المؤلفون: Maspero, Jorge, Fiocchi, Alessandro, Deschildre, Antoine, Bacharier, Leonard, Altincatal, Arman, Laws, Elizabeth, Lederer, David, Akinlade, Bolanle, Hardin, Megan

المصدر: Journal of Allergy and Clinical Immunology ; volume 151, issue 2, page AB18 ; ISSN 0091-6749

مصطلحات موضوعية: Immunology, Immunology and Allergy

الإتاحة: https://doi.org/10.1016/j.jaci.2022.12.059Test
https://api.elsevier.com/content/article/PII:S0091674922017134?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0091674922017134?httpAccept=text/plainTest

المؤلفون: Chipps, Bradley E., Lanier, Bob, Milgrom, Henry, Deschildre, Antoine, Hedlin, Gunilla, Szefler, Stanley J., Kattan, Meyer, Kianifard, Farid, Ortiz, Benjamin, Haselkorn, Tmirah, Iqbal, Ahmar, Rosén, Karin, Trzaskoma, Benjamin, Busse, William W.

المصدر: Journal of Allergy and Clinical Immunology ; volume 139, issue 5, page 1431-1444 ; ISSN 0091-6749

مصطلحات موضوعية: Immunology, Immunology and Allergy

الإتاحة: https://doi.org/10.1016/j.jaci.2017.03.002Test
https://api.elsevier.com/content/article/PII:S0091674917304104?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0091674917304104?httpAccept=text/plainTest

المؤلفون: Pouessel, Guillaume, Claverie, Claire, Labreuche, Julien, Dorkenoo, Aimée, Renaudin, Jean-Marie, Eb, Mireille, Lejeune, Stéphanie, Deschildre, Antoine, Leteurtre, Stéphane

المصدر: Journal of Allergy and Clinical Immunology ; volume 140, issue 2, page 610-612.e2 ; ISSN 0091-6749

مصطلحات موضوعية: Immunology, Immunology and Allergy

الإتاحة: https://doi.org/10.1016/j.jaci.2017.02.014Test
https://api.elsevier.com/content/article/PII:S0091674917303421?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0091674917303421?httpAccept=text/plainTest

المؤلفون: Turner, Paul J., Patel, Nandinee, Mäkelä, Mika J., Kukkonen, Kaarina, Deschildre, Antoine, Blumchen, Katharina, Rodríguez del Río, Pablo, Fernández-Rivas, Montserrat, Alvaro-Lozano, Montserrat, Beyer, Kirsten

المصدر: Journal of Allergy and Clinical Immunology ; volume 150, issue 5, page 1242-1244 ; ISSN 0091-6749

مصطلحات موضوعية: Immunology, Immunology and Allergy

الإتاحة: https://doi.org/10.1016/j.jaci.2022.07.012Test
https://api.elsevier.com/content/article/PII:S0091674922010223?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0091674922010223?httpAccept=text/plainTest

المؤلفون: Vickery, Brian, du Toit, George, Ratnayake, Anoshie, Blumchen, Katharina, Sharma, Vibha, Chapman, John, Deschildre, Antoine, Sher, Lawrence, Norval, David, Adelman, Daniel, Beyer, Kirsten, Casale, Thomas, Greiner, Alexander, Cox, Amanda, Robison, Rachel, Brown, Kari, Scurlock, Amy

المصدر: Journal of Allergy and Clinical Immunology ; volume 149, issue 2, page AB31 ; ISSN 0091-6749

مصطلحات موضوعية: Immunology, Immunology and Allergy

الإتاحة: https://doi.org/10.1016/j.jaci.2021.12.136Test
https://api.elsevier.com/content/article/PII:S009167492101959X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S009167492101959X?httpAccept=text/plainTest

المؤلفون: Nicola A, Hanania, Robert, Niven, Pascal, Chanez, Deschildre, Antoine, Pascal, Pfister, Lorena, Garcia Conde, Xavier, Jaumont

المصدر: World Allergy Organization Journal. 15:100695

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Immunology, Immunology and Allergy

