Quantification of γδ T cells and HLA-DR+ NK cells does not predict emergence of new contrast enhancing lesions in MS patients suspending natalizumab treatment
| العنوان: | Quantification of γδ T cells and HLA-DR+ NK cells does not predict emergence of new contrast enhancing lesions in MS patients suspending natalizumab treatment |
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| المؤلفون: | Paužuolis, Mindaugas, Eich, Torsten, Burman, Joachim |
| المصدر: | PLoS ONE PLoS ONE, Vol 12, Iss 6, p e0179095 (2017) |
| بيانات النشر: | Uppsala universitet, Institutionen för biologisk grundutbildning, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | CD4-Positive T-Lymphocytes, Male, Neurologi, lcsh:Medicine, NK cells, Pathology and Laboratory Medicine, Diagnostic Radiology, White Blood Cells, Spectrum Analysis Techniques, Animal Cells, Recurrent Diseases, Medicine and Health Sciences, lcsh:Science, T Cells, Radiology and Imaging, Natalizumab, Neurodegenerative Diseases, Middle Aged, Flow Cytometry, Magnetic Resonance Imaging, Killer Cells, Natural, Neurology, Spectrophotometry, Cell Tracking, Female, Cytophotometry, Cellular Types, Research Article, Adult, Multiple Sclerosis, Imaging Techniques, Immune Cells, Immunology, Cell Enumeration Techniques, Research and Analysis Methods, Antibodies, Monoclonal, Humanized, Autoimmune Diseases, Signs and Symptoms, Diagnostic Medicine, parasitic diseases, Humans, Inflammation, Blood Cells, lcsh:R, Biology and Life Sciences, Cell Biology, HLA-DR Antigens, Demyelinating Disorders, Lesions, lcsh:Q, Clinical Immunology, Clinical Medicine |
| الوصف: | Background Natalizumab (NTZ) is a drug that has been widely used in the treatment of multiple sclerosis (MS). NTZ is very effective in suppressing inflammation, but if treatment is suspended many patients will experience relapses. Objective To investigate if quantification of γδ T cells and HLA-DR+ NK cells could predict early disease reactivation after NTZ suspension. Methods Absolute counts of γδ T cells and HLA-DR+ NK cells in whole blood were determined with flow cytometry in fifteen patients treated with NTZ. NTZ treatment was then withdrawn and patients were followed with clinical visits and MR investigations. Results Patients with recurrent disease had higher absolute counts of γδ T cells 129 (+/- 156) cells/μl in comparison to patients with stable disease 50.0 (+/- 51.0) cells/mu l but the difference was not statistically significant and largely driven by outliers. Patients with recurrent and stable disease had similar absolute counts of HLA-DR+ NK cells. Conclusion Quantification of γδ T cells and HLA-DR+ NK cells could not predict active disease after NTZ suspension. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7cac57ad128534a18a3541107b0181bdTest http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-329692Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....7cac57ad128534a18a3541107b0181bd |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |