Detecting Genetic Associations between ATG5 and Lupus Nephritis by trans-eQTL
| العنوان: | Detecting Genetic Associations between ATG5 and Lupus Nephritis by trans-eQTL |
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| المؤلفون: | Hong Zhang, Ming-Hui Zhao, Fa-juan Cheng, Ping Hou, Xu-jie Zhou, Yue-miao Zhang, Yuan-yuan Qi |
| المصدر: | Journal of Immunology Research Journal of Immunology Research, Vol 2015 (2015) |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | lcsh:Immunologic diseases. Allergy, Adult, Male, Article Subject, Genotype, Immunology, Lupus nephritis, Gene Expression, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, Autophagy-Related Protein 5, Young Adult, Asian People, Gene Frequency, Polymorphism (computer science), Databases, Genetic, medicine, Immunology and Allergy, Humans, Lupus Erythematosus, Systemic, Genetic Predisposition to Disease, Genotyping, Allele frequency, Genetic Association Studies, Oligonucleotide Array Sequence Analysis, Genetics, Lupus erythematosus, General Medicine, medicine.disease, Lupus Nephritis, Expression quantitative trait loci, Female, lcsh:RC581-607, Microtubule-Associated Proteins, Research Article |
| الوصف: | Objectives. Numerous loci were identified to perturb gene expression intrans. As elevatedATG5expression was observed in systemic lupus erythematosus (SLE), the study was conducted to analyze the genome-wide genetic regulatory mechanisms associated withATG5expression in a Chinese population with lupus nephritis (LN).Methods. The online expression quantitative trait loci database was searched fortrans-expression single nucleotide polymorphisms (trans-eSNPs) ofATG5. Taggingtrans-eSNPs were genotyped by a custom-made genotyping chip in 280 patients and 199 controls. For positive findings, clinical information and bioinformation analyses were performed.Results. Fourtrans-eSNPs were observed to be associated with susceptibility to LN (P< 0.05), including ANKRD50 rs17008504, AGA rs2271100, PAK7 rs6056923, and TET2 rs1391441, while seven othertrans-eSNPs showed marginal significant associations (0.05 |
| وصف الملف: | text/xhtml |
| تدمد: | 2314-7156 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23fdff44a3b3109be6e217ba5b1ca7e2Test https://pubmed.ncbi.nlm.nih.gov/26509176Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....23fdff44a3b3109be6e217ba5b1ca7e2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23147156 |
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