التفاصيل البيبلوغرافية
| العنوان: |
Therapeutic Vaccination of HIV-1-Infected Patients on Haart with a Recombinant HIV-1 Nef -Expressing Mva: Safety, Immunogenicity and Influence on Viral Load during Treatment Interruption |
| المؤلفون: |
Harrer, Ellen, Bäuerle, Michael, Ferstl, Barbara, Chaplin, Paul, Petzold, Barbara, Mateo, Luis, Handley, Amanda, Tzatzaris, Maria, Vollmar, Jens, Bergmann, Silke, Rittmaier, Marion, Eismann, Kathrin, Müller, Sandra, Kalden, Joachim R, Spriewald, Bernd, Willbold, Dieter, Harrer, Thomas |
| المصدر: |
Antiviral Therapy ; volume 10, issue 2, page 285-300 ; ISSN 1359-6535 2040-2058 |
| بيانات النشر: |
SAGE Publications |
| سنة النشر: |
2005 |
| مصطلحات موضوعية: |
Infectious Diseases, Pharmacology (medical), Pharmacology |
| الوصف: |
The safety and immunogenicity of an HIV-1 nef-expressing modified vaccinia virus Ankara (MVA) was investigated in 14 HIV-1-positive patients (CD4 >400/μl) on highly active antiretroviral therapy (HAART). Patients were vaccinated at weeks 0, 4 and 16, followed by interruption of HAART at week 18. MVA- nef was well-tolerated except for local reactions, with only mild systemic side effects reported in a few patients. Vaccination with MVA- nef was associated with recognition of new HIV-1 T-cell epitopes (cytotoxic T-lymphocyte epitopes in 9/14 patients, CD4 epitope/recombinant Nef protein in 2/14) and an increase in CD4+ and CD8+ T cells. All patients had been vaccinated against smallpox and a strong T-cell and antibody response to MVA was induced in all patients. After interruption of HAART, viral load rebounded in all patients, but after a median time of 36 (4–76) weeks in 9/14 patients, viraemia remained below the pre-HAART viral load and CD4 counts stayed above the pre-HAART levels. While six patients have remained off therapy for a median time of 64 (57–76) weeks, HAART was resumed in 8/14 patients after a median treatment interruption time of 15 (4–38) weeks. This study has demonstrated that MVA- nef is safe and immunogenic in HIV-1-infected subjects and has provided encouraging data on the potential of therapeutic vaccinations. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1177/135965350501000212 |
| الإتاحة: |
https://doi.org/10.1177/135965350501000212Test |
| حقوق: |
http://journals.sagepub.com/page/policies/text-and-data-mining-licenseTest |
| رقم الانضمام: |
edsbas.96C50F35 |
| قاعدة البيانات: |
BASE |
