المؤلفون: Jack Fuhrer, Howard M. Heller

المصدر: AIDS. 5:1243-1246

مصطلحات موضوعية: Pathology, medicine.medical_specialty, Sporotrichosis, business.industry, Immunology, Disease, medicine.disease, Dermatology, Infectious Diseases, Acquired immunodeficiency syndrome (AIDS), Immunopathology, medicine, Immunology and Allergy, Viral disease, business, Fungemia, Mycosis, Dimorphic fungus

الوصف: Sporotrichosis is the disease caused by the dimorphic fungus Sporothrix schenkii. Disseminated sporotrichosis is an uncommon infection which usually occurs in alcoholics or patients receiving immunosuppressive medication. We report a case of a patient with AIDS who had disseminated sporotrichosis wh

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b5bd9ee04990082af4ea603b96de805cTest
https://doi.org/10.1097/00002030-199110000-00014Test

المؤلفون: Jack Fuhrer, Qaisar Afzal, Barbara Weiser, Alan J. Cohen

المصدر: AIDS. 4:807-810

مصطلحات موضوعية: Adult, Male, Ganciclovir, medicine.medical_specialty, medicine.medical_treatment, Immunology, Autopsy, Ventricular tachycardia, Acquired immunodeficiency syndrome (AIDS), Tachycardia, Internal medicine, Humans, Immunology and Allergy, Medicine, cardiovascular diseases, Acquired Immunodeficiency Syndrome, Cytomegalic inclusion disease, business.industry, virus diseases, Intravenous Infusions, Middle Aged, medicine.disease, Cytomegalovirus infection, Infectious Diseases, Cytomegalovirus Infections, HIV-1, cardiovascular system, Cardiology, Cardiac monitoring, business, medicine.drug

الوصف: We report two cases of patients who developed ventricular tachycardia while receiving intravenous infusions of ganciclovir [9-(1,3-dihydroxy-2-propoxy)methylguanine, DHPG]. Worsening cytomegalovirus infection prompted renewal of ganciclovir therapy under close cardiac monitoring in one of these patients, and ventricular tachycardia recurred. The close temporal relationship between administration of the drug and onset of the arrhythmias in conjunction with the absence of other factors known to predispose to arrhythmias suggest that ganciclovir may have played a role in the development of arrhythmias in these patients. The clinical courses of the patients are discussed, as are autopsy results.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e91b6ff3f5799b6a8dbccd421221acTest
https://doi.org/10.1097/00002030-199008000-00014Test

المؤلفون: Kim A. DeCristofaro, Margaret A. McNurlan, Charles H. Lang, Robert A. Frost, Jack Fuhrer, Peter J. Garlick, Roy T. Steigbigel, Sang Ahnn, Marie C. Gelato, Dennis C. Mynarcik

المصدر: Journal of acquired immune deficiency syndromes (1999). 22(1)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Secondary infection, Immunology, HIV Infections, Self Administration, HIV Wasting Syndrome, Glucagon, Insulin-like growth factor-binding protein, Injections, Insulin-like growth factor, Weight loss, Virology, Internal medicine, Weight Loss, medicine, Immunology and Allergy, Humans, Insulin, Insulin-Like Growth Factor I, Wasting, Acquired Immunodeficiency Syndrome, biology, Human Growth Hormone, Insulin-Like Growth Factor Binding Protein 1, Insulin-Like Growth Factor Binding Proteins, Insulin-Like Growth Factor Binding Protein 2, Endocrinology, Insulin-Like Growth Factor Binding Protein 3, Case-Control Studies, Growth Hormone, biology.protein, Female, medicine.symptom, Hormone

الوصف: The purpose of this study was to characterize changes in the levels of insulin-like growth factor-I (IGF-I) and IGF binding proteins (BP) 1, 2, and 3 in HIV-infected adults throughout the course of their disease, and to assess the responsiveness of the IGF system components to growth hormone (GH) administration (6 mg/day) for 2 weeks. Healthy control study subjects (n = 10) were compared with patients who were either HIV-positive (n = 9), had AIDS without weight loss (n = 13), or had AIDS with >10% weight loss (n = 6), all of whom had been free of acute illness for at least 3 months. Under basal conditions, fasting serum concentrations of epinephrine, norepinephrine, cortisol, glucagon, insulin, IGF-I, and IGFBP-3 were not significantly different among the four groups. The serum concentrations of IGFBP-1 and IGFBP-2 were significantly higher in AIDS patients with wasting than in the other three groups (p < .05). In addition, there was a statistically significant positive correlation between the levels of IGFBP- 1 (p = .004) and IGFBP-2 (p = .03) and the stage of disease. Following GH administration, the serum concentrations of insulin and IGF-I were increased in all groups (p < .05). In addition, the increases in insulin levels correlated with stage of disease (p = .004). The responses of the IGFBPs were more variable. GH administration significantly increased the levels of IGFBP-3 in all groups except the patients with AIDS wasting, whereas the levels of IGFBP-1 were significantly decreased in controls and AIDS patients. These results demonstrate that there is a continuum of both elevations in the IGFBPs and altered metabolic responsiveness in patients infected with HIV that increases with the severity of the disease. These data also demonstrate that AIDS patients, who are free from secondary infection, respond to administration of GH by significantly increasing hepatic IGF-I production.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b05db35b2aa89d2037c540a03fdf8dTest
https://pubmed.ncbi.nlm.nih.gov/10534146Test