التفاصيل البيبلوغرافية
| العنوان: |
Altered expression of interleukin-18 in the peritoneal fluid of women with endometriosis |
| المؤلفون: |
Arici, Aydin1 aydin.arici@yale.edu, Matalliotakis, Ioannis1,2, Goumenou, Anastasia2, Koumantakis, Georgios2, Vassiliadis, Simon3, Mahutte, Neal G.1 |
| المصدر: |
Fertility & Sterility. Oct2003, Vol. 80 Issue 4, p889-894. 6p. |
| مصطلحات موضوعية: |
*PERITONEUM, *CARCINOGENESIS, *ENDOMETRIOSIS, *INTERLEUKINS |
| مستخلص: |
: Objective:Peritoneal fluid (PF) inflammatory factors may participate in the pathogenesis of endometriosis. The aim of this study was to investigate PF interleukin (IL)-18 levels in women with and without endometriosis.: Design:Controlled clinical study.: Setting:Women undergoing laparoscopy at a university hospital.: Patient(s):Fifty women with previously untreated endometriosis, 8 women on GnRH agonists for endometriosis, and 18 control women with normal pelvic anatomy who were undergoing tubal ligation.: Intervention(s):Peritoneal fluid IL-18 levels as measured by ELISA.: Main outcome measure(s):Peritoneal fluid IL-18 levels.: Result(s):Peritoneal fluid IL-18 levels were significantly higher in women with previously untreated endometriosis (mean ± SEM, 91.1 ± 6.5 pg/mL) than in control women (59.4 ± 2.0 pg/mL). Interestingly, women with superficial (100.0 ± 10.2 pg/mL) and deep peritoneal implants (94.0 ± 10.8 pg/mL) had significantly higher PF IL-18 levels than did women with endometriomas (57.8 ± 1.8 pg/mL). Similarly, women with stage I–II endometriosis (97.3 ± 8.0 pg/mL), but not women with stage III–IV endometriosis (74.9 ± 9.9 pg/mL), had significantly higher PF IL-18 levels than did control women. Peritoneal fluid IL-18 levels were significantly higher in the luteal phase than in the follicular phase but did not discriminate between women with pelvic pain or infertility.: Conclusion(s):Peritoneal fluid IL-18 is elevated in women with peritoneal, minimal- to mild-stage endometriosis. [Copyright &y& Elsevier] |
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