نتائج البحث - "ARSENIC EXPOSURE"

1

Arsenic Exposure and Melanoma Among US Adults Aged 20 or Older, 2003-2016

المؤلفون: Christine M. Arcari, Eleanor G. Rogan, Dillon Clarey, Ashley Wysong, Ahmed Bedaiwi

المصدر: Public Health Rep

الوصف: Objectives Chronic exposure to arsenic has been reported as a risk factor for nonmelanoma skin cancer, notably squamous cell carcinoma. However, current knowledge is limited about the association between arsenic exposure and melanoma. Our objectives were to (1) measure the association between total urinary arsenic levels and melanoma compared with nonmelanoma skin cancer and no cancer and (2) analyze the association between water source and melanoma and nonmelanoma skin cancer. Methods We collected cross-sectional data from the 2003-2016 cycles of the National Health and Nutrition Examination Survey. We conducted univariate and multivariate logistic regressions. To evaluate the possible association of skin cancer with source of tap water, we calculated odds ratios for participants with melanoma and nonmelanoma skin cancer, compared with participants with no cancer. Results White race, higher education, higher socioeconomic status, and smoking history were associated with melanoma and nonmelanoma skin cancer in the full study population. After adjusting for age and race/ethnicity, the adjusted odds ratio of participants with >50 μg/L of total urinary arsenic for melanoma or nonmelanoma skin cancer was 1.87 (95% CI, 0.58-6.05) and 2.23 (95% CI, 1.12-4.45) times higher compared with no cancer, respectively. Participants with nonmelanoma skin cancer had 2.06 increased odds of reporting a nonmunicipal water source compared with participants without cancer. Conclusions We did not find a relationship between the incidence of melanoma and exposure to arsenic among US adults. Nonmunicipal water sources were associated with nonmelanoma skin cancer and should be further investigated.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8738187feb2d8fb986ceb3057899a4eTest
https://pubmed.ncbi.nlm.nih.gov/33971104Test

2

Vitamin B-6 Intake Is Modestly Associated with Arsenic Methylation in Uruguayan Children with Low-Level Arsenic Exposure

المؤلفون: Gauri Desai, Elena I. Queirolo, Amy E. Millen, Katarzyna Kordas, Marie Vahter, Jihnhee Yu, Fabiana Peregalli, Richard W. Browne, Nelly Mañay

المصدر: J Nutr

مصطلحات موضوعية: Male, Vitamin b, medicine.medical_specialty, Inorganic arsenic, Riboflavin, Medicine (miscellaneous), chemistry.chemical_element, 010501 environmental sciences, Methylation, Niacin, 01 natural sciences, Arsenicals, Arsenic, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Nutritional Epidemiology, Cacodylic Acid, Humans, Thiamine, 030212 general & internal medicine, Vitamin B12, Child, ARSENIC EXPOSURE, 0105 earth and related environmental sciences, Nutrition and Dietetics, Chemistry, food and beverages, Water, Dimethylarsinic Acid, Environmental Exposure, Vitamin B 6, Diet, Vitamin B 12, B vitamins, Cross-Sectional Studies, Endocrinology, Inactivation, Metabolic, Uruguay, Female, Energy Intake

الوصف: BACKGROUND: Detoxification of inorganic arsenic (iAs) occurs when it methylates to form monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA). Lower proportions of urinary iAs and MMA, and higher proportions of DMA indicate efficient methylation. The role of B-vitamins in iAs methylation in children with low-level arsenic exposure is understudied. OBJECTIVES: Our study objective was to assess the association between B-vitamin intake and iAs methylation in children with low-level arsenic exposure (

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9289f1a7564d3deb7db1a64932a46bdfTest
https://doi.org/10.1093/jn/nxz331Test

3

Zinc treatment modulates hematological and morphological changes in rat erythrocytes following arsenic exposure

المؤلفون: Devinder K. Dhawan, Payal Bhardwaj

المصدر: Toxicology and Industrial Health. 35:593-603

مصطلحات موضوعية: Male, medicine.medical_specialty, Erythrocytes, Antioxidant, Sodium arsenite, Health, Toxicology and Mutagenesis, medicine.medical_treatment, chemistry.chemical_element, Zinc, 010501 environmental sciences, Toxicology, 01 natural sciences, Arsenic, Hemoglobins, Leukocyte Count, 03 medical and health sciences, chemistry.chemical_compound, Internal medicine, medicine, Animals, Rats, Wistar, ARSENIC EXPOSURE, Glutathione Transferase, 030304 developmental biology, 0105 earth and related environmental sciences, chemistry.chemical_classification, 0303 health sciences, Arsenic toxicity, Public Health, Environmental and Occupational Health, Catalase, Glutathione, Rats, Enzyme, Endocrinology, chemistry, Toxicity, Microscopy, Electron, Scanning, Lipid Peroxidation

