دورية أكاديمية
Young Children Have Higher Variability of Insulin Requirements: Observations During Hybrid Closed-Loop Insulin Delivery.
| العنوان: | Young Children Have Higher Variability of Insulin Requirements: Observations During Hybrid Closed-Loop Insulin Delivery. |
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| المؤلفون: | Dovc, Klemen, Boughton, Charlotte, Tauschmann, Martin, Thabit, Hood, Bally, Lia, Allen, Janet M, Acerini, Carlo L, Arnolds, Sabine, de Beaufort, Carine, Bergenstal, Richard M, Campbell, Fiona, Criego, Amy, Dunger, David B, Elleri, Daniella, Evans, Mark L, Fröhlich-Reiterer, Elke, Hofer, Sabine, Kapellen, Thomas, Leelarathna, Lalantha, Pieber, Thomas R, Rami-Merhar, Birgit, Shah, Viral N, Sibayan, Judy, Wilinska, Malgorzata E, Hovorka, Roman, APCam11, AP@Home, and KidsAP Consortia |
| بيانات النشر: | American Diabetes Association //dx.doi.org/10.2337/dc18-2625 Diabetes Care |
| سنة النشر: | 2019 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | Adolescent, Adult, Age Factors, Aged, Blood Glucose, Blood Glucose Self-Monitoring, Child, Preschool, Cross-Over Studies, Diabetes Mellitus, Type 1, Dose-Response Relationship, Drug, Female, Humans, Hypoglycemic Agents, Individuality, Infant, Insulin, Insulin Infusion Systems, Male, Middle Aged, Multicenter Studies as Topic, Randomized Controlled Trials as Topic, Retrospective Studies, Young Adult |
| الوصف: | OBJECTIVE: To quantify age-related variability of insulin needs during day and night closed-loop insulin delivery. RESEARCH DESIGN AND METHODS: We retrospectively analyzed data from hybrid closed-loop studies involving young children (1-6 years old, n = 20), children (7-12 years, n = 21), adolescents (13-17 years, n = 15), and adults (>18 years, n = 58) with type 1 diabetes. The coefficient of variation quantified variability of insulin needs during 3 weeks of unrestricted-living hybrid closed-loop use. RESULTS: Data from 2,365 nights and 2,367 days in 114 participants were analyzed. The coefficient of variation of insulin delivery was higher in young children compared with adults (mean difference at nighttime 10.7 percentage points [95% CI 2.9-18.4], P = 0.003; daytime 6.4 percentage points [95% CI 2.0-10.9], P = 0.002) and compared with adolescents (mean difference at nighttime 10.2 percentage points [95% CI 0.0-20.4], P = 0.049; daytime 7.0 percentage points [95% CI 1.1-12.8], P = 0.014). CONCLUSIONS: Diabetes management in young children is complicated by higher variability in insulin requirements, supporting fast-track clinical practice adoption of closed-loop in this vulnerable population. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | Print-Electronic; application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/292141Test |
| DOI: | 10.17863/CAM.39293 |
| الإتاحة: | https://doi.org/10.17863/CAM.39293Test https://www.repository.cam.ac.uk/handle/1810/292141Test |
| حقوق: | All rights reserved |
| رقم الانضمام: | edsbas.A5D55F93 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.39293 |
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