الوصف: Omalizumab is recommended as an add-on therapy in patients aged ≥6 years with inadequately controlled, moderate-to-severe persistent allergic asthma. The efficacy and safety of omalizumab treatment in allergic asthma clinical trials and its effectiveness in the real world have been reported in numerous studies. In this review, we examine clinical evidence in pediatric and adult patients with allergic asthma who received omalizumab treatment for at least 2 years, to assess its effectiveness, durability, and trajectory of response over time as well as safety. We performed a literature search from inception until March 2022 in PubMed using the keywords "omalizumab" and "allergic asthma" to retrieve articles examining the effects of omalizumab in patients with allergic asthma, aged ≥6 years. Only articles that evaluated the effectiveness of omalizumab for at least 2 years were included. Data from case reports were excluded. Our review confirmed the long-term effectiveness and safety of omalizumab, demonstrating reduced rate of exacerbations, improved lung function, asthma control, and quality of life, decreased health care resource utilization, and use of corticosteroids (oral/inhaled) with a favorable safety and tolerability profile for up to 9 years in adult patients with moderate-to-severe allergic asthma. Similar results were also observed in the pediatric population with up to 7.5 years of omalizumab treatment. This review highlights and confirms the sustained clinical benefits of omalizumab over long periods of treatment in pediatric and adult populations with allergic asthma.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13584fb1542dccc935c696ba93b5db2fTest
https://doi.org/10.1016/j.waojou.2022.100695Test

المؤلفون: Deschildre, Antoine

المصدر: Revue Française d'Allergologie ; volume 61, issue 4, page 213-215 ; ISSN 1877-0320

مصطلحات موضوعية: Immunology and Allergy

الإتاحة: https://doi.org/10.1016/j.reval.2021.02.007Test
https://api.elsevier.com/content/article/PII:S1877032021000646?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1877032021000646?httpAccept=text/plainTest

المؤلفون: Papadopoulos, Nikolaos G., Mathioudakis, Alexander G., Custovic, Adnan, Deschildre, Antoine, Phipatanakul, Wanda, Wong, Gary, Xepapadaki, Paraskevi, Abou‐taam, Rola, Agache, Ioana, Castro‐rodriguez, Jose A., Chen, Zhimin, Cros, Pierrick, Dubus, Jean‐christophe, El‐sayed, Zeinab Awad, El‐owaidy, Rasha, Feleszko, Wojciech, Fierro, Vincenzo, Fiocchi, Alessandro, Garcia‐marcos, Luis, Goh, Anne, Hossny, Elham M., Huerta Villalobos, Yunuen R., Jartti, Tuomas, Le Roux, Pascal, Levina, Julia, López García, Aida Inés, Ramos, Ángel Mazón, Morais‐almeida, Mário, Murray, Clare, Nagaraju, Karthik, Nagaraju, Major K., Navarrete Rodriguez, Elsy Maureen, Namazova‐baranova, Leyla, Nieto Garcia, Antonio, Pozo Beltrán, Cesar Fireth, Ratchataswan, Thanaporn, Rivero Yeverino, Daniela, Rodríguez Zagal, Eréndira, Schweitzer, Cyril E., Tulkki, Marleena, Wasilczuk, Katarzyna, Xu, Dan, Alekseeva, Anna, Almeida, Bethan, Andre, Maud, Arimova, Polina, Blonde, Aurore, Cunningham, Amparito, Da Mota, Sofia, Efendieva, Kamilla, Kalugina, Vera, Kiefer, Sébastien, Klein, Anais, López, Chrystopherson Gengyny Caballero, López, Juan Jesús Ríos, Moratellti, Caroline, Fuentes Pérez, Miguel, Simermann, Meryl, Tapia, José Sergio Papaqui, Tatopoulos, Aurelie, Vishneva, Elena, Volkov, Κonstantin, Bacharier, Leonard, Bonini, Matteo, Craig, Timothy, Diamant, Zuzana, Ducharme, Francine M, Gern, James E., Grigg, Jonathan, Hamelmann, Eckard H, Hedlin, Gunilla, Kalayci, Omer, Kaplan, Alan, Konradsen, Jon, Kuna, Piotr, Lau, Susanne, Le Souef, Peter, Lemanske, Robert F, Makela, Mika J, Matricardi, Paolo M, Gómez, René‐maximiliano, Miligkos, Michael, Pitrez, Paulo Mc, Price, David, Pohunek, Petr, Roberts, Graham C, Sheikh, Aziz, Tsiligianni, Ioanna, Turner, Steve, Valiulis, Arunas, Winders, Tonya, Yusuf, Osman M, Zar, Heather

