التفاصيل البيبلوغرافية
| العنوان: |
B cell reconstitution after rituximab treatment of lymphoma recapitulates B cell ontogeny |
| المؤلفون: |
Anolik, Jennifer H. jennifer_anolik@urmc.rochester.edu, Friedberg, Jonathan W.1, Zheng, Bo1, Barnard, Jennifer1, Owen, Teresa1, Cushing, Emily1, Kelly, Jennifer1, Milner, Eric C.B.1, Fisher, Richard I.1, Sanz, Iñaki1 |
| المصدر: |
Clinical Immunology. Feb2007, Vol. 122 Issue 2, p139-145. 7p. |
| مصطلحات موضوعية: |
*B cells, *RITUXIMAB, *LYMPHOMAS, *IMMUNOLOGY, *IMMUNE system, *BONE marrow transplantation |
| مستخلص: |
Abstract: The long-term immunologic effects of B cell depletion with rituximab and the characteristics of the reconstituting B cell pool in lymphoma patients are not well defined, despite the widespread usage of this therapy. Here we report that during the B cell reconstitution phase a majority of the peripheral blood B cells have an immature transitional phenotype (47.8%±25.2% vs. 4.4%±2.4% for normal controls, p <0.0001), similar to what has been described during the original ontogeny of the immune system and following bone marrow transplantation. Moreover, the recovery of the CD27+ memory B cell pool was delayed compared to normal B cell ontogeny, remaining below normal controls at 1 year post-rituximab (4.4%±3% vs. 31%±7%, p <0.0001). Expansion of functionally immature B cells and decreased memory B cells may contribute to an immunodeficient state in patients recovering from rituximab mediated B cell depletion, particularly with repeated treatment. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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