A HTLV-I Carrier Who Showed Various Symptoms and Antibodies of Autoimmune Diseases
| العنوان: | A HTLV-I Carrier Who Showed Various Symptoms and Antibodies of Autoimmune Diseases |
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| المؤلفون: | Masaru Shibano, Kiyoshi Takatsuki, Mitsuo Hashimoto, Masao Mizuki, Takashi Machii, Junzo Nojima, Yuji Okamoto, Teruo Kitani, Kozo Hashimoto, Yutaka Onoi, Sumio Kawata, Shinichi Tagawa, Kenmei Sakata |
| المصدر: | Internal Medicine. 32:449-454 |
| بيانات النشر: | Japanese Society of Internal Medicine, 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | Adult, Pathology, medicine.medical_specialty, Polyradiculoneuropathy, Polymerase Chain Reaction, Autoimmune Diseases, Mixed connective tissue disease, Primary biliary cirrhosis, Antibody Specificity, HLA Antigens, Internal Medicine, medicine, Humans, Lymphocytes, Autoantibodies, Mixed Connective Tissue Disease, Autoimmune disease, Human T-lymphotropic virus 1, biology, Deltaretrovirus Antibodies, Liver Cirrhosis, Biliary, business.industry, Antibody titer, General Medicine, medicine.disease, HTLV-I Infections, Connective tissue disease, Peripheral blood lymphocyte, Carrier State, DNA, Viral, Immunology, biology.protein, Prednisone, Female, Disease Susceptibility, Antibody, business, Anti-mitochondrial antibody |
| الوصف: | We report a 37-year-old female HTLV-I carrier with complicating primary biliary cirrhosis (PBC) and mixed connective tissue disease (MCTD). Serum anti-HTLV-I antibody titer was ×256. Flower cells (4.5%) were found in the peripheral blood. Southern blot analysis showed no clonal integration in peripheral blood lymphocyte (PBL) DNA. Polymerase chain reaction showed the HTLV-I genome in PBLDNA. As cholestatic liver dysfunction and serum titer of anti-mitochondrial antibody were found, a clinical diagnosis of PBC was made. This patient later developed MCTD. These diseases responded well to prednisone. The pathogenetic relationship of HTLV-I infection with various autoimmune diseases is discussed.(Internal Medicine 32: 449-454, 1993) |
| تدمد: | 1349-7235 0918-2918 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f7cc95d9608c831677cf397b3a4b3fTest https://doi.org/10.2169/internalmedicine.32.449Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c2f7cc95d9608c831677cf397b3a4b3f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13497235 09182918 |
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