المؤلفون: Xu, Tingting, Chen, Zijin, Jiang, Mengdi, Ma, Hunkun, Jin, Kexin, Wang, Zhiyu, Wang, Chongjian, Xu, Jing, Zhang, Wen

المصدر: RMD Open ; volume 8, issue 2, page e002424 ; ISSN 2056-5933

مصطلحات موضوعية: Immunology, Immunology and Allergy, Rheumatology

الوصف: Objectives This study aimed to explore clinical features of early infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV) and to identify the association between the infection profile of patients with AAV during the first 3 months and 1-year survival. Methods A total of 415 newly diagnosed patients with AAV in the Department of Nephrology at Shanghai Ruijin Hospital from 2000 to 2018 were included. Four Cox regression models were used to analyse the association based on demographics, comorbidities, laboratory baseline index and therapy parameter. Infection screening was carried out monthly during the first 3 months after diagnosis. Results In all, 377 episodes of infection were identified among 220 patients during the first 3 months. The overall survival after 1 year was 73.0%. Respiratory infection (210 episodes/164 persons) accounted for more than half of infections. Infection was independently associated with 1-year mortality (adjusted HR 2.32, 95% CI 1.27 to 4.23, p=0.006) after adjustment. Respiratory infection (adjusted HR 4.36, 95% CI 2.86 to 8.06, p<0.001), Gram-negative bacterial infection (adjusted HR 1.71, 95% CI 1.01 to 2.91, p=0.047) and fungal infection (adjusted HR 1.77, 95% CI 1.07 to 2.94, p=0.026) was identified as a risk factor for 1-year mortality. Trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis (adjusted HR 0.55, 95% CI 0.31 to 0.97, p=0.040) was protective for 1-year mortality. Conclusions Infections, particularly respiratory infections, are a common and important class of complication in patients with AAV and are associated with early mortality. TMP-SMX prophylaxis might be necessary to improve short-term outcome. More consideration of infectious risk and regular infection screening should be given.

الإتاحة: https://doi.org/10.1136/rmdopen-2022-002424Test

المؤلفون: Li, Pengchong, Jiang, Mengdi, Li, Ketian, Li, Hao, Zhou, Yangzhong, Xiao, Xinyue, Xu, Yue, Krishfield, Suzanne, Lipsky, Peter E., Tsokos, George C., Zhang, Xuan

المساهمون: U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Natural Science Foundation of China

المصدر: Nature Immunology ; volume 22, issue 9, page 1107-1117 ; ISSN 1529-2908 1529-2916

مصطلحات موضوعية: Immunology, Immunology and Allergy

الإتاحة: https://doi.org/10.1038/s41590-021-00993-3Test
https://www.nature.com/articles/s41590-021-00993-3.pdfTest
https://www.nature.com/articles/s41590-021-00993-3Test

المؤلفون: Jiang, Mengdi, Li, Yueting, Jiang, Chendan, Zhao, Lidan, Zhang, Xuan, Lipsky, Peter E

المساهمون: National Natural Science Foundation of China, Chinese Academy of Medical Science Innovation Fund for Medical Sciences, Beijing Capital Health Development Fund, Medical Epigenetics Research Center, Chinese Academy of Medical Sciences

المصدر: Clinical Reviews in Allergy & Immunology ; volume 60, issue 1, page 96-110 ; ISSN 1080-0549 1559-0267

مصطلحات موضوعية: General Medicine, Immunology and Allergy

الإتاحة: https://doi.org/10.1007/s12016-020-08805-6Test