الوصف: The aim of this study was to understand the effects of zinc supplementation on antioxidant defense systems, hematological indices, and erythrocyte morphology in conditions of chronic arsenic toxicity. Male Wistar rats were segregated into four groups: control, arsenic treated, zinc supplemented, and arsenic + zinc treated. The animals in the arsenic-treated group were given arsenic orally in drinking water in the form of sodium arsenite at a dose level of 100 mg L−1, and zinc was administered to zinc-treated animals in the form of zinc sulfate orally in drinking water at a dose level of 227 mg L−1. The animals were subjected to different treatments for a period of 12 weeks, and various investigations were undertaken that included serum zinc content, activity of antioxidant enzymes, and hematological indices. Further, scanning electron microscopic (SEM) studies were performed to assess morphological changes in erythrocytes. Arsenic treatment significantly reduced serum zinc concentrations, which, however, were restored to near-normal levels upon zinc supplementation. The activities of enzymes involved in antioxidant defense systems were altered in the erythrocyte lysates of arsenic-treated rats, which interestingly revealed a significant improvement upon simultaneous zinc supplementation. A significant reduction in the counts of total leukocytes, neutrophils, and lymphocytes was observed following arsenic intoxication, which came back to near control levels following zinc supplementation. Also, protective effects of zinc were evident from SEM that revealed maintenance of topographical appearances of erythrocytes in conditions of arsenic toxicity. Thus, this study clearly shows the protection afforded by zinc on erythrocytes during arsenic-induced toxicity.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbfb1cc9a05aa7efa84f2ccda77d943fTest
https://doi.org/10.1177/0748233719878563Test

4

Dose-response meta-analysis of arsenic exposure in drinking water and hypertension

المؤلفون: Rasool Mohammadi, Yaser Mokhayeri, Mansour Ghaderpoori, Ali Jafari, Bahram Kamarehie, Mohammad Amin Karami, Afsaneh Amiri

المصدر: Heliyon, Vol 7, Iss 3, Pp e06409-(2021)
Heliyon

الوصف: Background Based on the cross-sectional and cohort studies, exposure to As via drinking water can cause hypertension. Methods We searched PubMed, ISI WOS, and Scopus for relevant studies up to 1 January 2018 using related keywords. The meta-analysis was done on 10 studies (n = 28255) that report Odds Ratio for hypertension. The extracted ORs between As concentration and hypertension were pooled using random effect models. Study heterogeneity was analyzed using I2. Results The estimated adjusted OR for association between As and hypertension was 1.44 (95% CI: 1.12, 1.84) with I2 = 71%. Dose-Response analysis showed a linear relationship between As and hypertension (OR = 1.0008 95% CI: 1.0003, 1.001). In general, by increase of each unit in arsenic concentration, odds of the hypertension would increase as 0.08%. Conclusion There was a significant relationship between As exposure and hypertension.
Arsenic, Meta-analysis, Health risk, Chronic exposure, Drinking water

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6453309a9af7558c132e8acb39cadaa7Test
http://www.sciencedirect.com/science/article/pii/S2405844021005144Test

5

Telomere length, arsenic exposure and risk of basal cell carcinoma of skin

المؤلفون: Tony Fletcher, Nalini Srinivas, Peter Rudnai, Thomas Hielscher, Rajesh Kumar, Eugene Gurzau, Silvia Calderazzo, Kvetoslava Koppova, Sivaramakrishna Rachakonda

المصدر: Carcinogenesis. 40:715-723

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Cancer Research, Skin Neoplasms, Physiology, chemistry.chemical_element, Polymorphism, Single Nucleotide, Arsenic, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Basal cell carcinoma, ARSENIC EXPOSURE, Aged, integumentary system, Arsenic toxicity, business.industry, Case-control study, Environmental Exposure, General Medicine, Odds ratio, Environmental exposure, Middle Aged, Telomere, medicine.disease, Increased risk, Endocrinology, 030104 developmental biology, chemistry, Carcinoma, Basal Cell, Case-Control Studies, 030220 oncology & carcinogenesis, Female, Skin cancer, business