المساهمون: University of Manchester [Manchester], Pneumologie et allergologie pédiatriques [CHU Jeanne de Flandre, Lille], Hôpital Jeanne de Flandre [Lille], Université de Lille, The Chinese University of Hong Kong [Hong Kong], Department of Nutrition and Dietetics [Athens, Greece], Harokopio University [Athens, Greece], Transilvania University of Brasov, CHRU de Brest - Département de Pédiatrie (CHU BREST Pédiatrie), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Service de pédiatrie spécialisée et médecine infantile (neurologie, pneumologie, maladies héréditaires du métabolisme) [Hôpital de la Timone - APHM], Hôpital de la Timone [CHU - APHM] (TIMONE), Medical University of Warsaw - Poland, Bambino Gesù Children’s Hospital [Rome, Italy]

المصدر: Papadopoulos, N G, Mathioudakis, A G, Custovic, A, Deschildre, A, Phipatanakul, W, Wong, G, Xepapadaki, P, Abou-taam, R, Agache, I, Castro-rodriguez, J A, Chen, Z, Cros, P, Dubus, J, El-sayed, Z A, El-owaidy, R, Feleszko, W, Fierro, V, Fiocchi, A, Garcia-marcos, L, Goh, A, Hossny, E M, Huerta Villalobos, Y R, Jartti, T, Le Roux, P, Levina, J, López García, A I, Ramos, Á M, Morais-almeida, M, Murray, C, Nagaraju, K, Nagaraju, M K, Navarrete Rodriguez, E M, Namazova-baranova, L, Nieto Garcia, A, Pozo Beltrán, C F, Ratchataswan, T, Rivero Yeverino, D, Rodríguez Zagal, E, Schweitzer, C E, Tulkki, M, Wasilczuk, K, Xu, D, Alekseeva, A, Almeida, B, Andre, M, Arimova, P, Blonde, A, Cunningham, A, Da Mota, S, Efendieva, K, Kalugina, V, Kiefer, S, Klein, A, López, C G C, López, J J R, Moratellti, C, Fuentes Pérez, M, Simermann, M, Tapia, J S P, Tatopoulos, A, Vishneva, E, Volkov, Κ, Bacharier, L, Bonini, M, Craig, T, Diamant, Z, Ducharme, F M, Gern, J E, Grigg, J, Hamelmann, E H, Hedlin, G, Jartti, T, Kalayci, O, Kaplan, A, Konradsen, J, Kuna, P, Lau, S, Le Souef, P, Lemanske, R F, Makela, M J, Matricardi, P M, Gómez, R, Miligkos, M, Pitrez, P M, Price, D, Pohunek, P, Roberts, G C, Sheikh, A, Tsiligianni, I, Turner, S, Valiulis, A, Winders, T, Yusuf, O M & Zar, H 2021, ' Childhood asthma outcomes during the COVID-19 pandemic: Findings from the PeARL multi-national cohort ', Allergy . https://doi.org/10.1111/all.14787Test
Allergy, Hoboken : John Wiley and Sons Inc, 2021, vol. 76, iss. 6, p. 1765-1775
Allergy
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Allergy, 2021, 76 (6), pp.1765-1775. ⟨10.1111/all.14787⟩

مصطلحات موضوعية: 0301 basic medicine, Pediatrics, Allergy, coronavirus, CHILDREN, Pulmonary function testing, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, immune system diseases, childhood asthma, Pandemic, Immunology and Allergy, Medicine, Outpatient clinic, Child, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Respiratory tract infections, Minimal clinically important difference, PeARL collaborators, on behalf of the PeARL Think Tank, Hospitalization, 1107 Immunology, Child, Preschool, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Cohort, Original Article, PEDIATRIC ASTHMA, COVID-19, Life Sciences & Biomedicine, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Adolescent, Immunology, VALIDATION, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, COVID‐19, Humans, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Risk factor, Pandemics, Asthma, Childhood asthma, Science & Technology, SARS-CoV-2, business.industry, Original Articles, medicine.disease, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, respiratory tract diseases, EXACERBATIONS, 030104 developmental biology, 030228 respiratory system, Emergency medicine, business, ACUTE RESPIRATORY SYNDROME

