التفاصيل البيبلوغرافية
| العنوان: |
Deficiencies in Selenium and/or Vitamin E Lower the Resistance of Mice to Heligmosomoides polygyrus Infections. |
| المؤلفون: |
Smith, Allen1, Madden, Kathleen B.2, Au Yeung, Karla J.3, Aiping Zhao4, Elfrey, Justin4, Finkelman, Fred5, Levander, Orville1, Shea-Donohue, Terez1,4, Urban Jr., Joseph F.1 urbanj@ba.ars.usda.gov |
| المصدر: |
Journal of Nutrition. Apr2005, Vol. 135 Issue 4, p830-836. 7p. 4 Graphs. |
| مصطلحات موضوعية: |
*SELENIUM in human nutrition, *VITAMIN E deficiency, *COXSACKIEVIRUS diseases, *INFLUENZA, *WORMS, *INTERLEUKIN-4, *PARASITES |
| مستخلص: |
Previous etudies have shown that deficiencies in selenium (Se) and/or vitamin E (VE) can exacerbate the infectivity and pathogenesis of coxsackievirus B3 and influenza. Both Se and VE play a role in immune function and antioxidant defense. To determine whether these deficiencies would affect the normal course of infection with a metazoan parasite, mice were made deficient in Se and/or VE and inoculated with the gastrointestinal nematode parasite Heligmosomoides polygyrus. Both primary and secondary infections were assessed. Although the course of a primary infection with H. polygyrus was unaffected by diet, diets deficient in Se, VE, and both $e and VE (Se/VE double-deficiency) all caused delayed adult worm expulsion and increased fecundity during a secondary infection; suggesting an impaired intestinal response, H, polygyrus-induced IL-4 levels were diet-independent; but Se/VE double-deficiency blocked the H. polygyrus induced IL-4 receptor-associated decrease in sodium-dependent glucose absorption in the jejunum that contributes to worm expulsion. In contrast, Se/VE double-deficiency had no effect on the infection-induced, IL-4R-associated increase in epithelial cell permeability that accompanies the infection. These results suggest that both Se and VE are required for specific Ib4-related changes in intestinal physiology that promote host protection against H. polygyrus. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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