نتائج البحث - "Lactate dehydrogenase"

1

Impact of Sitagliptin on Non-diabetic Covid-19 Patients

المؤلفون: Hayder M Al-Kuraishy, Gaber El-Saber Batiha, Naeem Qusty, Ali I Al-Gareeb, Athanasios Alexiou

المصدر: Current Molecular Pharmacology. 15:683-692

الوصف: Objective: In coronavirus disease 2019 (Covid-19), SARS-CoV-2 may use dipeptidyl peptidase 4 (DPP4) as an entry-point in different tissues expressing these receptors. DPP4 inhibitors (DPP4Is), also named gliptins, like sitagliptin, have anti-inflammatory and antioxidant effects, thereby lessen inflammatory and oxidative stress in diabetic Covid-19 patients. Therefore, the present study aimed to illustrate the potential beneficial effect of sitagliptin in managing Covid-19 in non-diabetic patients. Methods: A total number of 89 patients with Covid-19 were recruited from a single center at the time of diagnosis. The recruited patients were assigned according to the standard therapy for Covid-19 and our interventional therapy into two groups; Group A: Covid-19 patients on the standard therapy (n=40) and Group B: Covid-19 patients on the standard therapy plus sitagliptin (n=49). The duration of this interventional study was 28 days according to the guideline in managing patients with Covid-19. Routine laboratory investigations, serological tests, Complete Blood Count (CBC), C-reactive Protein (CRP), D-dimer, lactate dehydrogenase (LDH), and serum ferritin were measured to observed Covid-19 severity and complications. Lung Computed Tomography (CT) and clinical scores were evaluated. Results: The present study illustrated that sitagliptin as an add-on to standard therapy improved clinical outcomes, radiological scores, and inflammatory biomarkers than standard therapy alone in non-diabetic patients with Covid-19 (P Conclusions: Sitagliptin as an add-on to standard therapy in managing non-diabetic Covid-19 patients may have a robust beneficial effect by modulating inflammatory cytokines with subsequent good clinical outcomes.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3ee2916ce6aed7d1e8bdb1c0b17125Test
https://doi.org/10.2174/1874467214666210902115650Test

2

DIAGNOSTIC UTILITY OF SERUM LACTATE DEHYDROGENASE LEVELS (LDL) IN DIFFERENTIATING MEGALOBLASTIC ANEMIA FROM MYELODYSPLASTIC SYNDROMES IN PAKISTAN

المؤلفون: Faraz Ali Rana, Madiha Ilyas, Muhammad Amir, Asad Mahmood, Nabeela Khan, Helan Mary Robert

المصدر: Pakistan Armed Forces Medical Journal, Vol 71, Iss 5, Pp 1539-1543 (2021)

الوصف: Objective: To study the diagnostic utility of lactate dehydrogenase levels in differentiating megaloblastic anemia from myelodysplastic anemia in Pakistan. Study Design: Comparative cross-sectional study. Place and Duration of Study: Department of Hematology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan from Feb, 2019 to Aug, 2019. Methodology: In this study, total 240 patients (18-75 years of age) males and females were selected by consecutive sampling technique and were equally divided into 3 groups; patients with megaloblastic anemia, patients with myelodysplastic syndromes and healthy control group. The clinical history and duration of anemia were recorded on special designed proforma. The laboratory investigations including lactate dehydrogenase levels were also noted. Both types of anemia were compared on basis of Lactate Dehydrogenase Levels. Results: The lactate dehydrogenase levels in megaloblastic group were more than 3000 IU/L in 58 out of 80 patients (72.5%). On other hand, myelodysplastic group had 79 out of 80 patients with lactic acid dehydrogenase levels below 450 IU/L (98.75%). The difference in lactic acid dehydrogenase levels between both groups was found to be statistically significant. Conclusion: Serum lactate dehydrogenase levels can be used to differentiate megaloblastic anemia from other anemia especially myelodysplastic syndromes before doing a bone marrow examination. High lactate dehydrogenase levels above 3000 IU/L in megaloblastic anemia can differentiate it from other anemia.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18be787a6b9d38fba8545a8279ca6a1dTest
https://doi.org/10.51253/pafmj.v71i5.5003Test

3

Risk factors for COVID-19 progression and mortality in hospitalized patients without pre-existing comorbidities

