دورية أكاديمية
Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients
| العنوان: | Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients |
|---|---|
| المؤلفون: | Nielsen, Roni, Møller, Niels, Gormsen, Lars C, Tolbod, Lars Poulsen, Hansson, Nils Henrik, Sorensen, Jens, Harms, Hendrik Johannes, Frøkiær, Jørgen, Eiskjaer, Hans, Jespersen, Nichlas Riise, Mellemkjaer, Søren, Lassen, Thomas Ravn, Pryds, Kasper, Bøtker, Hans Erik, Wiggers, Henrik |
| المصدر: | Nielsen , R , Møller , N , Gormsen , L C , Tolbod , L P , Hansson , N H , Sorensen , J , Harms , H J , Frøkiær , J , Eiskjaer , H , Jespersen , N R , Mellemkjaer , S , Lassen , T R , Pryds , K , Bøtker , H E & Wiggers , H 2019 , ' Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients ' , Circulation , vol. 139 , no. 18 , pp. 2129-2141 . https://doi.org/10.1161/CIRCULATIONAHA.118.036459Test |
| سنة النشر: | 2019 |
| المجموعة: | Aarhus University: Research |
| مصطلحات موضوعية: | 3-hydroxybutyrate, BLOOD-FLOW, BODIES, EFFICIENCY, FAILING HEART, FATTY-ACID UPTAKE, IDIOPATHIC DILATED CARDIOMYOPATHY, INFUSION, INSULIN, METABOLISM, SKELETAL-MUSCLE, echocardiography, heart failure, ketone bodies, positron-emission tomography |
| الوصف: | Background: Myocardial utilization of 3-hydroxybutyrate (3-OHB) is increased in patients with heart failure and reduced ejection fraction (HFrEF). However, the cardiovascular effects of increased circulating plasma-3-OHB levels in these patients are unknown. Consequently, the authors' aim was to modulate circulating 3-OHB levels in HFrEF patients and evaluate: (1) changes in cardiac output (CO); (2) a potential dose-response relationship between 3-OHB levels and CO; (3) the impact on myocardial external energy efficiency (MEE) and oxygen consumption (MVO 2 ); and (4) whether the cardiovascular response differed between HFrEF patients and age-matched volunteers. Methods: Study 1: 16 chronic HFrEF patients (left ventricular ejection fraction: 37±3%) were randomized in a crossover design to 3-hour of 3-OHB or placebo infusion. Patients were monitored invasively with a Swan-Ganz catheter and with echocardiography. Study 2: In a dose-response study, 8 HFrEF patients were examined at increasing 3-OHB infusion rates. Study 3 to 4: 10 HFrEF patients and 10 age-matched volunteers were randomized in a crossover design to 3-hour 3-OHB or placebo infusion. MEE and MVO 2 were evaluated using 11C-acetate positron emission tomography. Results: 3-OHB infusion increased circulating levels of plasma 3-OHB from 0.4±0.3 to 3.3±0.4 mM (P<0.001). CO rose by 2.0±0.2 L/min (P<0.001) because of an increase in stroke volume of 20±2 mL (P<0.001) and heart rate of 7±2 beats per minute (bpm) (P<0.001). Left ventricular ejection fraction increased 8±1% (P<0.001) numerically. There was a dose-response relationship with a significant CO increase of 0.3 L/min already at plasma-3-OHB levels of 0.7 mM (P<0.001). 3-OHB increased MVO 2 without altering MEE. The response to 3-OHB infusion in terms of MEE and CO did not differ between HFrEF patents and age-matched volunteers. Conclusions: 3-OHB has beneficial hemodynamic effects in HFrEF patients without impairing MEE. These beneficial effects are detectable in the physiological ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://pure.au.dk/portal/en/publications/39ece02a-c4b0-468a-838f-523d7c6ce906Test |
| DOI: | 10.1161/CIRCULATIONAHA.118.036459 |
| الإتاحة: | https://doi.org/10.1161/CIRCULATIONAHA.118.036459Test https://pure.au.dk/portal/en/publications/39ece02a-c4b0-468a-838f-523d7c6ce906Test https://pure.au.dk/ws/files/198445417/CIRCULATIONAHA.118.036459.pdfTest http://www.scopus.com/inward/record.url?scp=85065508209&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.924C44FF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1161/CIRCULATIONAHA.118.036459 |
|---|