التفاصيل البيبلوغرافية
| العنوان: |
Effect of vitamin C on collagen structure of cardinal and uterosacral ligaments during pregnancy. |
| المؤلفون: |
Findik, R.B.1 drbedir75@yahoo.com, İlkaya, F.2, Guresci, S.3, Guzel, H.2, Karabulut, S.3, Karakaya, J.4 |
| المصدر: |
European Journal of Obstetrics & Gynecology & Reproductive Biology. Jun2016, Vol. 201, p31-35. 5p. |
| مصطلحات موضوعية: |
*VITAMIN C, *NORTHERN cardinal, *HYSTEROSCOPY, *LIGAMENTS, *PREGNANCY, *IMMUNOHISTOCHEMISTRY, *PROTEIN metabolism, *THERAPEUTIC use of vitamin C, *ANIMAL experimentation, *COLLAGEN, *DRUG design, *CLINICAL drug trials, *RATS, *METABOLISM, *ANATOMY |
| مستخلص: |
Objective: This study aimed to investigate changes in collagen structure in the cardinal and uterosacral ligaments of rats that were administered vitamin C during pregnancy.Study Design: Eighteen female rats were divided into three groups: six pregnant rats administered 1.25mg/ml/day of vitamin C during pregnancy (Group A); six non-pregnant rats that were not administered vitamin C (Group B); and six pregnant rats that were not administered vitamin C during pregnancy (Group C). Fifteen days after delivery, the uteruses of all rats were removed. The intensity of staining (mild, moderate or severe) and the extent of positive staining areas (%) of type I and type III collagen H scores for types I and III collagen, and intensity of elastin fibres in the cardinal and uterosacral ligaments were investigated immunohistochemically. Differences between groups were analysed using Kruskal-Wallis and independent samples tests.Results: The intensity and extent of type I and type III collagen, the H scores for type I and type III collagen, and the ratio of type III collagen H score: type I collagen H score differed significantly between groups. Pregnant rats administered vitamin C (Group A) had significantly higher values compared with non-pregnant rats (Group B): intensity of type I collagen (p=0.001), extent of type I collagen (p≤0.001), H score for type I collagen (p≤0.001), intensity for type III collagen (p=0.002), extent of type IV collagen (p=0.007), H score for type III collagen (p=0.017), type III collagen H score: type I collagen H score (p=0.039) and intensity of elastin fibres (p=0.097). A significant difference in the ratio of type III collagen H score: type I collagen H score was found between pregnant rats administered vitamin C (Group A) and pregnant rats not administered vitamin C (Group C) (p=0.002).Conclusions: The administration of vitamin C to rats during pregnancy had a favourable impact on collagen structure in the cardinal and uterosacral ligaments, suggesting that vitamin C supplementation during pregnancy may help to prevent pelvic organ prolapse and stress urinary incontinence. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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