المؤلفون: Bikramjit, Das, Venkataseshan, Sundaram, William, Tarnow-Mordi, Alpana, Ghadge, Lakhbir Kaur, Dhaliwal, Praveen, Kumar

المصدر: Journal of perinatology : official journal of the California Perinatal Association. 38(5)

مصطلحات موضوعية: Male, Time Factors, Anthropometry, Placenta, Infant, Newborn, India, Infant, Gestational Age, Constriction, Umbilical Cord, Neurodevelopmental Disorders, Pregnancy, Child, Preschool, Humans, Blood Transfusion, Female, Infant, Premature

الوصف: To compare effect of placental transfusion by delayed cord clamping (DCC) or cord milking (CM) with early cord clamping (ECC) on a composite of mortality or abnormal neurological status at 40 weeks' post-menstrual age (PMA) and 24-30 months' chronological age in neonates of 30-33 weeks' gestation.Randomized, controlled trial.A composite of mortality or abnormal neurological status at 40 weeks PMA and survival free of neurodevelopmental abnormalities at 24-30 months' chronological age.A total of 461 neonates were randomized to placental transfusion (n = 233) or to ECC (n = 228). Among those assigned to placental transfusion group, 173 underwent DCC while in the remaining 60, CM was done. Incidence of mortality or abnormal neurological status at 40 weeks PMA (43 (18%) vs 35 (15%), RR (95% CI) 1.2 (0.8, 1.8), p = 0.4) and survival free of neurodevelopmental impairment at 24-30 months of chronological age (99 (47%) vs. 100 (50%); RR (95% CI): 0.9 (0.8, 1.2); P = 0.9) was similar between the study groups. The placental transfusion group showed a trend towards lower incidence of necrotizing enterocolitis.In 30-33 weeks' gestation preterm neonates, placental transfusion as compared to early cord clamping resulted in similar mortality or abnormal neurological status at 40 weeks PMA and at 24-30 months of chronological age.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::31c314f8c8e4940cda229d06f0dc9d97Test
https://pubmed.ncbi.nlm.nih.gov/29410545Test

المؤلفون: Bikramjit Das, Venkataseshan Sundaram, Lakhbir Kaur Dhaliwal, Praveen Kumar, William Tarnow Mordi, Reena Das

المصدر: Indian journal of pediatrics. 85(3)

مصطلحات موضوعية: Male, medicine.medical_specialty, Cord, Blood transfusion, Anemia, medicine.medical_treatment, Iron, Placenta, India, Gastroenterology, Umbilical cord, Umbilical Cord, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, 030225 pediatrics, Internal medicine, medicine, Humans, Blood Transfusion, 030212 general & internal medicine, Longitudinal Studies, Child, Randomized Controlled Trials as Topic, biology, business.industry, Cesarean Section, Infant, Newborn, Infant, medicine.disease, Constriction, Ferritin, medicine.anatomical_structure, Spain, Pediatrics, Perinatology and Child Health, biology.protein, Gestation, Female, business, Infant, Premature

الوصف: To assess the effect of placental transfusion by delayed cord clamping (DCC) of 60 s or cord milking (CM) on serum ferritin levels at hospital discharge and 3 mo of postmenstrual age (PMA) in preterm neonates of 30 to 33 wk gestation in comparison to early cord clamping (ECC) within 10 s. This mixed longitudinal study was conducted in moderately preterm neonates of 30 to 33 wk gestation born in a level III unit in Northern India with the study sample nested within a randomized controlled trial on placental transfusion. Intervention was delayed cord clamping for 60 s or cord milking compared with early cord clamping (within 10 s). Primary outcome measure was serum ferritin levels at discharge. Secondary outcome measures were serum ferritin levels at 3 mo PMA, incidence of anemia, need for blood transfusion and incidence of iron deficiency by 3 mo PMA. Out of the 215 randomly chosen infants, serum ferritin levels were estimated at least at one time point (at discharge or at 3 mo PMA) in 197 neonates [placental transfusion – 107; early cord clamping – 90]. Amongst them, ferritin level was estimated at discharge in 141 neonates, at 3 mo PMA in 76 neonates and at both time points in 20 neonates. Median (IQR) serum ferritin (μg/L) at discharge was significantly higher in placental transfusion group in comparison to the ECC group [399 (309,600) (n = 79) vs. 254 (190,311) (n = 62); p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8468cebe6917fa63e55f4c2700d2a5Test
https://pubmed.ncbi.nlm.nih.gov/29680986Test

