The Hippo Pathway in Innate Anti-microbial Immunity and Anti-tumor Immunity
| العنوان: | The Hippo Pathway in Innate Anti-microbial Immunity and Anti-tumor Immunity |
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| المؤلفون: | Qian Zhang, Ruyuan Zhou, Pinglong Xu |
| المصدر: | Frontiers in Immunology, Vol 11 (2020) Frontiers in Immunology |
| بيانات النشر: | Frontiers Media S.A., 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, lcsh:Immunologic diseases. Allergy, MST1, endocrine system, cGAS-STING, animal structures, Immunology, Review, Protein Serine-Threonine Kinases, Biology, anti-tumor immunity, Infections, 03 medical and health sciences, 0302 clinical medicine, Immunity, Neoplasms, nucleic acid sensing, Animals, Homeostasis, Humans, Immunology and Allergy, Hippo Signaling Pathway, innate immunity, Tissue homeostasis, Hippo signaling pathway, Innate immune system, Antitumor immunity, anti-microbial, Pattern recognition receptor, interferon, biochemical phenomena, metabolism, and nutrition, Immunity, Innate, antiviral immunity, body regions, Hippo-YAP signaling, 030104 developmental biology, Hippo signaling, bacteria, lcsh:RC581-607, Neuroscience, Signal Transduction, 030215 immunology |
| الوصف: | The Hippo pathway responds to diverse environmental cues and plays key roles in cell fate determination, tissue homeostasis, and organ regeneration. Aberrant Hippo signaling, on the other hand, has frequently been implicated in diversified pathologies such as cancer and immune dysfunction. Here, we summarize the recent but rapid progress in understanding the involvement of the Hippo pathway in innate immunity, with a special focus on the intrinsic mechanisms and mutual interactions between Hippo-YAP signaling and the innate immune response and its physiological impacts on anti-microbial immunity and anti-tumor immunity. Moving forward, we believe that systematic investigations under the physiological setting are needed to draw a clearer picture of the actions of Hippo in innate immunity. |
| اللغة: | English |
| تدمد: | 1664-3224 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b706e98d32ad532af7c0018cdd53ce0Test https://www.frontiersin.org/article/10.3389/fimmu.2020.01473/fullTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9b706e98d32ad532af7c0018cdd53ce0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
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