دورية أكاديمية
Atg5 regulates late endosome and lysosome biogenesis
| العنوان: | Atg5 regulates late endosome and lysosome biogenesis |
|---|---|
| المؤلفون: | Peng JunYa, Zhang Ran, Cui YiTong, Liu HaoDong, Zhao XiaoXin, Huang Lei, Hu MingXu, Yuan XiaoXi, Ma BenYu, Ma XiaoWei, Takashi, Ueno, Masaaki, Komatsu, Liang XingJie, Yu Li |
| المساهمون: | Yu, L (reprint author), Tsinghua Univ, Sch Life Sci, Tsinghua Univ Peking Univ Joint Ctr Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100084, Peoples R China., Tsinghua Univ, Sch Life Sci, Tsinghua Univ Peking Univ Joint Ctr Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100084, Peoples R China., Tsinghua Univ, Sch Life Sci, Cell Biol Core Facil, Beijing 100084, Peoples R China., Tsinghua Univ, Dept Math Sci, Beijing 100084, Peoples R China., Tsinghua Univ, Sch Life Sci, Tsinghua Univ Peking Univ Joint Ctr Life Sci, Beijing 100084, Peoples R China., Natl Ctr Nanosci & Technol, Div Nanomed & Nanobiol, Lab Nanomed & Nanosafety, Beijing, Peoples R China., Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China., Juntendo Univ, Sch Med, Dept Biochem, Bunkyo Ku, Tokyo 1138421, Japan., Tokyo Metropolitan Inst Med Sci, Prot Metab Project, Tokyo 1568506, Japan. |
| المصدر: | SCI ; PubMed |
| بيانات النشر: | science china life sciences |
| سنة النشر: | 2014 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | endosome/lysosome biogenesis, atg5, autophagy, CHEDIAK-HIGASHI-SYNDROME, VACUOLAR H+-ATPASE, MULTIVESICULAR ENDOSOMES, TRAFFICKING, FUSION, CELLS, INFLAMMATION, IMMUNITY, PATHWAY |
| الوصف: | Autophagy is an evolutionarily conserved lysosome-based degradation process. Atg5 plays a very important role in autophagosome formation. Here we show that Atg5 is required for biogenesis of late endosomes and lysosomes in an autophagy-independent manner. In Atg5 (-/-) cells, but not in other essential autophagy genes defecting cells, recycling and retrieval of late endosomal components from hybrid organelles are impaired, causing persistent hybrid organelles and defective formation of late endosomes and lysosomes. Defective retrieval of late endosomal components from hybrid organelles resulting from impaired recruitment of a component of V1-ATPase to acidic organelles blocks the pH-dependent retrieval of late endosomal components from hybrid organelles. Lowering the intracellular pH restores late endosome/lysosome biogenesis in Atg5 (-/-) cells. Our data demonstrate an unexpected role of Atg5 and shed new light on late endosome and lysosome biogenesis. ; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000329624500008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Test ; Biology ; SCI(E) ; PubMed ; 6 ; ARTICLE ; liyulab@mail.tsinghua.edu.cn ; 1,SI ; 59-68 ; 57 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| ردمك: | 978-0-00-329624-2 0-00-329624-5 |
| تدمد: | 1674-7305 1869-1889 |
| العلاقة: | SCIENCE CHINA-LIFE SCIENCES.2014,57,(1,SI),59-68.; 655238; http://hdl.handle.net/20.500.11897/190057Test; WOS:000329624500008 |
| DOI: | 10.1007/s11427-013-4588-8 |
| الإتاحة: | https://doi.org/20.500.11897/190057Test https://doi.org/10.1007/s11427-013-4588-8Test https://hdl.handle.net/20.500.11897/190057Test |
| رقم الانضمام: | edsbas.52BFD2CF |
| قاعدة البيانات: | BASE |
| ردمك: | 9780003296242 0003296245 |
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| تدمد: | 16747305 18691889 |
| DOI: | 10.1007/s11427-013-4588-8 |