المؤلفون: Lijin Lin, Xiao-Jing Zhang, Weifang Liu, Xuewei Huang, Zhi-Gang She, Peng Zhang, Feng Wan, Bing-Hong Zhang, Hongliang Li, Yuan-gao Liao, Lei Wang, Yufeng Yuan, Chengzhang Yang

المصدر: Journal of Infection and Public Health
Journal of Infection and Public Health, Vol 15, Iss 1, Pp 13-20 (2022)

مصطلحات موضوعية: Male, BUN, blood urea nitrogen, CK, creatine phosphokinase, Infectious and parasitic diseases, RC109-216, HDLs, high-density lipoproteins, Procalcitonin, HDL-c, high-density lipoprotein cholesterol, ULN, upper limit of normal, Risk Factors, Interquartile range, SAA, serum amyloid A, IL-6, interleukin-6, SpO2, oxygen saturation, COVID-19, coronavirus disease 2019, LASSO, least absolute shrinkage and selection operator, LDH, lactate dehydrogenase, medicine.diagnostic_test, General Medicine, Middle Aged, Without comorbidities, ICU, intensive care unit, Infectious Diseases, Cohort, Absolute neutrophil count, Original Article, Public aspects of medicine, RA1-1270, Partial thromboplastin time, medicine.medical_specialty, RT-PCR, reverse transcription-polymerase chain reaction, ALT, alanine transaminase, WHO, World Health Organization, FiO2, inhaled oxygen concentration, cTnI, cardiac troponin I, Severity, PaO2, arterial partial pressure of oxygen, LLN, lower limit of normal, PT, prothrombin time, Internal medicine, cTnT, cardiac troponin T, medicine, Humans, Mortality, Risk factor, APTT, activated partial thromboplastin time, ARDS, acute respiratory distress syndrome, IQR, interquartile range, Retrospective Studies, Prothrombin time, ALP, alkaline phosphatase, SARS-CoV-2, business.industry, Public Health, Environmental and Occupational Health, COVID-19, Retrospective cohort study, OR, odds ratio, Oxygen Saturation, hs-cTnI, high sensitivity cardiac troponin I, CI, confidence intervals, SARS-COV-2, severe acute respiratory syndrome coronavirus 2, hs-cTnT, high-sensitivity troponin T, business, ECMO, extracorporeal membrane oxygenation, CT, chest tomography

الوصف: Background: Coronavirus disease 2019 (COVID-19) pandemic continues to escalate intensively worldwide. Massive studies on general populations with SARS-CoV-2 infection have revealed that pre-existing comorbidities were a major risk factor for the poor prognosis of COVID-19. Notably, 49–75% of COVID-19 patients had no comorbidities, but this cohort would also progress to severe COVID-19 or even death. However, risk factors contributing to disease progression and death in patients without chronic comorbidities are largely unknown; thus, specific clinical interventions for those patients are challenging. Methods: A multicenter, retrospective study based on 4806 COVID-19 patients without chronic comorbidities was performed to identify potential risk factors contributing to COVID-19 progression and death using LASSO and a stepwise logistic regression model. Results: Among 4806 patients without pre-existing comorbidities, the proportions with severe progression and mortality were 34.29% and 2.10%, respectively. The median age was 47.00 years [interquartile range, 36.00–56.00], and 2162 (44.99%) were men. Among 51 clinical parameters on admission, age ≥ 47, oxygen saturation < 95%, increased lactate dehydrogenase, neutrophil count, direct bilirubin, creatine phosphokinase, blood urea nitrogen levels, dyspnea, increased blood glucose and prothrombin time levels were associated with COVID-19 mortality in the entire cohort. Of the 3647 patients diagnosed with non-severe COVID-19 on admission, 489(13.41%) progressed to severe disease. The risk factors associated with COVID-19 progression from non-severe to severe illness were increased procalcitonin levels, SpO2 < 95%, age ≥ 47, increased LDH, activated partial thromboplastin time levels, decreased high-density lipoprotein cholesterol levels, dyspnea and increased D-dimer levels. Conclusions: COVID-19 patients without pre-existing chronic comorbidities have specific traits and disease patterns. COVID-19 accompanied by severe bacterial infections, as indicated by increased procalcitonin levels, was highly associated with disease progression from non-severe to severe. Aging, impaired respiratory function, coagulation dysfunction, tissue injury, and lipid metabolism dysregulation were also associated with disease progression. Once factors for multi-organ damage were elevated and glucose increased at admission, these findings indicated a higher risk for mortality. This study provides information that helps to predict COVID-19 prognosis specifically in patients without chronic comorbidities.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0558c35e7552d6170a8a851d53c6187eTest
https://doi.org/10.1016/j.jiph.2021.11.012Test

