Undetectable haptoglobin is associated with major adverse kidney events in critically ill burn patients
| العنوان: | Undetectable haptoglobin is associated with major adverse kidney events in critically ill burn patients |
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| المؤلفون: | Dépret, François, Dunyach, Chloé, De Tymowski, Christian, Chaussard, Maïté, Bataille, Aurélien, Ferry, Axelle, Moreno, Nabila, Cupaciu, Alexandru, Soussi, Sabri, Benyamina, Mourad, Mebazaa, Alexandre, Serror, Kevin, Chaouat, Marc, Garnier, Jean-Pierre, Pirracchio, Romain, Legrand, Matthieu, PRONOBURN group |
| المصدر: | Critical Care Critical care (London, England), vol 21, iss 1 Critical Care, Vol 21, Iss 1, Pp 1-8 (2017) |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Kidney Disease, PRONOBURN group, 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, Medical and Health Sciences, law.invention, Cohort Studies, 0302 clinical medicine, Risk Factors, law, Burn patients, biology, Respiration, Statistics, Haptoglobin, lcsh:Medical emergencies. Critical care. Intensive care. First aid, Acute kidney injury, Acute Kidney Injury, Middle Aged, Haemolysis, Intensive care unit, Intensive Care Units, Creatinine, Artificial, Female, Burns, Cohort study, Adult, Paris, medicine.medical_specialty, Physical Injury - Accidents and Adverse Effects, Renal and urogenital, Major adverse kidney event, Statistics, Nonparametric, 03 medical and health sciences, Clinical Research, Internal medicine, medicine, Humans, Nonparametric, Risk factor, Intensive care medicine, Retrospective Studies, Haptoglobins, business.industry, Research, 030208 emergency & critical care medicine, Retrospective cohort study, lcsh:RC86-88.9, medicine.disease, Emergency & Critical Care Medicine, Respiration, Artificial, Intravascular haemolysis, Injury (total) Accidents/Adverse Effects, biology.protein, business, Total body surface area |
| الوصف: | Background Intravascular haemolysis has been associated with acute kidney injury (AKI) in different clinical settings (cardiac surgery, sickle cell disease). Haemolysis occurs frequently in critically ill burn patients. The aim of this study was to assess the predictive value of haptoglobin at admission to predict major adverse kidney events (MAKE) and AKI in critically ill burn patients. Methods We conducted a retrospective, single-centre cohort study in a burn critical care unit in a tertiary centre, including all consecutive severely burned patients (total burned body surface > 20% and/or shock and/or mechanical ventilation at admission) from January 2012 to April 2017 with a plasmatic haptoglobin dosage at admission. Results A total of 130 patients were included in the analysis. Their mean age was 49 (34–62) years, their median total body surface area burned was 29% (15–51%) and the intensive care unit (ICU) mortality was 25%. Early haemolysis was defined as an undetectable plasmatic haptoglobin at admission. We used logistic regression to identify MAKE and AKI risk factors. In multivariate analysis, undetectable haptoglobin was associated with MAKE and AKI (respectively, OR 6.33, 95% CI 2.34–16.45, p |
| وصف الملف: | application/pdf |
| تدمد: | 1364-8535 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b21a7bb4ff621535abf1aaca9d3968Test https://doi.org/10.1186/s13054-017-1837-4Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....58b21a7bb4ff621535abf1aaca9d3968 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13648535 |
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