الوصف: Background The interplay between COVID‐19 pandemic and asthma in children is still unclear. We evaluated the impact of COVID‐19 pandemic on childhood asthma outcomes. Methods The PeARL multinational cohort included 1,054 children with asthma and 505 non‐asthmatic children aged between 4 and 18 years from 25 pediatric departments, from 15 countries globally. We compared the frequency of acute respiratory and febrile presentations during the first wave of the COVID‐19 pandemic between groups and with data available from the previous year. In children with asthma, we also compared current and historical disease control. Results During the pandemic, children with asthma experienced fewer upper respiratory tract infections, episodes of pyrexia, emergency visits, hospital admissions, asthma attacks, and hospitalizations due to asthma, in comparison with the preceding year. Sixty‐six percent of asthmatic children had improved asthma control while in 33% the improvement exceeded the minimal clinically important difference. Pre‐bronchodilatation FEV1 and peak expiratory flow rate were improved during the pandemic. When compared to non‐asthmatic controls, children with asthma were not at increased risk of LRTIs, episodes of pyrexia, emergency visits, or hospitalizations during the pandemic. However, an increased risk of URTIs emerged. Conclusion Childhood asthma outcomes, including control, were improved during the first wave of the COVID‐19 pandemic, probably because of reduced exposure to asthma triggers and increased treatment adherence. The decreased frequency of acute episodes does not support the notion that childhood asthma may be a risk factor for COVID‐19. Furthermore, the potential for improving childhood asthma outcomes through environmental control becomes apparent.
This study evaluates the frequency of acute respiratory and febrile presentations furing the first wave of COVID‐19 pandemic in childhood asthma. Data from the multinational PeARL cohort reveal improved health and asthma activity during the first wave of the COVID‐19 pandemic, probably attributed to decreased exposure to asthma triggers and increased treatment adherence. During that period, children with asthma experienced fewer URTIs, episodes of pyrexia, emergency visits, hospital admissions, asthma attacks and hospitalizations due to asthma, in comparison to the preceding year.

وصف الملف: application/pdf; text

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c1759801c82ba54b9e773ff224c217Test
http://hdl.handle.net/10044/1/86246Test

المؤلفون: Mathioudakis, Alexander G., Custovic, Adnan, Deschildre, Antoine, Ducharme, Francine M., Kalayci, Omer, Murray, Clare, Garcia, Antonio Nieto, Phipatanakul, Wanda, Price, David, Sheikh, Aziz, Agache, Ioana, Bacharier, Leonard, Bonini, Matteo, Castro-Rodriguez, Jose A., De Carlo, Giuseppe, Craig, Timothy, Diamant, Zuzana, Feleszko, Wojciech, Ierodiakonou, Despo, Gern, James E., Grigg, Jonathan, Hedlin, Gunilla, Hossny, Elham M., Jartti, Tuomas, Kaplan, Alan, Lemanske, Robert F., Le Souef, Peter, Makela, Mika J., Matricardi, Paolo M., Miligkos, Michael, Morais-Almeida, Mário, Pite, Helena, Pitrez, Paulo M.C., Pohunek, Petr, Roberts, Graham, Sanchez-Garcia, Sylvia, Tsiligianni, Ioanna, Turner, Steve, Winders, Tonya A., Wong, Gary, Xepapadaki, Paraskevi, Zar, Heather J., Papadopoulos, Nikolaos G.