4

Development of Intravascular Large B-cell Lymphoma during Methotrexate Treatment for Rheumatoid Arthritis

المؤلفون: Kosuke Obama, Tomohisa Tabuchi, Hirosaka Inoue

المصدر: Internal Medicine. 61:87-90

الوصف: A 56-year-old woman with rheumatoid arthritis who had been taking methotrexate (MTX) for six years visited our hospital with dyspnea and dizziness. Abdominal ultrasonography revealed mild splenomegaly. Laboratory examinations showed a marked elevation in soluble interleukin-2 receptor and lactate dehydrogenase levels. These abnormalities revealed a spontaneous regression after MTX discontinuation, however, they worsened again four months later. Skin biopsies revealed a diagnosis of intravascular large B-cell lymphoma (IVLBCL), and we diagnosed MTX-associated IVLBCL (MTX-IVLBCL) based on its characteristic course. Despite the recurrence of IVLBCL, it showed a good response to chemotherapy. MTX-IVLBCL should therefore be treated with consideration since it has different characteristics from that of de novo IVLBCL.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e5555c21e0bc1c64fb43ac0182b2ccTest
https://doi.org/10.2169/internalmedicine.7531-21Test

5

Clinical features, laboratory findings and persistence of virus in 10 children with coronavirus disease 2019 (COVID-19)

المؤلفون: Anxing Fei, Sheng Li, Xiaoqing Zhang, Qihua Fu, Qing Cao, Shixiong Yang, Hongbin Cheng, Shinuan Fei, Hong Jiang, Jiang Wu, Ming Yuan, Jun Li, Lixia Zhang

المصدر: Biomedical Journal, Vol 44, Iss 1, Pp 94-100 (2021)
Biomedical Journal

مصطلحات موضوعية: Male, 0301 basic medicine, Medicine (General), medicine.disease_cause, chemistry.chemical_compound, 0302 clinical medicine, Medicine, Biology (General), Child, Children, Subclinical infection, Coronavirus, Leukopenia, LDH, lactate dehydrogenase, medicine.diagnostic_test, General Medicine, PCT, procalcitonin, COVID-19, Coronavirus Disease 2019, Child, Preschool, 030220 oncology & carcinogenesis, CRP, C-reactive protein, WHO, world health organization, Original Article, Female, medicine.symptom, Cohort study, medicine.medical_specialty, QH301-705.5, Nasal congestion, Asymptomatic, Hydroxybutyrate Dehydrogenase, 03 medical and health sciences, R5-920, Internal medicine, Lactate dehydrogenase, Humans, SARS, severe acute respiratory syndrome, α-HBDH, alpha-hydroxybutyrate dehydrogenase, Retrospective Studies, ESR, erythrocyte sedimentation rate, ALP, alkaline phosphatase, L-Lactate Dehydrogenase, SARS-CoV-2, business.industry, MERS, Middle East respiratory syndrome, COVID-19, Infant, Nucleic acid test, COVID-19 Drug Treatment, 030104 developmental biology, chemistry, business

الوصف: Background A pandemic caused by SARS-CoV-2 infection (COVID-19) has rapidly spread across the globe. Although many articles have established the clinical characteristics of adult COVID-19 patients so far, limited data are available for children. The aim of this study was to reveal the clinical features, laboratory findings and nucleic acid test results of ten pediatric cases. Methods In this retrospective single-center cohort study, pediatric cases with COVID-19 infection were consecutively enrolled in one hospital in Huangshi, China from January 1 to March 11, 2020. Results A total of 10 children with COVID-19 were recruited. Of them, four were the asymptomatic type, one was the mild type, and five were the moderate type (including two subclinical ones). All patients were from family clusters. Only fever, nasal discharge and nasal congestion were observed. Lymphopenia and leukopenia were uncommon in our sample but elevated levels of lactate dehydrogenase (LDH) and alpha-hydroxybutyrate dehydrogenase (α-HBDH) were observed frequently. Of these laboratory test variables, no statistical difference was identified between asymptomatic and symptomatic patients. Abnormalities in radiological data were detected in five patients, and representative findings of chest CT images were patchy shadows and ground-glass opacities. There were two cases whose oropharyngeal nucleic acid tests reversed to positive after one negative result, and two patients whose oropharyngeal swabs tested negative but rectal swabs showed positive. Conclusions Clinical symptoms were mild in children with COVID-19. Increased levels of LDH and α-HBDH were potential clinical biomarkers for pediatric cases. More attention should be paid to the SARS-CoV-2 viral assessment of rectal swabs before patients are discharged.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac47548008d9cae7f1840ee0fb45e61Test
https://doi.org/10.1016/j.bj.2020.10.007Test

