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1
المؤلفون: Shenghua Wen, Srividya B. Balachander, Francis D. Gibbons, Michael Zinda, William McCoull, Nancy Su, Barry R. Davies, Stephen E. Kurtz, Terry MacIntyre, Edward J. Hennessy, Martin Wild, Paula Lewis, Ricky W. Johnstone, Jamal Carlos Saeh, Kathleen A. Burke, Omid Tavana, Andrea Newbold, Elizabeth A. Coker, Alwin Schuller, Justin Cidado, Diebold R Bruce, Tristan J. Lubinski, Steven Criscione, J. Paul Secrist, Kate Byth, Gareth P. Gregory, Deborah Lawson, Ammar Adam, Shannon K. McWeeney, Stephen Fawell, Thomas Gero, Jeffrey G. Varnes, Eric Gangl, Patricia Jaaks, Jeffrey W. Tyner, Mathew J. Garnett, Areya Tabatabai, Stephanos Ioannidis
المصدر: Clinical Cancer Research. 26:6535-6549
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, biology, Venetoclax, Chronic lymphocytic leukemia, Cancer, Myeloid leukemia, Bcl-xL, medicine.disease, 3. Good health, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Oncology, chemistry, In vivo, Apoptosis, 030220 oncology & carcinogenesis, biology.protein, medicine, Cancer research, B cell
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::564420d79c6feacf9af617f03b6937bcTest
https://doi.org/10.1158/1078-0432.ccr-20-0863Test -
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المؤلفون: James W.T. Yates, Karen Woods, Robert W. Wilkinson, Sarah V. Holt, Kirsty Payne, Barry R. Davies, Armelle Logie, Sylvie Guichard
المصدر: British Journal of Pharmacology. 174:2652-2661
مصطلحات موضوعية: 0301 basic medicine, Pharmacology, business.industry, In vitro, 03 medical and health sciences, Route of administration, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, MTOR Kinase Inhibitor AZD8055, chemistry, Pharmacokinetics, In vivo, 030220 oncology & carcinogenesis, Pharmacodynamics, Medicine, Growth inhibition, business, PI3K/AKT/mTOR pathway
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c7c579c415311078d93d157fb8710067Test
https://doi.org/10.1111/bph.13886Test -
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المؤلفون: Eric Gangl, Francis D. Gibbons, William McCoull, Martin Wild, Lorraine Graham, Hill Kathryn Jane, Brian Kelly, Srividya B. Balachander, David J. Owen, Sean Redmond, Marianne Ashford, Barry R. Davies, Alexander R. Harmer, Shenghua Wen, Iain Grant, Sonya Gales
المصدر: Cancer Research. 80:1718-1718
مصطلحات موضوعية: Cancer Research, Therapeutic index, Oncology, Tolerability, Chemistry, In vivo, Dendrimer, Pharmacology, Nanocarriers, Linker, Controlled release, Conjugate
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::8cc5b5a8344d601e4a673da8cfe48853Test
https://doi.org/10.1158/1538-7445.am2020-1718Test -
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المؤلفون: Charlene Fallan, Derek Barratt, Gillian M. Lamont, Elaine Cadogan, Frederick W. Goldberg, Mercedes Vazquez-Chantada, Antonio Ramos Montoya, Anna Cronin, Simon J. Hollingsworth, Andrew D. Campbell, D. Beattie, Raymond AstraZeneca R D Alderley Finlay, Jacqueline H. L. Fok, Emma Dean, Joanna Harding, Jane Norris, Attilla Ting, Barry R. Davies
المصدر: Cancer Research. 79:DDT01-02
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Kinase, DNA damage, DNA repair, Poly ADP ribose polymerase, Olaparib, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Oncology, chemistry, In vivo, 030220 oncology & carcinogenesis, Cancer research, Growth inhibition, IC50
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::55596045c1b3fd811eba667906d5e018Test
https://doi.org/10.1158/1538-7445.am2019-ddt01-02Test -
5
المؤلفون: Morris Jeffrey James, Gordon S. Currie, Jason Grant Kettle, Claire Crafter, Clare Lane, Ken Page, Peter Ballard, Linette Ruston, Hannah Dry, Martin Pass, Andrew G. Leach, Ryan Greenwood, Matt Addie, Judit E. Debreczeni, Johnson Paul David, Barry R. Davies, Gillian M. Lamont, Donald J. Ogilvie, David Buttar, Philippa Dudley, Richard W. A. Luke, Stuart E. Pearson
المصدر: Journal of Medicinal Chemistry. 56:2059-2073
مصطلحات موضوعية: Models, Molecular, medicine.drug_class, hERG, Administration, Oral, Carboxamide, Pharmacology, Inhibitory Concentration 50, Structure-Activity Relationship, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Humans, Structure–activity relationship, Pyrroles, Protein Kinase Inhibitors, Protein kinase B, biology, Chemistry, Kinase, Xenograft Model Antitumor Assays, Pyrimidines, Biochemistry, biology.protein, Molecular Medicine, Phosphorylation, Female, Proto-Oncogene Proteins c-akt, Drug metabolism