الوصف: Telomere length per se a heritable trait has been reported to be associated with different diseases including cancers. In this study based on arsenic exposed 528 cases with basal cell carcinoma of skin (BCC) and 533 healthy controls, we observed a statistically significant association between decreased telomere length and increased BCC risk (OR = 5.92, 95% CI = 3.92-9.01, P1.32 µg/L) was statistically significantly associated with decreased telomere length (β = −0.026, 95% CI = − 0.05-0.003, P = 0.02). The interaction between arsenic exposure and telomere length on BCC risk was statistically significant (P = 0.02). Within each tertile based on arsenic exposure, the individuals with shorter telomeres were at an increased risk of BCC, with highest risk being in the highest exposed group (OR = 16.13, 95% CI = 6.71-40.00, PP P = 0.0002). The combined effect of highest arsenic exposure and shortest telomeres on the risk of BCC (OR = 10.56, 95% CI = 5.14-21.70) showed a statistically significant departure from additivity (interaction constant ratio 6.56, P = 0.03). Our results show that in the presence of arsenic exposure, decreased telomere length predisposes individuals to increased risk of BCC, with the effect being synergistic in individuals with highest arsenic exposure and shortest telomeres.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75cad81622becbc0c10f92572ee17e3eTest
https://doi.org/10.1093/carcin/bgz059Test

6

Effect of melatonin on arsenic-induced oxidative stress and expression of MT1 and MT2 receptors in the kidney of laboratory mice

المؤلفون: Sangita Sutradhar, Anindita Deb, Shiv Shankar Singh

المصدر: Biological Rhythm Research. 51:1216-1230

الوصف: Arsenic is a ubiquitous element of the environment present in both inorganic and organic forms. Arsenic exposure leads to oxidative stress and tissue damages in living organisms. Kidney is one of t...

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5463cca2c1b39475dc9f273f778c47abTest
https://doi.org/10.1080/09291016.2019.1566993Test

7

Risk of neurodegenerative disease due to tau phosphorylation changes and arsenic exposure via drinking water

المؤلفون: Davoud Pakzad, Vajihe Akbari, Mohammad Reza Sepand, Mehdi Aliomrani

المصدر: Toxicol Res (Camb)

الوصف: It is estimated that around 140 million people are drinking highly contaminated water with arsenic (As) as a natural earth’s crust component. On the other hand, the prevalence of neurodegenerative disorders, especially Alzheimer’s disease, is constantly increasing. The aim of the present study was to investigate the correlation between oral arsenic trioxide exposure and its impact on tau protein phosphorylation at Ser262. Fifty-four male mice were randomly divided into three groups and were freely accessed to food and contaminated water of 1 and 10 ppm arsenic trioxide for 3 months, except for control subjects. At the end of each month, As concentration and tau phosphorylation were checked with graphite furnace atomic absorption spectrometer and western blot analysis, respectively. Surprisingly, it was observed that the amount of measured brain arsenic in 10 ppm-exposed subjects was significantly increased after 3 months (P-value ˂ 0.0001). The significant changes in tau phosphorylation were not seen in the 1 ppm-exposed subjects, and it was observed that Ser262 phosphorylation significantly increased after 2 and 3 months in the 10 ppm group (P-value < 0.05). Our results demonstrated that arsenic accumulated in the brain time-dependently and increased Ser262 tau phosphorylation, which is very important in several tauopathies. In conclusion, it could be inferred that environmental arsenic exposure even at very low concentrations could be considered as a reason for increasing the risk of developing neurodegenerative disease.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7507962ac99d29adfb350a9a44733844Test
https://pubmed.ncbi.nlm.nih.gov/33884182Test

8

Aortic Strain -Threshold Analysis of Non-Cancer Outcome from Arsenic Exposure

المؤلفون: Jaeil Ahn, H. Ferdosi, I.J. Boroje, S.H. Lamm

المصدر: ISEE Conference Abstracts. 2020

مصطلحات موضوعية: medicine.medical_specialty, business.industry, Internal medicine, Non cancer, medicine, General Earth and Planetary Sciences, business, Gastroenterology, ARSENIC EXPOSURE, Aortic strain, General Environmental Science

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::8d2b572c81377904a2f807b4f66ca3b0Test
https://doi.org/10.1289/isee.2020.virtual.p-0557Test

9

Arsenic Exposure and Glucose Metabolism: Experimental Studies Suggest Implications for Type 2 Diabetes

