دورية أكاديمية
Diverse Streptococcus pneumoniae strains drive a MAIT cell response through MR1-dependent and cytokine-driven pathways
| العنوان: | Diverse Streptococcus pneumoniae strains drive a MAIT cell response through MR1-dependent and cytokine-driven pathways |
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| المؤلفون: | Kurioka, A, Van Wilgenburg, B, Javan, RR, Hoyle, R, Van Tonder, AJ, Harrold, CL, Leng, T, Howson, LJ, Shepherd, D, Cerundolo, V, Brueggemann, AB, Klenerman, P |
| المساهمون: | Wellcome Trust, John Fell Fund, University of Oxford |
| المصدر: | 999 ; 988 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2017 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Immunology, Infectious Diseases, Microbiology, MAIT cells, pneumococcus, riboflavin, innate, macrophages, cytokines, MR1, T cells, BACTERIAL-INFECTION, DENDRITIC CELLS, DIFFERENTIATION, ACTIVATION, EXPRESSION, SEROTYPES, INFLUENZA, DISEASE, 11 Medical And Health Sciences, 06 Biological Sciences |
| جغرافية الموضوع: | United States |
| الوصف: | Mucosal Associated Invariant T (MAIT) cells represent an innate T-cell population which can recognize ligands generated by the microbial riboflavin synthesis pathway, presented via the major-histocompatibility-complex (MHC) class I-related molecule MR1. Streptococcus pneumoniae (the 'pneumococcus') is a major human pathogen that is also associated with commensal carriage, thus host control at the mucosal interface is critical. The recognition of pneumococci by MAIT cells has not been defined, nor have the genomics and transcriptomics of the riboflavin operon. We observed robust recognition of pneumococci by MAIT cells, using both MR1-dependent and independent pathways. The pathway used was dependent on the antigen-presenting cell. The riboflavin operon was highly conserved across a range of 571 pneumococci from 39 countries dating back to 1916, and different versions of the riboflavin operon were also identified in related Streptococcus species. These data indicate an important functional relationship between MAIT cells and pneumococci. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0022-1899 |
| العلاقة: | Journal of Infectious Diseases; http://hdl.handle.net/10044/1/57075Test; https://dx.doi.org/10.1093/infdis/jix647Test; 04992/Z/14/Z; 083511/Z/07/Z |
| DOI: | 10.1093/infdis/jix647 |
| الإتاحة: | https://doi.org/10.1093/infdis/jix647Test http://hdl.handle.net/10044/1/57075Test |
| حقوق: | © The Author(s) 2017. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0Test/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| رقم الانضمام: | edsbas.738C93F7 |
| قاعدة البيانات: | BASE |
| تدمد: | 00221899 |
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| DOI: | 10.1093/infdis/jix647 |