المؤلفون: Neelam Aggarwal, G. R. V. Prasad, V. Chopra, Rashmi Bagga, Subhas Chandra Saha, Lakhbir Kaur Dhaliwal

المصدر: Hypertension in Pregnancy. 26:139-149

مصطلحات موضوعية: Adult, Research design, medicine.medical_specialty, Referral, Pregnancy Complications, Cardiovascular, India, Gestational Age, Severity of Illness Index, Pregnancy, Severity of illness, Internal Medicine, Humans, Medicine, Adverse effect, Developing Countries, Retrospective Studies, Eclampsia, business.industry, Obstetrics, Pregnancy Outcome, Obstetrics and Gynecology, Gestational age, Retrospective cohort study, medicine.disease, Research Design, Chronic Disease, Hypertension, Female, business, Follow-Up Studies

الوصف: To assess pregnancy outcome in patients with severe chronic hypertension.A retrospective analysis of a 10-year period (1995-2004) in a referral hospital in northern India. The outcome was compared with those women with mild chronic hypertension who registered in the hypertensive disorders with pregnancy clinic immediately before and after each woman with severe chronic hypertension.Hospital data identified 25 such women. Superimposed preeclampsia (36.4% versus 8%), preterm delivery (86.4% versus 42%), and perinatal mortality (27.2% versus none) were increased in patients with severe chronic hypertension as compared to those with mild hypertension.The small number of cases reflects the lack of antenatal supervision in developing countries. A much larger number of women are referred in the third trimester with eclampsia or severe preeclampsia, at which time it is not possible to identify whether or not they had underlying hypertension. Adverse events were found to occur more often in patients with severe chronic hypertension compared with those with mild hypertension.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ed3b4531373e860fd1a41754185548Test
https://doi.org/10.1080/10641950701204588Test

المؤلفون: L. Maithi, Hari Shankar, Lakhbir Kaur Dhaliwal, Rajat Sandhir, Alka Kriplani, Shobha Kandpal, Vijay Laxmi Jindal, Nomita Chandhiok, Rohini Sehgal, Ajay Kumar, Santosh Kurra, D.N. Rao, Neeta Kumar

المصدر: Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. 35(3)

مصطلحات موضوعية: North indian population, Pregnancy, 2nd trimester, business.industry, Pregnancy Complications, Hematologic, Albumin, Obstetrics and Gynecology, Physiology, Hemodynamics, India, Anemia, Gravidity, medicine.disease, Body weight, Nap, Young Adult, Reference Values, Pregnancy Trimester, Second, Immunology, medicine, Alkaline phosphatase, Humans, Female, business

الوصف: Pregnancy is accompanied by several haemodynamic, biochemical and haematological changes, which may lead to severe problems, if they are not suitably addressed. The current study highlights the haematological and biochemical differences observed in anaemic (AP) and non-anaemic primigravida (NAP), in the 2nd trimester, in a north Indian population. There were significant differences (p0.05) in the body weight and body temperature of NAP compared with AP. A significant decrease (p0.001) in haematological parameters including haemoglobin, haematocrit, erythrocyte count, MCH and MCHC, was observed in AP; however, MCV was found to be significantly higher (p = 0.038). Many biochemical parameters viz. potassium, albumin, total protein and calcium levels were significantly reduced (p0.01) in AP, except alkaline phosphatase whose level was found significantly increased (p0.01). The findings of the study suggest that haematological and biochemical changes take place in anaemia during pregnancy. Further, the results obtained should be used for establishing normative values for similar populations.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d72d855564c79018d8192c0452aee1Test
https://pubmed.ncbi.nlm.nih.gov/25153118Test