6

Diagnostic signifcance of new hematological parameters in coronavirus infection

المصدر: Medical alphabet. 1:12-18

الوصف: Bacterial infection, and as a result, sepsis is a formidable complication in patients with new coronavirus infection, and one of the leading factors in hospital mortality. In the context of the COVID-19 pandemic, the economic costs of health care for biochemical monitoring have increased signifcantly. There is a need for a new approach to the analysis and, possibly, structuring of the results of routine studies obtained through a general blood test. The aim of the work is to assess the diagnostic capabilities of the new hematological parameters NEUT-RI – neutrophil reactivity and NEUT-GI – neutrophil granularity obtained using the Sysmex XN hematological analyzer from the standpoint of sepsis diagnostics. We analyzed laboratory data from a sample of patients with coronavirus infection (n = 449). Subsequently, the general statistical population was divided into two groups according to the level of procalcitonin – PCT (cut off = 0.5 ng/ml). With PCT < 0.5 ng/ml, the presence of sepsis was considered as ‘unlikely’, with PCT > 0.5 ng/ml as ‘highly likely’ event. For mathematical data processing, traditional statistical analysis, ROC analysis and the author’s ‘probabilistic approach’ were used. According to the data obtained, at PCT < 0.5 ng/ml, there is a correlation of average strength between C-reactive protein and procalcitonin (r = 0.49, p < 0.05). In the range of high concentrations of procalcitonin (PCT > 0.5 ng/ml), the mathematical relationship between similar biochemical markers is lost. The absence of the informative value of lactate dehydrogenase in terms of the diagnosis of sepsis has been established. According to the research results, NEUT-RI ≥ 56.9 Fl with a probability of 72% (specifcity 62.0%, sensitivity 83.5%) indicates the presence of sepsis. The probability of an alternative prognosis (presence or absence of sepsis) in one or another interval of the NEUT-RI and NEUT-GI values was calculated. The narrow quantitative ranges of the NEUT-RI parameter were identifed, in which the probability of sepsis is absent – 0% (35–45 Fl) and very high – 77% (65–75 Fl).

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ee3a3ec9036360e89f4498d4ecf0e3e8Test
https://doi.org/10.33667/2078-5631-2021-30-12-18Test

7

Prevalence of hepatopancreatic injury and clinical outcomes in patients with COVID-19 in USA

المؤلفون: Devina Singh, Lexie Finer, Hale Z Toklu, Latha Ganti, Vaibhav Rastogi, Dipendra Parajuli, Ranjit Banwait

المصدر: International Journal of Emergency Medicine, Vol 14, Iss 1, Pp 1-7 (2021)
International Journal of Emergency Medicine

الوصف: Background (1) To determine the prevalence of hepatopancreatic injury in coronavirus disease 2019 (COVID-19) patients. (2) To correlate hepatopancreatic injury in COVID-19 with mortality, disease severity, and length of stay in this cohort. Results Forty-five thousand three hundred sixty patients were included in the analysis, 62.82% of which had either hepatic or pancreatic injury. There was a significant upward trend in transaminases, alkaline phosphatase, prothrombin time, bilirubin, lactate dehydrogenase, and lipase and a downward trend in albumin with an increase in disease severity. COVID-19-positive patients with hepato-pancreatic injury have a significantly higher mortality (OR 3.39, 95%CI 3.15–3.65) after controlling for the differences in age, sex, race/ethnicity, liver cirrhosis, and medication exposures. They also have increased disease severity (OR 2.7, 95%CI 2.5–2.9 critical vs mild/moderate; OR 1.4, 95% CI 1.3–1.5 severe vs mild/moderate) and longer hospital length of stay (2 days). Conclusion COVID-19 can cause liver injury. Mortality, disease severity, and hospital length of stay are increased in COVID-19 patients with hepatopancreatic injury. Graphical Abstract