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e89f0e75ec3075ae6b777ac8b9c2c94Test
https://doi.org/10.1021/jm301762vTest -
6
المؤلفون: Gary Fairley, Clare Lane, Phillippa Dudley, Jason Grant Kettle, Janet Hawkins, Shaun M. Fillery, Helen Plant, Simon J. Brown, Paul Faulder, Claire Crafter, Jennifer H. Pink, Hannah Greenwood, Martin Pass, Sabina Cosulich, Barry R. Davies, Keith M. Johnson, Michael James
المصدر: Journal of Medicinal Chemistry. 55:1261-1273
مصطلحات موضوعية: Models, Molecular, Pyridines, Transplantation, Heterologous, Allosteric regulation, Biological Availability, Mice, Nude, Heterocyclic Compounds, 4 or More Rings, Mice, Structure-Activity Relationship, Allosteric Regulation, In vivo, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Protein kinase B, Gene knockdown, Chemistry, Imidazoles, Rats, Pyridazines, Transplantation, Biochemistry, Cell culture, Pyrazines, Quinazolines, Cancer research, Pyrazoles, Molecular Medicine, Phosphorylation, Drug Screening Assays, Antitumor, Heterocyclic Compounds, 3-Ring, Proto-Oncogene Proteins c-akt, Biomarkers, Neoplasm Transplantation
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4440805d2b64b8e0ab58f4d09a24381fTest
https://doi.org/10.1021/jm201394eTest -
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المؤلفون: Yurie Kura, Kazuhiro Yoshikawa, Barry R. Davies, Marco A. De Velasco, Hirotsugu Uemura, Kazuto Nishio
المصدر: Oncotarget
مصطلحات موضوعية: 0301 basic medicine, Male, PTEN, medicine.medical_treatment, Antineoplastic Agents, AKT inhibitor, Targeted therapy, 03 medical and health sciences, Prostate cancer, Mice, 0302 clinical medicine, In vivo, Medicine, Animals, Pyrroles, Protein kinase B, preclinical model, PI3K/AKT/mTOR pathway, Mice, Knockout, biology, business.industry, PTEN Phosphohydrolase, Cancer, Prostatic Neoplasms, medicine.disease, prostate cancer, targeted therapy, Disease Models, Animal, 030104 developmental biology, Pyrimidines, Oncology, 030220 oncology & carcinogenesis, Genetically Engineered Mouse, Immunology, biology.protein, Cancer research, Drug Screening Assays, Antitumor, Tumor Suppressor Protein p53, business, Genetic Engineering, Proto-Oncogene Proteins c-akt, Research Paper
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324f4918963eecfa6d2a4e517e29c994Test
https://pubmed.ncbi.nlm.nih.gov/26910118Test -
8
المؤلفون: Claire Crafter, Martin E. Gleave, Christian Thomas, Francois Lamoureux, Daksh Thaper, Eliana Beraldi, Amina Zoubeidi, Ladan Fazli, Soojin Kim, Barry R. Davies
المصدر: Journal of Urology. 189
مصطلحات موضوعية: Androgen receptor, Prostate cancer, business.industry, In vivo, Urology, Cancer research, Medicine, Castration resistant, business, medicine.disease, PI3K/AKT/mTOR pathway
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::da85b269e9cc306a686e2e6dfe666c06Test
https://doi.org/10.1016/j.juro.2013.02.1703Test -
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المؤلفون: Emiko Fukushima, Hayley Campbell, Masahiro Nozawa, Yuji Hatanaka, Nobutaka Shimizu, Marco A. De Velasco, Yurie Kura, Kazuhiro Yoshikawa, Barry R. Davies, Kazuhiro Yoshimura, Hirotsugu Uemura, Naomi Ando, Kazuto Nishio, Yutaka Yamamoto
المصدر: Cancer Research. 75:4212-4212
مصطلحات موضوعية: Cancer Research, biology, business.industry, medicine.drug_class, Cancer, medicine.disease, Androgen, Molecular biology, Androgen receptor, chemistry.chemical_compound, Prostate cancer, Castration, medicine.anatomical_structure, Oncology, chemistry, Prostate, In vivo, medicine, Cancer research, biology.protein, PTEN, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::224d4851f324b812885ac9d877364605Test
https://doi.org/10.1158/1538-7445.am2015-4212Test -
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المؤلفون: Linette Ruston, Helen Jones, Helen Musgrove, Leigh J. Williams, Barry R. Davies, Danielle Greenawalt, Dawn Trueman, Stephanie Klein
المصدر: Cancer Research. 75:5146-5146
مصطلحات موضوعية: Cancer Research, Bladder cancer, business.industry, Cancer, medicine.disease, Gemcitabine, Therapeutic index, Oncology, In vivo, Cancer cell, Immunology, medicine, Cancer research, Immunohistochemistry, business, Ex vivo, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ab41ce50bf88fbcd2d5b29614410d075Test
https://doi.org/10.1158/1538-7445.am2015-5146Test