Prognostic value of RASSF1A methylation status in non-small cell lung cancer (NSCLC) patients: A meta-analysis of prospective studies
| العنوان: | Prognostic value of RASSF1A methylation status in non-small cell lung cancer (NSCLC) patients: A meta-analysis of prospective studies |
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| المؤلفون: | Yuefei Zhou, Hao Hu, Rui Ding, Min Zhang |
| المصدر: | Biomarkers. 24:207-216 |
| بيانات النشر: | Informa UK Limited, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Oncology, endocrine system, medicine.medical_specialty, Health, Toxicology and Mutagenesis, Clinical Biochemistry, non-small cell lung cancer (NSCLC), Subgroup analysis, 030204 cardiovascular system & hematology, Biochemistry, Disease-Free Survival, 03 medical and health sciences, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Internal medicine, medicine, Humans, Promoter Regions, Genetic, Prospective cohort study, business.industry, Tumor Suppressor Proteins, Methylation, DNA Methylation, Prognosis, medicine.disease, Confidence interval, 030220 oncology & carcinogenesis, Meta-analysis, Biomarker (medicine), Female, Non small cell, business |
| الوصف: | Objective: Ras association domain family 1 A (RASSF1A) has been regarded as a biomarker predicting the prognosis of non-small cell lung cancer (NSCLC), but previous findings are inconsistent. This meta-analysis of prospective studies aimed to assess the value of RASSF1A methylation in predicting the prognosis of NSCLC patients.Methods: Studies were searched in PubMed and Web of Science. The estimates of the effects and the corresponding 95% confidence intervals (95% CIs) were used for the analyses. The overall effects of RASSF1A methylation on overall survival (OS) were estimated, after which subgroup analysis based on regions was conducted. Sensitivity analyses were conducted to restrict the studies with certain features.Results: A total of 16 studies with 2210 participants were included in this meta-analysis. The overall analysis result indicated that RASSF1A methylation had no statistically significant effects on OS of NSCLC patients (HR = 1.28; 95% CI 0.86–1.70), which were confirmed by the su... |
| تدمد: | 1366-5804 1354-750X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb0f43299b377e3a14634a976191517Test https://doi.org/10.1080/1354750x.2019.1583771Test |
| رقم الانضمام: | edsair.doi.dedup.....bbb0f43299b377e3a14634a976191517 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13665804 1354750X |
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