التفاصيل البيبلوغرافية
| العنوان: |
Increased IL-18 Levels in Seminal Plasma of Infertile Men with Genital Tract Infections. |
| المؤلفون: |
Matalliotakis, Ioannis M., Cakmak, Hakan, Fragouli, Yvoni, Kourtis, Argiris, Arici, Aydin, Huszar, Gabor |
| المصدر: |
American Journal of Reproductive Immunology; Jun2006, Vol. 55 Issue 6, p428-433, 6p, 2 Charts, 3 Graphs |
| مصطلحات موضوعية: |
INTERLEUKINS, CYTOKINES, INTERFERONS, SPERMATOZOA, MALE reproductive organ diseases |
| مستخلص: |
Problem Interleukin (IL)-18 is a novel cytokine, previously known as interferon (IFN)- γ inducing factor. We evaluated the levels of IL-18 and IFN- γ in seminal plasma (SP) of fertile and infertile men. Method of study Semen samples were obtained by masturbation from 80 men, and were examined for the levels of IL-18 and IFN- γ by enzyme-linked immunosorbent assay. Seven groups were included: (i) fertile men ( n = 18), (i) infertile men with genital tract infections ( n = 17), (iii) with varicocele ( n = 15), (iv) with Klinefelter syndrome ( n = 6), (v) with cryptorchidism ( n = 7), (vi) with mumps orchitis ( n = 7), and (vii) with idiopathic testicular lesions ( n = 10). Results Mean levels of IL-18 were higher in SP from infertile men with genital tract infections compared with SP from other groups except Klinefelter syndrome ( P < 0.05). However, no significant differences could be detected for IFN- γ. A significant positive correlations was found between IL-18 and IFN- γ in total patient population ( P < 0.001). Moreover, a negative correlation was observed between IL-18 and sperm concentrations, and motility ( P < 0.01 and <0.03, respectively). Furthermore, there was a positive and statistically significant association between IL-18 and IFN- γ levels in SP of infertile men with genital tract infections ( P < 0.0001). However, there was no relationship between IL-18 and IFN- γ, and semen parameters in the same group. Conclusion SP IL-18 levels were increased in men with urogenital infections. Thus, the elevated expression of IL-18 in SP may be used as a diagnostic marker in the male genital tract infections. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
