Endocrinology and Metabolism, 100, 10, pp. 3850-5 Journal of Clinical Endocrinology and Metabolism, 100(10), 3850-3855 |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, GROUP ALLELES, Databases, Factual, Endocrinology, Diabetes and Metabolism, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Clinical Biochemistry, Neuroendocrine tumors, Biochemistry, COLORECTAL-CANCER, Endocrinology, Multiple endocrine neoplasia, Non-U.S. Gov't, education.field_of_study, LEWIS-B, Research Support, Non-U.S. Gov't, Middle Aged, Neuroendocrine Tumors, SURVIVAL, Blood Group Antigens, Female, ABH, EXPRESSION, Adult, medicine.medical_specialty, CARCINOMA, Population, PANCREATIC-CANCER RISK, MEN1 PATIENTS, Research Support, SDG 3 - Good Health and Well-being, Pancreatic cancer, Internal medicine, ABO blood group system, medicine, Journal Article, Multiple Endocrine Neoplasia Type 1, Humans, MEN1, GROUP-RELATED ANTIGENS, Genetic Predisposition to Disease, education, Genetic Association Studies, Aged, Blood type, business.industry, Biochemistry (medical), Cancer, medicine.disease, business, LUNG |
| الوصف: | Context:An association between ABO blood type and the development of cancer, in particular, pancreatic cancer, has been reported in the literature. An association between blood type O and neuroendocrine tumors in multiple endocrine neoplasia type 1 (MEN1) patients was recently suggested. Therefore, blood type O was proposed as an additional factor to personalize screening criteria for neuroendocrine tumors in MEN1 patients.Objective:The aim of this study was to assess the association between blood type O and the occurrence of neuroendocrine tumors in the national Dutch MEN1 cohort.Design:This is a cohort study using the Dutch National MEN1 database, which includes more than 90% of the Dutch MEN1 population. Demographic and clinical data were analyzed by blood type. Chi-square tests and Fisher exact tests were used to determine the association between blood type O and occurrence of neuroendocrine tumors. A cumulative incidence analysis (Gray's test) was performed to assess the equality of cumulative incidence of neuroendocrine tumors in blood type groups, taking death into account as a competing risk.Results:The ABO blood type of 200 of 322 MEN1 patients was known. Demographic and clinical characteristics were similar among blood type O and non-O type cohorts. The occurrence of neuroendocrine tumors of the lung, thymus, pancreas, and gastrointestinal tract was equally distributed across the blood type O and non-O type cohorts (Grays's test for equality; P = 0.72). Furthermore, we found no association between blood type O and the occurrence of metastatic disease or survival.Conclusions:An association between blood type O and the occurrence of neuroendocrine tumors in MEN1 patients was not confirmed. For this reason, the addition of the blood type to screening and surveillance practice seems not to be of additional value for identifying MEN1 patients at risk for the development of neuroendocrine tumors, metastatic disease, or a shortened survival. |
| وصف الملف: | image/pdf |
| اللغة: | English |
| تدمد: | 0021-972X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c2352c09b6cd92afa4afc81bd0ef8eTest https://doi.org/10.1210/jc.2015-2615Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....74c2352c09b6cd92afa4afc81bd0ef8e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0021972X |
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