المؤلفون: Lindsey Konkel

المصدر: Environmental Health Perspectives

الوصف: Background: The prevalence of type 2 diabetes (T2D) has more than doubled since 1980. Poor nutrition, sedentary lifestyle, and obesity are among the primary risk factors. While an estimated 70% of cases are attributed to excess adiposity, there is an increased interest in understanding the contribution of environmental agents to diabetes causation and severity. Arsenic is one of these environmental chemicals, with multiple epidemiology studies supporting its association with T2D. Despite extensive research, the molecular mechanism by which arsenic exerts its diabetogenic effects remains unclear. Objectives: We conducted a literature search focused on arsenite exposure in vivo and in vitro, using relevant end points to elucidate potential mechanisms of oral arsenic exposure and diabetes development. Methods: We explored experimental results for potential mechanisms and elucidated the distinct effects that occur at high vs. low exposure. We also performed network analyses relying on publicly available data, which supported our key findings. Results: While several mechanisms may be involved, our findings support that arsenite has effects on whole-body glucose homeostasis, insulin-stimulated glucose uptake, glucose-stimulated insulin secretion, hepatic glucose metabolism, and both adipose and pancreatic β-cell dysfunction. Discussion: This review applies state-of-the-science approaches to identify the current knowledge gaps in our understanding of arsenite on diabetes development. https://doi.org/10.1289/EHP4517Test

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbcad288fa5db7d0f4b04f6f7a0ead0aTest
https://doi.org/10.1289/ehp7160Test

10

Arsenic induces transgenerational behavior disorders in Caenorhabditis elegans and its underlying mechanisms

المؤلفون: Hao Ma, Zhong-Wei Chu, Xiao-Li Ren, Xiaolei Ye, Ruo-Yi Du, Xiong Zhang, Jing-Juan Ju, Li Wang, Xiang Zuo, Hong-Mei Wu, Jian-Hong Zhu, Chen-Ping Huang, Hai-Qing Zhong

المصدر: Chemosphere. 252

مصطلحات موضوعية: medicine.medical_specialty, Environmental Engineering, Health, Toxicology and Mutagenesis, 0208 environmental biotechnology, chemistry.chemical_element, 02 engineering and technology, 010501 environmental sciences, Biology, medicine.disease_cause, 01 natural sciences, Arsenic, Transgenerational epigenetics, Internal medicine, medicine, Environmental Chemistry, Animals, Dopaminergic neuron, Caenorhabditis elegans, Caenorhabditis elegans Proteins, ARSENIC EXPOSURE, 0105 earth and related environmental sciences, Mental Disorders, Dopaminergic, Public Health, Environmental and Occupational Health, Body area, General Medicine, General Chemistry, biology.organism_classification, Pollution, 020801 environmental engineering, Oxidative Stress, Endocrinology, chemistry, Oxidative stress, Water Pollutants, Chemical

الوصف: The present study aimed to identify the effects of arsenic on behaviors in Caenorhabditis elegans (C. elegans) and the transgenerational effects. The synchronized C. elegans (P generation) were exposed to 0, 0.2, 1.0, and 5.0 mM NaAsO2 and the subsequent generations (F1 and F2) were maintained on fresh nematode growth medium (NGM). The behaviors and growth were recorded at 0, 12, 24, 36, 48, 60, and 72 h post synchronization. The results demonstrated that arsenic affected various indicators regarding the behavior (head thrash, body bend, movement speed, wavelength, amplitude and so on) and in general the effects started to accumulate from 24 h and lasted throughout the exposure. The behavior impairments were transgenerational with varying patterns, amongst the head thrash and body bend responded most sensitively though the responses gradually declined across generations. Arsenic exposure inhibited the growth (body length, body width, and body area) in P C. elegans from 24 h to 60 h, however there was no difference between treatments groups and the control at 72 h. Arsenic led to a dose-dependent degeneration of dopaminergic neurons in C. elegans, and inhibition of BAS-1 and CAT-2 expressions. The expressions of GCS-1, GSS-1, and SKN-1 were induced by arsenic exposure. Overall, chronic arsenic exposure impaired the behaviors and there were transgenerational effects. The head thrash and body bend responded most sensitively. Arsenic induced behavioral disorders might be attributed to degeneration of dopaminergic neurons which was associated with oxidative stress.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c24f2a6b46de5242e471e54d0113ad8Test
https://pubmed.ncbi.nlm.nih.gov/32203783Test

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