دورية أكاديمية
CD4+ T cell-induced inflammatory cell death controls immune-evasive tumours
| العنوان: | CD4+ T cell-induced inflammatory cell death controls immune-evasive tumours |
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| المؤلفون: | Kruse, Bastian, Buzzai, Anthony C., Shridhar, Naveen, Braun, Andreas D., Gellert, Susan, Knauth, Kristin, Pozniak, Joanna, Peters, Johannes, Dittmann, Paulina, Mengoni, Miriam, van der Sluis, Tetje Cornelia, Höhn, Simon, Antoranz, Asier, Krone, Anna, Fu, Yan, Yu, Di, Essand, Magnus, Geffers, Robert, Mougiakakos, Dimitrios, Kahlfuss, Sascha, Kashkar, Hamid, Gaffal, Evelyn, Bosisio, Francesca M., Bechter, Oliver, Rambow, Florian, Marine, Jean-Christophe, Kastenmüller, Wolfgang, Müller, Andreas J., Tüting, Thomas |
| بيانات النشر: | Uppsala universitet, Cancerimmunterapi Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany. VIB, Ctr Canc Biol, Lab Mol Canc Biol, Leuven, Belgium.;Katholieke Univ Leuven, Dept Oncol, Lab Mol Canc Biol, Leuven, Belgium. Katholieke Univ Leuven, Dept Imaging & Pathol, Translat Cell & Tissue Res, Leuven, Belgium. Otto von Guericke Univ, Inst Mol & Clin Immunol, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany. Helmholtz Ctr Infect Res, Braunschweig, Germany. Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.;Otto von Guericke Univ, Dept Hematol, Univ Hosp, Magdeburg, Germany. Univ Cologne, Inst Mol Immunol, Ctr Mol Med Cologne, Cologne, Germany.;Univ Cologne, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany. UZ Leuven, Dept Pathol, Leuven, Belgium. UZ Leuven, Dept Gen Med Oncol, Leuven, Belgium. Univ Hosp Essen, Inst Med IKIM, Dept Appl Computat Canc Res, Essen, Germany.;Univ Duisburg Essen, Essen, Germany. Inst Syst Immunol, Wurzburg, Germany. |
| سنة النشر: | 2023 |
| المجموعة: | Uppsala University: Publications (DiVA) |
| مصطلحات موضوعية: | Immunology in the medical area, Immunologi inom det medicinska området, Cancer and Oncology, Cancer och onkologi, Immunology, Immunologi |
| الوصف: | Most clinically applied cancer immunotherapies rely on the ability of CD8+ cytolytic T cells to directly recognize and kill tumour cells1,2,3. These strategies are limited by the emergence of major histocompatibility complex (MHC)-deficient tumour cells and the formation of an immunosuppressive tumour microenvironment4,5,6. The ability of CD4+ effector cells to contribute to antitumour immunity independently of CD8+ T cells is increasingly recognized, but strategies to unleash their full potential remain to be identified7,8,9,10. Here, we describe a mechanism whereby a small number of CD4+ T cells is sufficient to eradicate MHC-deficient tumours that escape direct CD8+ T cell targeting. The CD4+ effector T cells preferentially cluster at tumour invasive margins where they interact with MHC-II+CD11c+ antigen-presenting cells. We show that T helper type 1 cell-directed CD4+ T cells and innate immune stimulation reprogramme the tumour-associated myeloid cell network towards interferon-activated antigen-presenting and iNOS-expressing tumouricidal effector phenotypes. Together, CD4+ T cells and tumouricidal myeloid cells orchestrate the induction of remote inflammatory cell death that indirectly eradicates interferon-unresponsive and MHC-deficient tumours. These results warrant the clinical exploitation of this ability of CD4+ T cells and innate immune stimulators in a strategy to complement the direct cytolytic activity of CD8+ T cells and natural killer cells and advance cancer immunotherapies. ; Title in Web of Science: CD4(+) T cell-induced inflammatory cell death controls immune-evasive tumours |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Nature, 0028-0836, 2023, 618:7967, s. 1033-1040; orcid:0000-0002-9321-0351; orcid:0000-0001-8295-2950; orcid:0000-0001-6340-4406; orcid:0000-0003-3548-4044; orcid:0009-0002-4455-3291; orcid:0000-0002-8636-0351; orcid:0000-0002-9725-0422; orcid:0000-0001-8813-1061; orcid:0000-0002-9727-8986; http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-512802Test; PMID 37316667; ISI:001010613600011 |
| DOI: | 10.1038/s41586-023-06199-x |
| الإتاحة: | https://doi.org/10.1038/s41586-023-06199-xTest http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-512802Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.67472B9F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41586-023-06199-x |
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