دورية أكاديمية
Differential Expression of Immunogenic Proteins on Virulent Mycobacterium tuberculosis Clinical Isolates
| العنوان: | Differential Expression of Immunogenic Proteins on Virulent Mycobacterium tuberculosis Clinical Isolates |
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| المؤلفون: | Schierloh, Luis Pablo, Klepp, Laura Ines, Vazquez, Camila, Rocha, Roxana Valeria, Blanco, Federico Carlos, Balboa, Luciana, López, Beatriz, Ritacco, Gloria Viviana, Bigi, Fabiana, Sasiain, María del Carmen |
| بيانات النشر: | Hindawi Publishing Corporation |
| المجموعة: | CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) |
| مصطلحات موضوعية: | Tuberculosis, Proteomics, Serology, Immunoinformatics, https://purl.org/becyt/ford/1.6Test, https://purl.org/becyt/ford/1Test |
| الوصف: | Molecular epidemiology has revealed that Mycobacterium tuberculosis (Mtb), formerly regarded as highly conserved species, displays a considerable degree of genetic variability that can influence the outcome of the disease as well as the innate and adaptive immune response. Recent studies have demonstrated that Mtb families found worldwide today differ in pathology, transmissibility, virulence, and development of immune response. By proteomic approaches seven proteins that were differentially expressed between a local clinical isolate from Latin-American-Mediterranean (LAM) and from Haarlem (H) lineages were identified. In order to analyze the immunogenic ability, recombinant Rv2241, Rv0009, Rv0407, and Rv2624c proteins were produced for testing specific antibody responses. We found that these proteins induced humoral immune responses in patients with drug-sensitive and drug-resistant tuberculosis with substantial cross-reactivity among the four proteins. Moreover, such reactivity was also correlated with anti-Mtb-cell surface IgM, but not with anti-ManLAM, anti-PPD, or anti-Mtb-surface IgG antibodies. Therefore, the present results describe new Mtb antigens with potential application as biomarkers of TB. ; Fil: Schierloh, Luis Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina ; Fil: Klepp, Laura Ines. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina ; Fil: Vazquez, Camila. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas; Argentina ; Fil: Rocha, Roxana Valeria. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas; Argentina ; Fil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria. Centro de ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2314-6133 2314-6141 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/bmri/2014/741309Test/; http://hdl.handle.net/11336/29390Test; Schierloh, Luis Pablo; Klepp, Laura Ines; Vazquez, Camila; Rocha, Roxana Valeria; Blanco, Federico Carlos; et al.; Differential Expression of Immunogenic Proteins on Virulent Mycobacterium tuberculosis Clinical Isolates; Hindawi Publishing Corporation; BioMed Research International; 2014; 7-2014; 1-13; 741309; CONICET Digital; CONICET |
| الإتاحة: | https://doi.org/10.1155/2014/741309Test http://hdl.handle.net/11336/29390Test |
| حقوق: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by-nc-sa/2.5/arTest/ |
| رقم الانضمام: | edsbas.1FA0EBD6 |
| قاعدة البيانات: | BASE |
| تدمد: | 23146133 23146141 |
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