Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction (TUM9P.1007)
| العنوان: | Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction (TUM9P.1007) |
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| المؤلفون: | Ende Zhao, Tomasz Maj, Ilona Kryczek, Shuang Wei, Joel Crespo, Shanshan Wan, Linda Vatan, Wojciech Szeliga, Arul Chinnaiyan, Theodore Welling, Victor Marquez, Guobin Wang, Weiping Zou |
| المصدر: | The Journal of Immunology. 194:210.9-210.9 |
| بيانات النشر: | The American Association of Immunologists, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Immunology, Immunology and Allergy |
| الوصف: | Aerobic glycolysis regulates T cell function. However, if and how primary cancer alters effector T cell glycolytic metabolism and affects tumor immunity remains a question in cancer patients. Here we report that ovarian cancer imposes glucose restriction on effector T cells, dampens their function via maintaining high expression of microRNA101 and microRNA26a, which subsequently constrains EZH2 expression. EZH2 activates the Notch pathway by suppressing Notch repressors via H3K27me3, and consequently stimulates T cell polyfunctional cytokine expression and promotes their survival via Bcl-2 signaling. Moreover, EZH2-/- T cells elicit poor anti-tumor immunity and EZH2+CD8+ T cells are associated with improved long-term cancer patient survival. Together, our data unveil a novel metabolic target and mechanism of cancer immune evasion. |
| تدمد: | 1550-6606 0022-1767 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::50e2e81982b9f97960fbab2ff683d3e9Test https://doi.org/10.4049/jimmunol.194.supp.210.9Test |
| رقم الانضمام: | edsair.doi...........50e2e81982b9f97960fbab2ff683d3e9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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