التفاصيل البيبلوغرافية
| العنوان: |
Continuous fat oxidation in acetyl—CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity. |
| المؤلفون: |
Cheol Soo Choi, Savage, David B., Abu-Elheiga, Lutfi, Zhen-Xiang Liu, Sheene Kim, Kulkami, Ameya, Distefano, Alberto, Yu-Jin Hwang, Reznick, Richard M., Codella, Roberto, Dongyan Zhang, Cline, Gary W., Wakil, Salih J., Shulman, Gerald I. |
| المصدر: |
Proceedings of the National Academy of Sciences of the United States of America; 10/16/2007, Vol. 104 Issue 42, p16480-16485, 6p, 2 Charts, 4 Graphs |
| مصطلحات موضوعية: |
ENERGY metabolism, CALORIC expenditure, TYPE 2 diabetes, INSULIN, BODY mass index, MICE |
| مستخلص: |
Acetyl—CoA carboxylase 2 (ACC)2 is a key regulator of mitochondrial fat oxidation. To examine the impact of ACC2 deletion on whole—body energy metabolism, we measured changes in substrate oxidation and total energy expenditure in Acc2-/- and WT control mice fed either regular or high-fat diets. To determine insulin action in vivo, we also measured whole-body insulin-stimulated liver and muscle glucose metabolism during a hyperinsulinemic—euglycemic clamp in Acc2-/- and WT control mice fed a high-fat diet. Contrary to previous studies that have suggested that increased fat oxidation might result in lower glucose oxidation, both fat and carbohydrate oxidation were simultaneously increased in Acc2-/- mice. This increase in both fat and carbohydrate oxidation resulted in an increase in total energy expenditure, reductions in fat and lean body mass and prevention from diet-induced obesity. Furthermore, Acc2-/- mice were protected from fat-induced peripheral and hepatic insulin resistance. These improvements in insulin-stimulated glucose metabolism were associated with reduced diacylglycerol content in muscle and liver, decreased PKCθ activity in muscle and PKCϵ activity in liver, and increased insulin-stimulated Akt2 activity in these tissues. Taken together with previous work demonstrating that Acc2-/- mice have a normal lifespan, these data suggest that Acc2 inhibition is a viable therapeutic option for the treatment of obesity and type 2 diabetes. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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