Promoting HIV indicator condition-guided testing in hospital settings (PROTEST 2.0): study protocol for a multicentre interventional study
| العنوان: | Promoting HIV indicator condition-guided testing in hospital settings (PROTEST 2.0): study protocol for a multicentre interventional study |
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| المؤلفون: | Bogers, Saskia J., Schim van der Loeff, Maarten F., Davidovich, Udi, Boyd, Anders, van der Valk, Marc, Brinkman, Kees, de Bree, Godelieve J., Reiss, Peter, van Bergen, Jan E. A. M., Geerlings, Suzanne E., van Bergen, J. E. A. M., Brokx, P., Deug, F., Heidenrijk, M., Prins, M., Reiss, P., van der Valk, M., de Bree, G. J., Geerlings, S. E., Hoornenborg, E., Achterbergh, R. C. A., Ananworanich, J., van de Beek, D., Brinkman, N., de Bruin, M., Bruisten, S., Coyer, L., Dijkstra, M., Geijtenbeek, T. B. H., Godfried, M. H., Goorhuis, A., Hankins, C. A., Hogewoning, A., Hovius, J. W., de Jong, K., Kootstra, N. A., Lauw, F., van der Meer, J. T., Mulder, B. J., Nellen, F. J., Peters, E., van der Poll, T., van Rooijen, M. S., Sonder, G. J., de Vries, H. J., van Vugt, M., Wiersinga, W. J., Wit, F. W., Zantkuijl, P. |
| المساهمون: | Graduate School, Vascular Medicine, AII - Infectious diseases, Infectious diseases, APH - Aging & Later Life, APH - Global Health, Global Health, General practice, APH - Methodology, APH - Quality of Care, Medical Microbiology and Infection Prevention, Neurology, Amsterdam Neuroscience - Neuroinfection & -inflammation, Experimental Immunology, Center of Experimental and Molecular Medicine, Dermatology, APH - Digital Health, APH - Personalized Medicine, Sociale Psychologie (Psychologie, FMG), Psychology Other Research (FMG), Stichting Aidsfonds, Virology, Medical Microbiology & Infectious Diseases, Internal Medicine |
| المصدر: | BMC Infectious Diseases, 21, 1 BMC Infectious Diseases BMC infectious diseases, 21(1):519. BioMed Central BMC Infectious Diseases, 21:519. BioMed Central BMC Infectious Diseases, 21(1):519, 1-9. BioMed Central Ltd. BMC Infectious Diseases, 21 BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-9 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Pediatrics, Tuberculosis, Multifaceted intervention, HIV Positivity, HIV Transmission Elimination AMsterdam (H-TEAM) Consortium, HIV Infections, Infectious and parasitic diseases, RC109-216, Indicator condition, Healthcare quality improvement, Microbiology, 03 medical and health sciences, Study Protocol, 0302 clinical medicine, Medical microbiology, SDG 3 - Good Health and Well-being, 1108 Medical Microbiology, Intervention (counseling), medicine, Clinical endpoint, Prevalence, Humans, Mass Screening, 030212 general & internal medicine, Netherlands, 030505 public health, business.industry, Patient Selection, virus diseases, 1103 Clinical Sciences, Hepatitis B, Vulvar cancer, medicine.disease, Hospitals, HIV testing, Infectious Diseases, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], Implementation, Tropical medicine, 0305 other medical science, business, 0605 Microbiology |
| الوصف: | Background Late presentation remains a key barrier towards controlling the HIV epidemic. Indicator conditions (ICs) are those that are AIDS-defining, associated with a prevalence of undiagnosed HIV > 0.1%, or whose clinical management would be impeded if an HIV infection were undiagnosed. IC-guided HIV testing is an effective strategy in identifying undiagnosed HIV, but opportunities for earlier HIV diagnosis through IC-guided testing are being missed. We present a protocol for an interventional study to improve awareness of IC-guided testing and increase HIV testing in patients presenting with ICs in a hospital setting. Methods We designed a multicentre interventional study to be implemented at five hospitals in the region of Amsterdam, the Netherlands. Seven ICs were selected for which HIV test ratios (proportion of patients with an IC tested for HIV) will be measured: tuberculosis, cervical/vulvar cancer or high-grade cervical/vulvar dysplasia, malignant lymphoma, hepatitis B and C, and peripheral neuropathy. Prior to the intervention, a baseline assessment of HIV test ratios across ICs will be performed in eligible patients (IC diagnosed January 2015 through May 2020, ≥18 years, not known HIV positive) and an assessment of barriers and facilitators for HIV testing amongst relevant specialties will be conducted using qualitative (interviews) and quantitative methods (questionnaires). The intervention phase will consist of an educational intervention, including presentation of baseline results as competitive graphical audit and feedback combined with discussion on implementation and opportunities for improvement. The effect of the intervention will be assessed by comparing HIV test ratios of the pre-intervention and post-intervention periods. The primary endpoint is the HIV test ratio within ±3 months of IC diagnosis. Secondary endpoints are the HIV test ratio within ±6 months of diagnosis, ratio ever tested for HIV, HIV positivity percentage, proportion of late presenters and proportion with known HIV status prior to initiating treatment for their IC. Discussion This protocol presents a strategy aimed at increasing awareness of the benefits of IC-guided testing and increasing HIV testing in patients presenting with ICs in hospital settings to identify undiagnosed HIV in Amsterdam, the Netherlands. Trial registration Dutch trial registry: NL7521. Registered 14 February 2019. |
| وصف الملف: | application/pdf |
| تدمد: | 1471-2334 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e83d0f0c47b5e3516c9bc5d8730a6e76Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e83d0f0c47b5e3516c9bc5d8730a6e76 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712334 |
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