المؤلفون: Subhas Chandra Saha, Rashmi Bagga, Neelam Choudhary, Ainharan Raveendran, Lakhbir Kaur Dhaliwal

المصدر: The European journal of contraceptionreproductive health care : the official journal of the European Society of Contraception. 16(5)

مصطلحات موضوعية: Adult, medicine.medical_specialty, medicine.medical_treatment, India, Abortion, Dinoprost, Cicatrix, Uterine Rupture, Pregnancy, medicine, Humans, Pharmacology (medical), Caesarean section, Hysterotomy, Misoprostol, Developing Countries, Retrospective Studies, Gynecology, Uterine Diseases, Abortifacient Agents, Nonsteroidal, Obstetrics, business.industry, Obstetrics and Gynecology, Abortion, Induced, Mifepristone, medicine.disease, Uterine rupture, Reproductive Medicine, Case-Control Studies, Pregnancy Trimester, Second, Gestation, Female, business, medicine.drug

الوصف: To study the safety of second trimester abortion in women with previous uterine scar.We screened the records of 518 women who underwent an abortion between 12 and 20 weeks' gestation at the Postgraduate Institute of Medical Education and Research, Chandigarh, India, from January 2000 to December 2010. Methods used for abortion were: (i) vaginal misoprostol with or without pre-treatment with mifepristone, and (ii) intracervical dinoprostol gel or vaginal misoprostol ± extra-amniotic saline ± oxytocin infusion. Seventeen women, aborted by means of a hysterotomy, were excluded from further analysis.Of the remaining 501 women, 44 had a uterine scar (Group 1) and 457 had none (Group 2). In Group 1, 40/44 (91%) and in Group 2, 452/457 (99%) women aborted successfully. The mean induction-abortion interval (IAI) was similar in the two groups (15.03 ± 10.69 hours and 12.52 ± 9.0 hours in Groups 1 and 2, respectively; p = 0.083). There were three uterine ruptures, 1/44 (2%) in group 1 and 2/457 (0.4%) in group 2 (p = 0.132, NS); all three women had received mifepristone followed by vaginal misoprostol.In women with a scarred uterus, midtrimester abortion may be successfully achieved using any of the aforementioned regimens.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a7781654560170a2c18c6afe4f2bdbTest
https://pubmed.ncbi.nlm.nih.gov/21929363Test

المؤلفون: Ainharan Raveendran, Seema Chopra, Lakhbir Kaur Dhaliwal, Minakshi Rohilla

المصدر: Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. 30(7)

مصطلحات موضوعية: Adult, medicine.medical_specialty, Pediatrics, Adolescent, Anemia, Iron, India, Severity of Illness Index, Hemoglobins, Young Adult, Predictive Value of Tests, Pregnancy, Epidemiology, Severity of illness, medicine, Fetal distress, Prevalence, Humans, Young adult, Academic Medical Centers, Obstetrics, business.industry, Postpartum Hemorrhage, Pregnancy Complications, Hematologic, Obstetrics and Gynecology, Stillbirth, medicine.disease, Small for gestational age, Female, Morbidity, business, Premature rupture of membranes

الوصف: Anaemia is a major health problem among woman of reproductive age group, particularly in developing countries. We undertook this study to determine the maternal and perinatal outcome in patients with severe anaemia in pregnancy, with a haemoglobin concentration of < 7 g/dl. The in-hospital data were analysed for 12 months between January 2007 and December 2007 and 2.15% (n = 96) of women were found to have severe anaemia. Out of these, 18.75% had pre-term premature rupture of membranes and 5.12% of all deliveries were pre-term. Hypertensive diseases of pregnancy were seen in 17.7%; abruption in 3.12% and 9.37% had congestive cardiac failure. Postpartum haemorrhage was seen in 25.5% of the patients and 8.33% had puerperal pyrexia. Fetal distress was seen in 26% of and 33.33% had small for gestational age neonates; there were 16.66% stillbirths and 4.16% neonatal deaths. Of the 96 severely anaemic women, six died after admission. Our study shows that efforts must be taken towards safe motherhood and spreading awareness about the various consequences of anaemia, which is usually preventable with early correction.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79af424b2e6ad6e9161a94aa61bf635Test
https://pubmed.ncbi.nlm.nih.gov/21823875Test

