التفاصيل البيبلوغرافية
| العنوان: |
Insulin resistance: Review of the underlying molecular mechanisms. |
| المؤلفون: |
Yaribeygi, Habib1 habib.yari@yahoo.com, Farrokhi, Farin Rashid1, Butler, Alexandra E.2, Sahebkar, Amirhossein3,4,5 amir_saheb2000@yahoo.com |
| المصدر: |
Journal of Cellular Physiology. Jun2019, Vol. 234 Issue 6, p8152-8161. 10p. |
| مصطلحات موضوعية: |
*INSULIN resistance, *DIABETES, *METABOLIC disorders, *TUMOR necrosis factors, *OXIDATIVE stress, INSULIN biodegradation |
| مستخلص: |
Most human cells utilize glucose as the primary substrate, cellular uptake requiring insulin. Insulin signaling is therefore critical for these tissues. However, decrease in insulin sensitivity due to the disruption of various molecular pathways causes insulin resistance (IR). IR underpins many metabolic disorders such as type 2 diabetes and metabolic syndrome, impairments in insulin signaling disrupting entry of glucose into the adipocytes, and skeletal muscle cells. Although the exact underlying cause of IR has not been fully elucidated, a number of major mechanisms, including oxidative stress, inflammation, insulin receptor mutations, endoplasmic reticulum stress, and mitochondrial dysfunction have been suggested. In this review, we consider the role these cellular mechanisms play in the development of IR. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