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feee61e9b11be48a7dd668e3f31471f0Test
https://doaj.org/article/84440671453442d6a475304089dd969fTest

8

The Clinical Characteristics and Risk Factors of Severe COVID-19

المؤلفون: Jianhua Hu, Yanggan Wang

المصدر: Gerontology

مصطلحات موضوعية: Male, Aging, Disease, Comorbidity, Gastroenterology, Risk Factors, Troponin I, medicine.diagnostic_test, Troponin T, Coronavirus disease 2019, 05 social sciences, Age Factors, Alanine Transaminase, Middle Aged, C-Reactive Protein, Cardiovascular Diseases, Creatinine, 2019-nCoV, Hypertension, Severe acute respiratory syndrome-CoV-2, Female, 0305 other medical science, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), 050105 experimental psychology, 03 medical and health sciences, Age Distribution, 030502 gerontology, Diabetes mellitus, Internal medicine, Lymphopenia, medicine, Diabetes Mellitus, Increased lactate dehydrogenase, Blood test, Humans, 0501 psychology and cognitive sciences, Aspartate Aminotransferases, Obesity, Sex Distribution, Aged, Clinical Section: Meta-Analysis, Pandemic, L-Lactate Dehydrogenase, business.industry, SARS-CoV-2, Albumin, COVID-19, medicine.disease, Coronavirus, Geriatrics and Gerontology, business

الوصف: Objective: We aim to investigate the clinical characteristics and risk factors for the severe cases of coronavirus disease 2019 (COVID-19) in comparison with the non-severe patients. Methods: We searched PubMed, EMBASE, Web of Science, and CNKI to collect all relevant studies published before July 26, 2020, and a total of 30 papers were included in this meta-analysis. Results: In the severe COVID-19 patients, 60% (95% CI = 56–64%) were male, 25% (95% CI = 21–29%) were over 65 years old, 34% (95% CI = 24–44%) were obese, and 55% (95% CI = 41–70%) had comorbidities. The most prevalent comorbidities were hypertension (34%, 95% CI = 25–44%), diabetes (20%, 95% CI = 15–25%), and cardiovascular disease (CVD; 12%, 95% CI = 9–16%). The most common blood test abnormalities were elevated C-reactive protein (CRP; 87%, 82–92%), decreased lymphocyte count (68%, 58–77%), and increased lactate dehydrogenase (69%, 95% CI = 57–81%). In addition, abnormal laboratory findings revealing organ dysfunctions were frequently observed in the severe cases, including decrease in albumin (43%, 95% CI = 24–63%) and increase in aspartate aminotransferase (47%, 95% CI = 38–56%), alanine aminotransferase (28%, 95% CI = 16–39%), troponin I/troponin T (TnI/TnT; 29%, 95% CI = 13–45%), and serum Cr (SCr; 10%, 95% CI = 5–15%). Conclusion: The male, elderly and obese patients and those with any comorbidities, especially with hypertension, diabetes, and CVD, were more likely to develop into severe cases. But the association between hypertension, diabetes, CVD, and severity of COVID-19 was declined by the increase of age. A significant elevation in cardiac TnI/TnT, the hepatic enzymes, and SCr and the reduction in lymphocytes with elevated CRPs are important markers for the severity. Specific attention should be given to the elderly male and obese patients and those with indications of severe immune injury in combination with bacterial infection and indication of multi-organ dysfunction or damages.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67675ee9df2298861c3e0442cc2903f7Test
http://europepmc.org/articles/PMC7900480Test

9

Biochemical predictors for Sars-Cov-2 severity

المؤلفون: Ezhil, Gurusamy, S, Mahalakshmi, Gurumoorthy, Kaarthikeyan, K, Ramadevi, Parkavi, Arumugam, M S, Gayathri

