دورية أكاديمية
Cardiometabolic risk factors in Thai individuals with prediabetes treated in a high-risk, prevention clinic - unexpected relationship between HDL cholesterol and glycaemia in men
| العنوان: | Cardiometabolic risk factors in Thai individuals with prediabetes treated in a high-risk, prevention clinic - unexpected relationship between HDL cholesterol and glycaemia in men |
|---|---|
| المؤلفون: | Srivanichakorn, W, Godsland, IF, Washirasaksiri, C, Phisalprapa, P, Charatcharoenwitthaya, P, Pramyothin, P, Sitasuwan, T, Preechasuk, L, Elkeles, R, Alberti, KGMM, Johnston, DG, Oliver, NS |
| المصدر: | 779 ; 771 |
| بيانات النشر: | Wiley Open Access |
| سنة النشر: | 2018 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Endocrinology & Metabolism, Cardiometabolic risk factor, Glycemia, Prediabetes, FASTING PLASMA-GLUCOSE, BETA-CELL DYSFUNCTION, CARDIOVASCULAR-DISEASE, GLYCATED HEMOGLOBIN, INSULIN-RESISTANCE, CHINESE POPULATION, LIPID PROFILES, PROGRESSION, CRITERIA, HBA(1C), glycaemia, 1103 Clinical Sciences |
| جغرافية الموضوع: | Japan |
| الوصف: | BACKGROUND: Relationships between cardiometabolic risk and glycaemia have been rarely studied in people under clinical evaluation and treatment for cardiometabolic risk and with prediabetes. We investigated relationships between glycaemia and cardiometabolic risk factors in clinic participants with prediabetes. METHODS: This was a cross-sectional analysis of data collected at a centre in Thailand. Clinic attendees were at high-risk of diabetes or cardiovascular disease, with HbA1c 39-<48 mmol/mol or fasting plasma glucose (FPG) 5.6-<7.0 mmol/L. The relationships between glycaemia and cardiometabolic risk factors were explored. RESULTS: Of 357 participants, two or more insulin resistance-related metabolic disturbances were present in 84%; 61% took a statin and 75% an antihypertensive agent. Independently of age, gender, adiposity, medication use, possible NAFLD and gender-glycaemia interaction, neither FPG nor HbA1c were associated with variation in any other cardiometabolic risk factors. HDL cholesterol decreased with HbA1c in women (female*HbA1c interaction, p=0.03) but, unexpectedly, increased with FPG in men (male*FPG interaction, p=0.02). CONCLUSION: Overall, in Thai people treated for high-cardiometabolic risk and with prediabetes defined by FPG and/or HbA1c, neither FPG nor HbA1c were associated with other cardiometabolic risk factors. However, according to gender, HDL cholesterol showed the expected relationship with glycaemia in women but the reverse in men. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2040-1124 |
| العلاقة: | Journal of Diabetes Investigation; http://hdl.handle.net/10044/1/64465Test; https://doi.org/10.1111/jdi.12967Test |
| DOI: | 10.1111/jdi.12967 |
| الإتاحة: | https://doi.org/10.1111/jdi.12967Test http://hdl.handle.net/10044/1/64465Test |
| حقوق: | © 2018 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0 - https://creativecommons.org/licenses/by/4.0Test/). |
| رقم الانضمام: | edsbas.388BDF54 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20401124 |
|---|---|
| DOI: | 10.1111/jdi.12967 |