Inflammasome signaling in human placental trophoblasts regulates immune defense against Listeria monocytogenes infection
| العنوان: | Inflammasome signaling in human placental trophoblasts regulates immune defense against Listeria monocytogenes infection |
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| المؤلفون: | Carolyn B. Coyne, Dhivyaa Rajasundaram, Stefanie A. Morosky, Christina Megli |
| المصدر: | The Journal of Experimental Medicine |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Inflammasomes, THP-1 Cells, medicine.medical_treatment, Immunology, Interleukin-1beta, Innate Immunity and Inflammation, Biology, Insights, Monocytes, Infectious Disease and Host Defense, 03 medical and health sciences, 0302 clinical medicine, Placenta, medicine, Immunology and Allergy, Humans, Secretion, Listeriosis, reproductive and urinary physiology, Fetus, Interleukin-18, Inflammasome, Listeria monocytogenes, Cell biology, Trophoblasts, 030104 developmental biology, Cytokine, medicine.anatomical_structure, embryonic structures, Chorionic villi, Interleukin 18, Female, Signal transduction, Caco-2 Cells, Chorionic Villi, 030215 immunology, medicine.drug, Signal Transduction |
| الوصف: | Midgestation induces inflammasome signaling in placental trophoblasts to promote fetal and maternal antimicrobial defense during pregnancy. The placenta is thus a dynamic immunological organ. The second trimester of pregnancy is traditionally viewed as an immunosuppressive state. Megli et al. (https://doi.org/10.1084/jem.20200649Test) change this paradigm, showing that midgestation induces inflammasome signaling in placental trophoblasts to promote fetal and maternal antimicrobial defense. The placenta is thus a dynamic immunological organ. |
| تدمد: | 1540-9538 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac4337e0cb3a93237f86de74055a2d1Test https://pubmed.ncbi.nlm.nih.gov/33175107Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fac4337e0cb3a93237f86de74055a2d1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15409538 |
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