المصدر: Bioinformation. 17:834-839

الوصف: It is of interest to assess the inflammatory marker profile in SARS-CoV-2 patients and to correlate the levels of systemic inflammatory biomarkers such as neutrophil-to-lymphocyte ratio (NLR), C-Reactive Protein CRP, Ferritin, Creatine kinase (CK), Lactate dehydrogenase (LDH) and liver function analytes total serum proteins, albumin, total bilirubin, direct bilirubin, alkaline phosphatase, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) with the severity of SARS-CoV-2 infections. A total of 1000 COVID-19 positive patient’s data were collected. Laboratory assessments consisted of NLR (neutrophil-lymphocyte ratio) by cell counter, C Reactive Protein (CRP) by immunoturbidimetry, Ferritin by electrochemiluminescence (ECLIA) and Creatine Kinase (CK), Lactate Dehydrogenase (LDH), Alkaline phosphatase (ALP), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Total Bilirubin, Direct Bilirubin, Total Protein and Albumin by spectrophotometry. The mean plasma CRP levels, NLR, ferritin, CK and LDH levels were higher in severe cases than in non-severe cases, and the difference was statistically significant (p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc989d9c5c6175066a480d2d2cb59f1Test
https://doi.org/10.6026/97320630017834Test

10

Thrombogenicity markers for early diagnosis and prognosis in COVID-19: a change from the current paradigm?

المؤلفون: Paul A. Gurbel, Udaya S. Tantry, Kevin P. Bliden, Jerrold H. Levy, Nicole Rapista, Christophe Jerjian, Naval Walia, Alastair Cho

المصدر: Blood Coagulation & Fibrinolysis

مصطلحات موضوعية: Male, Organ Dysfunction Scores, Comorbidity, COVID-19 Testing, Medicine, Thrombophilia, Myocardial infarction, Prospective Studies, Prospective cohort study, Stroke, Aged, 80 and over, medicine.diagnostic_test, Hematology, General Medicine, Middle Aged, Prognosis, Thrombelastography, Hospitalization, Treatment Outcome, Cardiovascular Diseases, SOFA score, Female, Fibrin Clot Lysis Time, Adult, medicine.medical_specialty, Thrombogenicity, Hyperlipidemias, White People, Internal medicine, Diabetes Mellitus, Humans, Obesity, African--Americans, Aged, Fibrin, L-Lactate Dehydrogenase, business.industry, SARS-CoV-2, sequential organ failure assessment score, COVID-19, Fibrinogen, thromboelastography, Odds ratio, Original Articles, medicine.disease, Thromboelastography, Black or African American, Early Diagnosis, platelet fibrin clot strength, business, Biomarkers

الوصف: Standard biomarkers have been widely used for COVID-19 diagnosis and prognosis. We hypothesize that thrombogenicity metrics measured by thromboelastography will provide better diagnostic and prognostic utility versus standard biomarkers in COVID-19 positive patients. In this observational prospective study, we included 119 hospitalized COVID-19 positive patients and 15 COVID-19 negative patients. On admission, we measured standard biomarkers and thrombogenicity using a novel thromboelastography assay (TEG-6s). In-hospital all-cause death and thrombotic occurrences (thromboembolism, myocardial infarction and stroke) were recorded. Most COVID-19 patients were African--Americans (68%). COVID-19 patients versus COVID-19 negative patients had higher platelet-fibrin clot strength (P-FCS), fibrin clot strength (FCS) and functional fibrinogen level (FLEV) (Pâ≤â0.003 for all). The presence of high TEG-6âs metrics better discriminated COVID-19 positive from negative patients. COVID-19 positive patients with sequential organ failure assessment (SOFA) score at least 3 had higher P-FCS, FCS and FLEV than patients with scores less than 3 (Pâ≤â0.001 for all comparisons). By multivariate analysis, the in-hospital composite endpoint occurrence of death and thrombotic events was independently associated with SOFA score more than 3 [odds ratio (OR)â=â2.9, Pâ=â0.03], diabetes (ORâ=â3.3, Pâ=â0.02) and FCSâ>â40âmm (ORâ=â3.4, Pâ=â0.02). This largest observational study suggested the early diagnostic and prognostic utility of thromboelastography to identify COVID-19 and should be considered hypothesis generating. Our results also support the recent FDA guidance regarding the importance of measurement of whole blood viscoelastic properties in COVID-19 patients. Our findings are consistent with the observation of higher hospitalization rates and poorer outcomes for African--Americans with COVID-19.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c50d87ded7123183d2e8e337e49a6278Test
http://europepmc.org/articles/PMC8630843Test

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