Association Study Indicates a Protective Role of Phosphatidylinositol-4-Phosphate-5-Kinase against Tardive Dyskinesia
| العنوان: | Association Study Indicates a Protective Role of Phosphatidylinositol-4-Phosphate-5-Kinase against Tardive Dyskinesia |
|---|---|
| المؤلفون: | Anton J. M. Loonen, Valentina A. Toshchakova, Florian Lang, Lyubomir I. Aftanas, Svetlana A. Ivanova, N. V. Govorin, Olga Yu Fedorenko, Evgenia G. Boyarko, Arkadiy V. Semke, Nikolay A. Bokhan |
| المساهمون: | Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET) |
| المصدر: | International Journal of Neuropsychopharmacology International Journal of Neuropsychopharmacology, 18(6), 1-6. Cambridge University Press |
| بيانات النشر: | Oxford University Press (OUP), 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Dyskinesia, Drug-Induced, Movement disorders, PIP5K2A, genotype, medicine.medical_treatment, Pharmacology, Risk Factors, single nucleotide polymorphism, neurotoxicity, genetic variability, Pharmacology (medical), 1 phosphatidylinositol 4 phosphate 5 kinase type IIa, pathophysiology, Movement Disorders, adult, article, Middle Aged, unclassified drug, Phosphotransferases (Alcohol Group Acceptor), Psychiatry and Mental health, Phenotype, female, tardive dyskinesia, priority journal, Schizophrenia, disease severity, Abnormal Involuntary Movement Scale, medicine.symptom, Psychology, Research Article, Antipsychotic Agents, medicine.medical_specialty, Neurotoxicity Syndrome, gene polymorphism, medium spiny neurons, prevalence, gene frequency, Tardive dyskinesia, Polymorphism, Single Nucleotide, Risk Assessment, Young Adult, male, Internal medicine, otorhinolaryngologic diseases, medicine, Humans, Genetic Predisposition to Disease, human, Antipsychotic, Genetic Association Studies, Neurotoxicity, Protective Factors, medicine.disease, major clinical study, phosphatidylinositol 4 phosphate kinase, Siberia, schizophrenia, Endocrinology, Dyskinesia |
| الوصف: | Background: Tardive dyskinesia is a disorder characterized by involuntary muscle movements that occur as a complication of long-term treatment with antipsychotic drugs. It has been suggested to be related to a malfunctioning of the indirect pathway of the motor part of the cortical-striatal-thalamic-cortical circuit, which may be caused by oxidative stress-induced neurotoxicity. Methods: The purpose of our study was to investigate the possible association between phosphatidylinositol-4-phosphate-5-kinase type IIa (PIP5K2A) function and tardive dyskinesia in 491 Caucasian patients with schizophrenia from 3 different psychiatric institutes in West Siberia. The Abnormal Involuntary Movement Scale was used to assess tardive dyskinesia. Individuals were genotyped for 3 single nucleotide polymorphisms in PIP5K2A gene: rs10828317, rs746203, and rs8341. Results: A significant association was established between the functional mutation N251S-polymorphism of the PIP5K2A gene (rs10828317) and tardive dyskinesia, while the other 2 examined nonfunctional single nucleotide polymorphisms were not related. Conclusions: We conclude from this association that PIP5K2A is possibly involved in a mechanism protecting against tardive dyskinesia-inducing neurotoxicity. This corresponds to our hypothesis that tardive dyskinesia is related to neurotoxicity at striatal indirect pathway medium-sized spiny neurons. |
| وصف الملف: | application/pdf |
| تدمد: | 1469-5111 1461-1457 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59cb5d7807f1de7b72c322fd2c7f9e22Test https://doi.org/10.1093/ijnp/pyu098Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....59cb5d7807f1de7b72c322fd2c7f9e22 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14695111 14611457 |
|---|