المساهمون: Respiratory Effectiveness Group, AstraZeneca, Novartis, Sanofi, National Institute of Health Research Manchester Biomedical Research Centre, Boehringer Ingelheim, Stallergenes Greer, Thorasys Inc., Trudell Medical, Genentech, Regeneron, Thermo Fisher, Lincoln Diagnostics, ALK-Abello, Monaghen, AKL Research and Development Ltd, British Lung Foundation, UK National Health Service, Chiesi, Circassia, Mylan, Mundipharma, Napp, Pfizer, Regeneron Pharmaceuticals, Sanofi Genzyme, Teva, Theravance, Zentiva, Sanofi Generics, Efficacy and Mechanism Evaluation program, CSL Behring, Dyax, Takeda, BioCryst, Pharming, GSK, National Institutes of Health, National Institute of Allergy and Infectious Diseases, NIH, GlaxoSmithKline, Boehringer-Ingelheim, Merck, TEVA, American Academy of Allergy Asthma and Immunology, Clinical and Translational Science, Childhood Origins of ASThma, AsthmaNet, Astra Zeneca, GSK Hellas, Gerolymatos International SA

المصدر: The Journal of Allergy and Clinical Immunology: In Practice ; volume 8, issue 6, page 1953-1960.e9 ; ISSN 2213-2198

مصطلحات موضوعية: Immunology and Allergy

الإتاحة: https://doi.org/10.1016/j.jaip.2020.01.059Test
https://api.elsevier.com/content/article/PII:S2213219820301471?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2213219820301471?httpAccept=text/plainTest

المؤلفون: Papadopoulos, Nikolaos G, Čustović, Adnan, Cabana, Michael D., Lee, Philip R., Dell, Sharon D., Deschildre, Antoine, Hedlin, Gunilla, Hossny, Elham, Le Souëf, Peter, Matricardi, Paolo M., Nieto, Antonio, Phipatanakul, Wanda, Pitrez, Paulo M., Pohunek, Petr, Gavornikova, Marcela, Jaumont, Xavier, Price, David B

المساهمون: University of Aberdeen.Institute of Applied Health Sciences, University of Aberdeen.Other Applied Health Sciences

مصطلحات موضوعية: asthma management, omalizumab, pediatric asthma, unmet need, Humans, United Kingdom, Asthma/drug therapy, Glucocorticoids/therapeutic use, Omalizumab/adverse effects, Health Services Needs and Demand, Delivery of Health Care/methods, Adolescent, Anti-Asthmatic Agents/adverse effects, Child, Practice Guidelines as Topic, BONE-MINERAL DENSITY, INHALED CORTICOSTEROIDS, PREDICTIVE-VALUE, IGE RESPONSES, ALLERGIC-ASTHMA, MANAGEMENT, CHILDHOOD, CHILDREN, DOUBLE-BLIND, RJ Pediatrics, Pediatrics, Perinatology, and Child Health, Immunology and Allergy, Immunology

الوصف: The authors acknowledge Pascal Pfister for his support during the development of this manuscript. The authors also thank Gillian Lavelle PhD, of Novartis Product Lifecycle Services, Dublin, Ireland for providing medical writing support, which was funded by Novartis Pharma AG, Basel, Switzerland, in accordance with Good Publication Practice (GPP3) guidelines (http://www.ismpp.org/gpp3Test). ; Peer reviewed

وصف الملف: application/pdf

العلاقة: Pediatric Allergy & Immunology; 140158258; b1e46564-3779-4505-9b6b-3ec9d8c02e65; 85056461048; 000457444400002; Papadopoulos , N G , Čustović , A , Cabana , M D , Lee , P R , Dell , S D , Deschildre , A , Hedlin , G , Hossny , E , Le Souëf , P , Matricardi , P M , Nieto , A , Phipatanakul , W , Pitrez , P M , Pohunek , P , Gavornikova , M , Jaumont , X & Price , D B 2019 , ' Pediatric asthma : an unmet need for more effective, focused treatments ' , Pediatric Allergy & Immunology , vol. 30 , no. 1 , pp. 7-16 . https://doi.org/10.1111/pai.12990Test; Mendeley: 12084594-750a-3999-808e-a9af90588124; http://hdl.handle.net/2164/11870Test; http://www.scopus.com/inward/record.url?scp=85056461048&partnerID=8YFLogxKTest; http://www.mendeley.com/research/pediatric-asthma-unmet-need-more-effective-focused-treatmentsTest

الإتاحة: https://doi.org/10.1111/pai.12990Test
http://hdl.handle.net/2164/11870Test
http://www.scopus.com/inward/record.url?scp=85056461048&partnerID=8YFLogxKTest
http://www.mendeley.com/research/pediatric-asthma-unmet-need-more-effective-focused-treatmentsTest