المؤلفون: Pooja Sikka, Arun Kalpdev, Seema Chopra, Lakhbir Kaur Dhaliwal, Vanita Jain

المصدر: Archives of gynecology and obstetrics. 283(5)

مصطلحات موضوعية: medicine.medical_specialty, Decapitation, Developing country, India, Tertiary care, Pregnancy, medicine, Childbirth, Humans, Obstructed labor, Fetal Death, Retrospective Studies, Academic Medical Centers, Obstetrics, business.industry, Obstetrics and Gynecology, Retrospective cohort study, General Medicine, medicine.disease, Destructive procedure, Obstetric Labor Complications, Fetal Diseases, Female, business, Developed country, Craniotomy, Hydrocephalus

الوصف: Destructive operations have a limited role in modern day obstetrics. In the developed countries, obstetrics has become so advanced that these instruments have actually been put away. However, in developing countries like India, these procedures have a limited role where obstructed labor still continues to plague thousands of women every year and accounts for 8% of maternal deaths. This study was planned to define the changing role of destructive operations in obstetrics over the years as more number of abdominal deliveries are conducted in modern day obstetrics than these procedures. A retrospective analysis of destructive operations performed at the Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India, over a span of 25 years, between 1983 and 2007, was carried out. Of a total of 85,952 deliveries in PGIMER in these 25 years, there were 25,474 cesarean deliveries (29.63%), and 8,826 (10.26%) operative vaginal deliveries. The total number of destructive operations performed was 230 (0.26%). There were 202 craniotomies (87.8%), 13 decapitations (5.7%), 8 eviscerations (3.6%) and 7 cleidotomies (2.9%). There should be an individualized approach to each case of obstructed labor. The health care provider has to decide on the options available to him to deliver the mother by the safest route without causing morbidity and mortality. If the fetus is dead, a destructive procedure can be considered in place of abdominal-route delivery which carries considerable risk to the debilitated mother in neglected labor.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f8af64eb5052bbcf8e3f3be9bf54965Test
https://pubmed.ncbi.nlm.nih.gov/21193917Test

المؤلفون: Lakhbir Kaur Dhaliwal, Seema Chopra

المصدر: Archives of gynecology and obstetrics. 281(2)

مصطلحات موضوعية: Economic growth, Urban Population, Research methodology, medicine.medical_treatment, Population, Fertility regulation, Developing country, India, North india, Environmental health, Surveys and Questionnaires, medicine, Humans, Emergency contraception, education, Contraception Behavior, education.field_of_study, business.industry, Obstetrics and Gynecology, General Medicine, Contraception, Cross-Sectional Studies, Family planning, Family Planning Services, Female, business, Population policy

الوصف: Despite the provision of safe and affordable family planning services, 120 million couples worldwide are not using any contraception to limit or space their family, and many who use one or the other method, conceive. According to the National Population Policy (NPP) 2000, various methods of contraception and fertility regulation shall be made accessible to all, so that India's population in 2010 will be 1,107 million instead of 1,162 million.A hospital-based cross-sectional survey conducted in 2006. In-person interviews carried out with attendees of Gynaecology and Obstetrics outpatient clinics, and indoor patients of three hospitals of urban population to collect data regarding knowledge, attitude and practices of family planning methods.A total of 55.2% subjects were aware of contraceptive methods, mostly barrier (52.7%), IUCD (46.1%) and oral pills (43.2%), but only 31.7% had ever used barrier contraception, IUCD 10.3% and oral pills 3.3%. Permanent methods were known to nearly 50% subjects but acceptance was very less, 5% only. Emergency contraception was known to 13.8% subjects.Majority of women have favorable attitude towards family planning, but use of long-acting new methods is still low in our population, which needs to be promoted.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec2b184a2f082c325466f84144785da7Test
https://pubmed.ncbi.nlm.nih.gov/19404657Test

