Evaluation of Phagocytic Component of the Immune System in Patients with Organic Acidemia
| العنوان: | Evaluation of Phagocytic Component of the Immune System in Patients with Organic Acidemia |
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| المؤلفون: | Mehrnaz Mesdaghi, Hedyeh Saneifard, Shima Rasouli, Mohammad Reza Alaei, Marjan Shakiba, Faegheh Alizadeh Najjarbashi |
| المصدر: | Archives of Pediatric Infectious Diseases. |
| بيانات النشر: | Briefland, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, business.industry, Disease, 030105 genetics & heredity, Neutropenia, medicine.disease, Gastroenterology, 03 medical and health sciences, Infectious Diseases, medicine.anatomical_structure, Immune system, Bone marrow suppression, White blood cell, Internal medicine, Organic acidemia, Pediatrics, Perinatology and Child Health, Nbt test, Immunology, medicine, In patient, business |
| الوصف: | Background: There are several reports of recurrent infections in patients with organic acidemia. Almost all studies on the immune system of these patients have investigated the immune system in the acidotic phase of the disease. In the present study, the phagocytic component of the immune system was evaluated in patients with organic acidemia. Methods: After exclusion of patients in the acidotic phase of the disease, 31 patients with organic acidemia were included in the study. All patients completed the written informed consents, and the study was approved by the ethics committee of Mofid Children’s hospital. Information including age, sex, type of organic acidemia, and history of hospitalization due to infection was recorded. Screening tests of phagocytic component of the immune system, including total and differential white blood cell (WBC) count and nitroblue tetrazolium (NBT) test, were performed for all the patients. Results: The prevalence of neutropenia was high among patients (22.6%); it was even more frequent in patients younger than 3 years (42.6%). On the other hand, in most patients (93.5%), neutrophils showed normal function on the NBT test. Conclusions: Neutropenia in the nonacidotic phase of organic acidemia can be the cause of recurrent infections in these patients. It can be independent of bone marrow suppression, caused by reduced production of these cells as a result of reduced pH in the acidotic phase of the disease. |
| تدمد: | 2322-1836 2322-1828 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::bef8522a64b91c5b174b8cbab8024805Test https://doi.org/10.5812/pedinfect.61624Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........bef8522a64b91c5b174b8cbab8024805 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23221836 23221828 |
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