المؤلفون: Kusum Sharma, S S Banga, Lakhbir Kaur Dhaliwal, Meera Sharma, Sunil Sethi

المصدر: Sexually transmitted infections. 83(7)

مصطلحات موضوعية: Adult, medicine.medical_specialty, Pediatrics, Population, Developing country, India, Dermatology, Prenatal care, Abortion, Pregnancy, Prevalence, Medicine, Humans, Syphilis, Letters, Pregnancy Complications, Infectious, education, Socioeconomic status, education.field_of_study, business.industry, Obstetrics, Retrospective cohort study, Prenatal Care, medicine.disease, Infectious Diseases, Female, business

الوصف: Syphilis is a disease that has been around for a long time and that continues to challenge clinicians, including obstetricians.1 Maternal syphilis has a severe impact on pregnancy outcome, primarily as spontaneous abortion, still birth and congenital syphilis.2 Screening of asymptomatic antenatal women is recommended to prevent perinatal complications.3 In developing countries such as India, screening for syphilis during pregnancy is carried out by Veneral Disease Research Laboratory (VDRL) tests. We undertook this retrospective study to analyse trends in syphilis prevalence among antenatal women in a tertiary care hospital of north India. Laboratory log books of antenatal syphilis testing from 1996–2005 were reviewed. A total of 40 511 serum samples were obtained from pregnant women attending (during the period January 1996 to …

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24aece4b5dccc1c88eb692d9ab918726Test
https://pubmed.ncbi.nlm.nih.gov/18024713Test

المؤلفون: Nalini Gupta, Harsimran Kaur, Amit Roy, Lakhbir Kaur Dhaliwal, Nonika Rajkumari, Sunil Sethi

المصدر: Indian Journal of Sexually Transmitted Diseases

مصطلحات موضوعية: Infertility, medicine.medical_specialty, polymerase chain reaction, India, Mycoplasma genitalium, Dermatology, urologic and male genital diseases, Asymptomatic, Clinical history, Biopsy, medicine, Gynecology, Routine screening, medicine.diagnostic_test, biology, business.industry, Public Health, Environmental and Occupational Health, Endometrium biopsy, bacterial infections and mycoses, biology.organism_classification, medicine.disease, female genital diseases and pregnancy complications, Infectious Diseases, Original Article, medicine.symptom, infertility, business, Endometrial biopsy

الوصف: Objectives: Data regarding the association of Mycoplasma genitalium with infertility is scarce. This study was planned to look for the presence and association of M. genitalium in women with infertility. Materials and Methods: A prospective observational study was conducted on 100 cases of infertile women. The control group included 100 healthy fertile women. Samples of first void urine (FVU), endocervical swabs (ECS), and endometrial biopsies were subjected to polymerase chain reaction targeting MgPa gene to look for the presence of M. genitalium DNA. All endometrial biopsy samples were subjected to histopathological examination. A detailed clinical history of patients was taken, and all relevant investigations were recorded. Results: M. genitalium was found in 16% of women with infertility from either of the samples that is, FVU and/or ECS and/or endometrium biopsy, and none from controls. ECS and biopsy could detect the highest number of cases (27%). Asymptomatic cases predominated in the study and M. genitalium positivity (73.3%) was seen more in primary infertility. Tubal occlusion and disordered proliferative endometrium were demonstrated in 33% and 26.66% of M. genitalium positive cases respectively. Conclusions: The study shows an association of M. genitalium infection and infertility and suggests routine screening of this pathogen in patients with infertility.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d71bd3e510dd36a99d1fcc9be23706eTest
https://doi.org/10.4103/0253-7184.167141Test